Cerebral Infarction Pipeline: Advancing Stroke Care with 20+ Innovators Transforming Treatment Strategies | DelveInsight

The cerebral infarction landscape is witnessing remarkable progress, fueled by groundbreaking research and innovative therapies. Leading biopharmaceutical companies such as RAstraZeneca, Athersys, NoNO, Materia Medica Holding, Dexa Medica Group, Shin Poong Pharmaceutical, and Techfields are at the forefront of developing new treatments, offering hope for more effective and tailored therapies for patients suffering from this severe neurological condition. Through their pioneering approaches, these industry leaders are transforming the treatment paradigm, introducing targeted therapies and novel interventions aimed at improving recovery, reducing mortality, and enhancing the overall quality of life for individuals affected by cerebral infarction.

DelveInsight's "Cerebral Infarction Pipeline Insight, 2025" comprehensively analyzes the current clinical landscape and growth prospects in the Cerebral Infarction market. The report covers disease insights, treatment guidelines, and a detailed pipeline assessment from preclinical to marketed stages. It includes drug mechanisms, clinical studies, regulatory progress, and key developments such as collaborations, mergers, funding, and designations.

For emerging Cerebral Infarction drugs, the Cerebral Infarction pipeline analysis report provides a 360° view of the therapeutics landscape by development point, product type, route of administration, molecule type, and MOA. The pipeline research covers business opportunities, challenges, future partnerships, strong competitors, and growth strategies.

Key Takeaways from the Cerebral Infarction Pipeline Report
• DelveInsight's Cerebral Infarction Pipeline analysis depicts a robust space with 20+ active players working to develop 20+ pipeline drugs for Cerebral Infarction treatment.
• The leading Cerebral Infarction companies include Genervon Biopharmaceuticals, Pharmazz, SanBio, Bayer, Tasly Biopharmaceuticals, AstraZeneca, Athersys, NoNO, Materia Medica Holding, Dexa Medica Group, Shin Poong Pharmaceutical, Techfields, Teijin Pharma Limited, NC Medical Research, Acticor Biotech, Meridigen Biotech, Prolong Pharmaceuticals, and others are evaluating their lead assets to improve the Cerebral Infarction treatment landscape.
• Key Cerebral Infarction pipeline therapies in various stages of development include Rozanolixizumab, Rilzabrutinib, Efgartigimod, Batoclimab, M254, Cevidoplenib, Mezagitamab, BIVV020, HMPL-523, and others.
• In March 2025, Perfuze, a leading medical device company dedicated to advancing stroke treatment, announced that it has received FDA 510(k) clearance for its ZiplineTM Access Catheters. This regulatory milestone strengthens Perfuze's growing portfolio of innovative neurovascular devices, empowering physicians to treat acute ischemic strokes with greater speed, ease, and precision. In addition, Perfuze has secured €22 million in follow-on funding.
• In March 2025, the FDA approved TNKase (tenecteplase), a thrombolytic agent, for the treatment of acute ischemic stroke in adults.
• In February 2025, Vena Medical announced that the FDA has granted Breakthrough Device designation for its MicroAngioscope, marking a "historic leap forward" in neurovascular care and stroke treatment.
• In October 2024, Prolong Pharmaceuticals, LLC, a clinical-stage biopharmaceutical company, announced that its investigational therapy, PP-007 (PEGylated carboxyhemoglobin, bovine), has been granted Fast Track designation by the FDA for treating acute ischemic stroke (AIS). PP-007 is currently undergoing safety and efficacy evaluation in the ongoing U.S.-based clinical trial, HEMERA-1.

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Cerebral Infarction Overview
A cerebral infarction, also known as an ischemic stroke, occurs when a part of the brain is deprived of adequate blood flow, leading to the death of brain tissue. This lack of blood supply-often due to atherosclerosis, which causes fatty plaque (atheroma) buildup in the blood vessels-deprives brain cells of essential oxygen and nutrients. As a result, affected brain areas begin to die. Common symptoms of a stroke include difficulty speaking, confusion or trouble understanding, muscle weakness (especially on one side of the body), severe headache, and vision disturbances.

