Post-Polycythemia Vera Myelofibrosis Pipeline: Revolutionizing Treatment with Over 17 Leading Innovators Shaping the Future of Medicine | DelveInsight

The Post-Polycythemia Vera Myelofibrosis (PPV-MF) landscape is undergoing significant advancements, driven by innovative research and new therapeutic strategies. Leading companies such as Parexel, Constellation Pharmaceuticals, Incyte Corporation, NS Pharma, and Celgene, are at the forefront, developing transformative treatments that aim to address unmet needs in this challenging condition. With their cutting-edge therapies, these pioneers are reshaping the treatment paradigm, offering new hope for patients living with PPV-MF. As research progresses, these advancements hold the potential to provide lasting improvements in patient outcomes and quality of life.

DelveInsight's "Post-Polycythemia Vera Myelofibrosis Pipeline Insight, 2025" comprehensively analyzes the current clinical landscape and growth prospects in the Post-Polycythemia Vera Myelofibrosis market. The report covers disease insights, treatment guidelines, and a detailed pipeline assessment from preclinical to marketed stages. It includes drug mechanisms, clinical studies, regulatory progress, and key developments such as collaborations, mergers, funding, and designations.

For emerging Post-Polycythemia Vera Myelofibrosis drugs, the Post-Polycythemia Vera Myelofibrosis pipeline analysis report provides a 360° view of the therapeutics landscape by development point, product type, route of administration, molecule type, and MOA. The pipeline research covers business opportunities, challenges, future partnerships, strong competitors, and growth strategies.

Key Takeaways from the Post-Polycythemia Vera Myelofibrosis Pipeline Report
• DelveInsight's post-polycythemia vera myelofibrosis Pipeline analysis depicts a robust space with 17+ active players working to develop 17+ pipeline drugs for post-polycythemia vera myelofibrosis treatment.
• The leading post-polycythemia vera myelofibrosis companies include Kartos Therapeutics, Inc., Parexel, Constellation Pharmaceuticals, Incyte Corporation, NS Pharma, Celgene, Lynk Pharmaceuticals Co., Ltd., Imago BioSciences, Inc., Karyopharm Therapeutics Inc., and others are evaluating their lead assets to improve the post-polycythemia vera myelofibrosis treatment landscape.
• Key post-polycythemia vera myelofibrosis pipeline therapies in various stages of development include Navtemadlin, PXS-5505, Pelabresib, Parsaclisib, NS-018, Luspatercept, LNK01002, IMG-7289, Selinexor, and others.
• In March 2025, Takeda and its partner Protagonist Therapeutics announced a Phase III success for rusfertide, which met the primary endpoint in a study involving patients with polycythemia vera (PV). The companies plan to use the results from the VERIFY trial to support marketing applications for the hepcidin mimetic peptide therapeutic.
• In December 2024, Vanda Pharmaceuticals Inc. announced that the U.S. Food and Drug Administration (FDA) granted orphan drug designation to VGT-1849A, a selective antisense oligonucleotide (ASO)-based JAK2 inhibitor, for the treatment of polycythemia vera (PV), a rare hematologic malignancy that leads to the overproduction of red blood cells by the bone marrow.

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Post-Polycythemia Vera Myelofibrosis Overview
Post-Polycythemia Vera Myelofibrosis (PPV-MF) is a rare and chronic blood cancer that can develop in patients with Polycythemia Vera, where the bone marrow becomes defective and produces abnormal blood cells, leading to the formation of scar tissue. PPV-MF is one of the most common types of intracranial tumors. In the United States, the annual incidence ranges between 98,000 to 170,000 cases. The prevalence of PPV-MF is rising due to several factors, including longer survival rates for patients with systemic metastatic disease, thanks to the introduction of new systemic therapies, such as immunotherapy. Additionally, advances in sensitive magnetic resonance imaging (MRI) techniques have enhanced the detection of small, often asymptomatic, PPV-MF cases.

