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Leber Congenital Amaurosis Market Report 2025-2034: Industry Overview, Trends, And Forecast Analysis
Leber Congenital Amaurosis
What Is the Current Leber Congenital Amaurosis Market Size and Its Estimated Growth Rate?
In recent times, the market size for leber congenital amaurosis has experienced significant growth. It is anticipated to rise from $1.01 billion in 2024 to $1.07 billion in 2025, with a compound annual growth rate (CAGR) of 6.0%. The notable growth observed in the previous period is due to increased recognition of uncommon eye conditions, greater governmental funding, advancements in diagnostic methods, development of eye research institutions, and patient support campaigns.
The market size of leber congenital amaurosis is predicted to experience substantial growth in the forthcoming years, potentially increasing to $1.34 billion in 2029, with a compound annual growth rate (CAGR) of 5.9%. Factors driving growth during the forecast period include increased investments in gene therapy, rising incidences of inherited retinal diseases, regulatory green lights for new treatments, growing clinical trials, and escalation in healthcare spending. The forecast period will also see significant trends such as the introduction of CRISPR-based therapies, enhanced collaboration among biotech companies, the evolution of personalized medicine, the growth of teleophthalmology, and advancements in the technology used for retinal imaging.
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How Are Emerging Segments Shaping the Leber Congenital Amaurosis Market Landscape?
The leber congenital amaurosis market covered in this report is segmented -
1) By Treatment Type: Gene Therapy, Pharmaceutical Drugs, Retinal Prosthesis, Assistive Devices, Other Treatments
2) By Age Of Onset: Congenital Leber Congenital Amaurosis (LCA) (From Birth), Early Childhood Leber Congenital Amaurosis (LCA) (1-5 Years), Late-Onset Leber Congenital Amaurosis (LCA) (6 Years And Above)
3) By Distribution Channel:, Direct Tender, Retail Sales
4) By End User: Hospitals, Specialized Eye Clinics, Ophthalmology Research Centers, Home Care Settings, Other End Users
Subsegments:
1) By Gene Therapy: RPE65 Gene Replacement Therapy, CRISPR-Based Gene Editing, AAV (Adeno-Associated Virus) Vector Therapy, Emerging Experimental Gene Therapies
2) By Pharmaceutical Drugs: Retinoid-Based Therapies, Neuroprotective Agents, Anti-Inflammatory Drugs, Antioxidant Therapies
3) By Retinal Prosthesis: Implantable Retinal Chips, Artificial Retinal Stimulation Devices, Bionic Eye Technology
4) By Assistive Devices: Low Vision Aids, Screen Readers and Braille Devices, Mobility Aids for Vision Impairment
5) By Other Treatments: Stem Cell Therapy, Optogenetics-Based Treatments, Visual Rehabilitation Programs, Nutritional and Dietary Interventions
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Which Growth Factors Are Influencing Leber Congenital Amaurosis Market Expansion?
The escalating occurrence of genetic retinal diseases is predicted to bolster the expansion of the leber congenital amaurosis (LCA) market. Genetic retinal diseases (GRDs) are genetic abnormalities impacting the retina, which is the light-sensitive layer located at the rear of the eye and is vital for sight. The rise in genetic retinal diseases is due to the betterment in genetic testing, heightened awareness and diagnosis, and increased longevity. Technological progress in genetic testing has simplified the diagnosis process of genetic retinal diseases, resulting in the discovery of more instances. Leber congenital amaurosis enhances the comprehension of genetic retinal diseases by exposing genetic deviations and disease processes that are instrumental in devising specific therapies and treatments. For example, in January 2025, as per the UK Parliament's House of Commons Library, a government body based in the UK, about 25,000 individuals in the UK suffered from genetic retinal diseases in 2024, marking an annual increase of 2%. Consequently, the rising occurrence of genetic retinal diseases propels the leber congenital amaurosis market.
Who Are the Dominant Players Across Different Leber Congenital Amaurosis Market Segments?
Major companies operating in the leber congenital amaurosis market are Sanofi S.A., Novartis AG, Astellas Pharma Inc., Invitae Corporation, Novelion Therapeutics Inc., Andelyn Biosciences Inc., CD Genomics Inc., Editas Medicine Inc., MeiraGTx Holdings plc, Sangamo Therapeutics Inc., LKC Technologies Inc., Aldeyra Therapeutics Inc., Asper Biogene OÜ, Allergan Inc., ProQR Therapeutics N.V., GenSight Biologics S.A., Ocugen Inc., IVERIC bio Inc. (formerly Ophthotech Corporation), Atsena Therapeutics Inc., HuidaGene Therapeutics Co. Ltd.
What Are the Latest Developing Trends in the Leber Congenital Amaurosis Market?
Leading firms in the leber congenital amaurosis market, like Laboratoires Théa S.A.S. are channeling their efforts towards the invention of revolutionary solutions such as RNA-based treatments. They aim to enhance vision restoration and disease management. RNA-based treatments operate by utilizing RNA molecules to tackle diseases through gene-targeting processes. Some examples are mRNA vaccines, siRNA therapies, RNA aptamers, and antisense oligonucleotides. Laboratoires Théa S.A.S., a pharmaceutical company based in France, launched a dedicated branch known as Sepul Bio in January 2025. It's main goal is to promote the advancement of RNA therapies for inherited eye diseases, with a distinct focus on sepofarsen for leber congenital amaurosis 10 (LCA10) and ultevursen for USH2A-related retinitis pigmentosa. Sepul Bio is anticipated to make notable advancements in these uncommon genetic disorders, following the successful administration of the first dose to a patient in the LUNA Phase 2b clinical trial for ultevursen.
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Which Geographic Regions Are Expected to Dominate the Leber Congenital Amaurosis Market in the Coming Years?
North America was the largest region in the leber congenital amaurosis market in 2024. Asia-Pacific is expected to be the fastest-growing region in the forecast period. The regions covered in the leber congenital amaurosis market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East, Africa.
Frequently Asked Questions:
1. What Is the Market Size and Growth Rate of the Leber Congenital Amaurosis Market?
2. What is the CAGR expected in the Leber Congenital Amaurosis Market?
3. What Are the Key Innovations Transforming the Leber Congenital Amaurosis Industry?
4. Which Region Is Leading the Leber Congenital Amaurosis Market?
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