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Cerebral Infarction Treatment Analysis: Drug Profile
PMZ-1620 (Sovateltide): Pharmazz
Sovateltide (also known as IRL-1620 or PMZ-1620) is an endothelin-B receptor agonist currently in Phase III clinical trials for the treatment of cerebral infarction (ischemic stroke). Administered intravenously, it has demonstrated the ability to enhance cerebral blood flow, prevent cell death, and promote neurovascular remodeling, showing promise as a therapeutic option for stroke recovery.

BAY 2433334: Bayer
BAY 2433334 is an oral Factor XIa inhibitor developed by Bayer, designed to interrupt the blood clotting cascade and act as a blood thinner. It is being evaluated in Phase II clinical trials for the prevention and treatment of ischemic stroke.

SP-8203: Shin Poong Pharmaceutical Co. Ltd.
SP-8203 is a novel neuroprotective agent currently in Phase II development for the treatment of acute ischemic stroke. As a quinazoline-2,4-dione derivative, it exhibits multiple neuroprotective mechanisms, including anti-inflammatory effects, aimed at minimizing brain damage and improving recovery outcomes following stroke.

Key Cerebral Infarction Therapies and Companies
• PMZ-1620: Pharamzz
• BAY 2433334: Bayer
• SP-8203: Shin Poong Pharmaceutical Co. Ltd.
• JTR-161: Teijin Pharma Limited
• Glenzocimab (ACT017): Acticor Biotech
• LT3001: Lumosa Therapeutics
• DM199: DiaMedica Therapeutics

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Cerebral Infarction Therapeutics Assessment
By Product Type
• Mono
• Combination
• Mono/Combination.

By Stage
• Late-stage products (Phase III)
• Mid-stage products (Phase II)
• Early-stage product (Phase I) along with the details of
• Pre-clinical and Discovery stage candidates
• Discontinued & Inactive candidates

By Route of Administration
• Oral
• Subcutaneous
• Intravenous
• Intramuscular

By Molecule Type
• Bispecific Antibody
• Peptides
• Small molecule
• Gene therapy

Scope of the Cerebral Infarction Pipeline Report
• Coverage: Global
• Key Cerebral Infarction Companies: Genervon Biopharmaceuticals, LLC, Pharmazz, SanBio, Inc., Bayer, Tasly Biopharmaceuticals Co., Ltd., AstraZeneca, Athersys, Inc., NoNO Inc., Materia Medica Holding, Dexa Medica Group, Shin Poong Pharmaceutical Co. Ltd., Techfields Inc, Teijin Pharma Limited, NC Medical Research, Acticor Biotech, Meridigen Biotech Co., Ltd., Prolong Pharmaceuticals, and others.
• Key Cerebral Infarction Pipeline Therapies: Rozanolixizumab, Rilzabrutinib, Efgartigimod, Batoclimab, M254, Cevidoplenib, Mezagitamab, BIVV020, HMPL-523, and others.

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Table of Contents
1. Introduction
2. Executive Summary
3. Cerebral Infarction Pipeline: Overview
4. Analytical Perspective In-depth Commercial Assessment
5. Cerebral Infarction Pipeline Therapeutics
6. Cerebral Infarction Pipeline: Late-Stage Products (Phase III)
7. Cerebral Infarction Pipeline: Late-Stage Products (Phase III)
8. Cerebral Infarction Pipeline: Mid-Stage Products (Phase II)
9. Cerebral Infarction Pipeline: Early Stage Products (Phase I)
10. Therapeutic Assessment
11. Inactive Products
12. Company-University Collaborations (Licensing/Partnering) Analysis
13. Key Companies
14. Key Products
15. Unmet Needs
16. Market Drivers and Barriers
17. Future Perspectives and Conclusion
18. Analyst Views
19. Appendix

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This release was published on openPR.