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Post-Polycythemia Vera Myelofibrosis Treatment Analysis: Drug Profile
Navtemadlin: Kartos Therapeutics, Inc.
Navtemadlin (KRT-232) is an investigational cancer therapy that selectively targets and inhibits the MDM2 protein. In pre-clinical models and cell cultures, it effectively inhibited MDM2 at low concentrations and triggered dose-dependent activation of p53. This led to cell-cycle arrest through p21 activation and subsequent tumor cell death via pro-apoptotic Bcl-2 family proteins, resulting in complete and durable tumor regression. Promising clinical activity has been observed in patients with advanced cancers, including Myelofibrosis, Acute Myeloid Leukemia, and Merkel cell carcinoma. The drug is currently in Phase II/III trials for Post-Polycythemia Vera Myelofibrosis (Post-PV-MF).

Selinexor: Karyopharm Therapeutics Inc.
Selinexor is a first-in-class, oral Selective Inhibitor of Nuclear Export (SINE) compound. It works by binding to and inhibiting the nuclear export protein XPO1, which causes the accumulation of tumor suppressor proteins in the cell nucleus. This process reactivates and enhances their tumor-suppressing functions, leading to the selective induction of apoptosis in cancer cells while sparing normal cells. Selinexor is currently being evaluated in Phase II clinical trials for its efficacy and safety in patients with myelofibrosis (PMF, PET-MF, or PPV-MF) who are refractory or intolerant to JAK1/2 inhibitors.

Key Post-Polycythemia Vera Myelofibrosis Therapies and Companies
• Navtemadlin: Kartos Therapeutics, Inc.
• Selinexor: Karyopharm Therapeutics Inc.
• Pelabresib: Morphosys
• Imetelstat: Geron
• Reblozyl (Luspatercept/ACE-536): Bristol Myers Squibb
• Navtemadlin (KRT-232): Kartos Therapeutics

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Post-Polycythemia Vera Myelofibrosis Therapeutics Assessment
By Product Type
• Mono
• Combination
• Mono/Combination.

By Stage
• Late-stage products (Phase III)
• Mid-stage products (Phase II)
• Early-stage product (Phase I) along with the details of
• Pre-clinical and Discovery stage candidates
• Discontinued & Inactive candidates

By Route of Administration
• Intra-articular
• Intraocular
• Intrathecal
• Intravenous
• Ophthalmic
• Oral
• Parenteral
• Subcutaneous
• Topical
• Transdermal

By Molecule Type
• Oligonucleotide
• Peptide
• Small molecule

Scope of the Post-Polycythemia Vera Myelofibrosis Pipeline Report
• Coverage: Global
• Key Post-Polycythemia Vera Myelofibrosis Companies: Kartos Therapeutics, Inc., Parexel, Constellation Pharmaceuticals, Incyte Corporation, NS Pharma, Celgene, Lynk Pharmaceuticals Co., Ltd., Imago BioSciences, Inc., Karyopharm Therapeutics Inc., and others.
• Key Post-Polycythemia Vera Myelofibrosis Pipeline Therapies: Navtemadlin, PXS-5505, Pelabresib, Parsaclisib, NS-018, Luspatercept, LNK01002, IMG-7289, Selinexor, and others.

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Table of Contents
1. Introduction
2. Executive Summary
3. Post-Polycythemia Vera Myelofibrosis Pipeline: Overview
4. Analytical Perspective In-depth Commercial Assessment
5. Post-Polycythemia Vera Myelofibrosis Pipeline Therapeutics
6. Post-Polycythemia Vera Myelofibrosis Pipeline: Late-Stage Products (Phase III)
7. Post-Polycythemia Vera Myelofibrosis Pipeline: Late-Stage Products (Phase III)
8. Post-Polycythemia Vera Myelofibrosis Pipeline: Mid-Stage Products (Phase II)
9. Post-Polycythemia Vera Myelofibrosis Pipeline: Early Stage Products (Phase I)
10. Therapeutic Assessment
11. Inactive Products
12. Company-University Collaborations (Licensing/Partnering) Analysis
13. Key Companies
14. Key Products
15. Unmet Needs
16. Market Drivers and Barriers
17. Future Perspectives and Conclusion
18. Analyst Views
19. Appendix

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This release was published on openPR.