Global Nucleic Acid Based Gene Therapy Market to Reach $1.33 Billion by 2029, Growing at 10.7% CAGR

What Is the Expected Size and Growth Rate of the Nucleic Acid Based Gene Therapy Market?
The market size for nucleic acid-based gene therapy has seen substantial growth in the recent past. The market is projected to increase from $0.81 billion in 2024 to $0.88 billion in 2025, experiencing a compound annual growth rate (CAGR) of 9.4%. This growth during the historic period results from factors such as better comprehension of human genetics, rising demand for tailored medical treatments, an expanding pipeline of gene therapy products, increased government backing for gene therapy, and applications in genetic disorders and cancer therapy.

The market size of gene therapy based on nucleic acid is projected to experience swift growth in the coming years. It is set to expand to $1.33 billion in 2029 with a compound annual growth rate (CAGR) of 10.7%. The projected growth in this period is due to factors such as growing indications, intensified funding, heightened patient advocacy and awareness, increased investment in gene therapy research and development, broadening scope of gene therapy applications, and rare diseases. The expected trends for this period include ex vivo gene editing, advancements in in vivo gene editing, combination therapies, targeted delivery systems, gene editing for rare diseases, and non-viral vectors.

What Factors Are Fueling Growth in the Nucleic Acid Based Gene Therapy Market?
The anticipated increase in financial aid from government bodies and corporations is expected to fuel demand for nucleic acid-based gene therapy. Analogous to naturally occurring acids or proteins that govern genetic expression, nucleic acid therapeutics show promise where conventional treatments fall short, namely in providing cures for diseases like cystic fibrosis, hemophilia, sickle cell anemia, thalassemia, and diabetes. Nucleic acid medication, with its foundation in genetic profiling and molecular target identification, has the potential to transform the treatment of such illnesses by tackling their genetic roots and providing lasting cures. The rising financial support from government and corporations active in the gene therapy market is predicted to encourage demand for this type of therapeutic approach. As an example, the National Institute of Health (NIH) announced in August 2022 that they would be investing $34 million annually over the next five years to further HIV treatment research. Such government backing is expected to spur the growth of the nucleic acid-based gene therapy market.

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Which Leading Companies Are Shaping the Growth of the Nucleic Acid Based Gene Therapy Market?
Major companies operating in the nucleic acid based gene therapy market include Celsion Corporation, Wave Life Sciences, Imugene Ltd., Caperna LLC, Phylogica Limited, Protagonist Therapeutics Inc., Benitec Biopharma Ltd., EGEN, BioMedica, Transgene SA, Copernicus Therapeutics Inc., 4D Molecular Therapeutics Inc., Abeona Therapeutics Inc., Alnylam Pharmaceuticals Inc., Amgen Inc., Beam Therapeutics Inc., BioNTech SE, Bluebird Bio Inc., CRISPR Therapeutics AG, Editas Medicine Inc., Genevant Sciences Inc., Homology Medicines Inc., Intellia Therapeutics Inc., Ionis Pharmaceuticals Inc., MaxCyte Inc., Moderna Inc., Novartis International AG, Orchard Therapeutics plc, Precision BioSciences Inc., REGENXBIO Inc.

What Are the Major Trends Shaping the Nucleic Acid Based Gene Therapy Market?
In March 2023, Moderna, Inc., an American biotech firm, formed a partnership with Generation Bio. The objective of this alliance is for Moderna Inc. to foster the development of unique nucleic acid treatments, particularly those that can connect with immune cells, to expedite their individual pipelines for non-viral genetic medications and entirely finance the research and development operations related to this endeavor, with an upfront payment made for research undertakings. Generation Bio happens to be a US-based biotech firm specializing in gene therapy rooted in nucleic acid.

What Are the Key Segments of the Nucleic Acid Based Gene Therapy Market?
The nucleic acid based gene therapy market covered in this report is segmented -

1) By Technology: Anti-Sence and Anti-Gene, Short Inhibitory Sequences, Gene Transfer Therapy, Nucleoside Analogs, Ribozymes, Aptamers, Other Technologies
2) By Application: Oncology, Muscular Dystrophy/ Muscular Disorders, Rare Diseases
3) By End User: Hospitals And Clinics, Academic And Research Institutes

Subsegments:
1) By Anti-Sense And Anti-Gene: Oligonucleotide Therapeutics, Peptide Nucleic Acids (PNA), Morpholino Oligomers (MO)
2) By Short Inhibitory Sequences (siRNA): Synthetic siRNA, Encapsulation/Delivery Systems for siRNA, Target-specific siRNA Therapies
3) By Gene Transfer Therapy: Viral Vectors (Adenovirus, Lentivirus, Retrovirus, AAV), Non-Viral Vectors (Liposomes, Electroporation, Gene Gun)
4) By Nucleoside Analogs: Purine Analogs, Pyrimidine Analogs
5) By Ribozymes: Trans-Splicing Ribozymes, Hammerhead Ribozymes
6) By Aptamers: RNA Aptamers, DNA Aptamers, Small Molecule Binding Aptamers
7) By Other Technologies: CRISPR-based Gene Editing, Zinc Finger Nucleases (ZFN), Transcription Activator-Like Effector Nucleases (TALENs)

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Which Region Dominates the Nucleic Acid Based Gene Therapy Market?
North America was the largest region in the nucleic acid-based gene therapy market in 2023. Western Europe was the second-largest region in the nucleic acid-based gene therapy market report. The regions covered in the nucleic acid based gene therapy market report are Asia-Pacific, Western Europe, Eastern Europe, North America, South America, Middle East, and Africa.

What Is Covered In The Nucleic Acid Based Gene Therapy Global Market Report?

- Market Size Analysis: Analyze the Nucleic Acid Based Gene Therapy Market size by key regions, countries, product types, and applications.
- Market Segmentation Analysis: Identify various subsegments within the Nucleic Acid Based Gene Therapy Market for effective categorization.
- Key Player Focus: Focus on key players to define their market value, share, and competitive landscape.
- Growth Trends Analysis: Examine individual growth trends and prospects in the Market.
- Market Contribution: Evaluate contributions of different segments to the overall Nucleic Acid Based Gene Therapy Market growth.
- Growth Drivers: Detail key factors influencing market growth, including opportunities and drivers.
- Industry Challenges: Analyze challenges and risks affecting the Nucleic Acid Based Gene Therapy Market.
- Competitive Developments: Analyze competitive developments, such as expansions, agreements, and new product launches in the market.

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