Frontotemporal Dementia Pipeline 2025: Key Companies, MOA, ROA, and Clinical Trials Evaluation by DelveInsight by DelveInsight | Alector, Oncolys BioPharma, Denali Therapeutics Inc, Passage Bio

(Las Vegas, Nevada, United States) As per DelveInsight's assessment, globally, Frontotemporal Dementia pipeline constitutes 15+ key companies continuously working towards developing 20+ Frontotemporal Dementia treatment therapies, analysis of Clinical Trials, Therapies, Mechanism of Action, Route of Administration, and Developments analyzes DelveInsight.

"Frontotemporal Dementia Pipeline Insight, 2025 report by DelveInsight outlines comprehensive insights into the present clinical development scenario and growth prospects across the Frontotemporal Dementia Market.

The Frontotemporal Dementia Pipeline report embraces in-depth commercial and clinical assessment of the pipeline products from the pre-clinical developmental phase to the marketed phase. The report also covers a detailed description of the drug, including the mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, collaborations, mergers acquisition, funding, designations, and other product-related details.

Some of the key takeaways from the Frontotemporal Dementia Pipeline Report: https://www.delveinsight.com/sample-request/frontotemporal-dementia-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=gpr
• Companies across the globe are diligently working toward developing novel Frontotemporal Dementia treatment therapies with a considerable amount of success over the years.
• Frontotemporal Dementia companies working in the treatment market are Deep Genomics, Asceneuron SA, AviadoBio, CAMP4 Therapeutics, Neurimmune, Prevail Therapeutics, Passage Bio, Transposon Therapeutics, Alector Inc., and others, are developing therapies for the Frontotemporal Dementia treatment
• Emerging Frontotemporal Dementia therapies in the different phases of clinical trials are- Research programme CNS Therapies, Research Program M1 PAM, AVB-101, Research programme CNS, NI308, PR006, PBFT02, TPN-101, AL001, and others are expected to have a significant impact on the Frontotemporal Dementia market in the coming years.
• In January 2025, Passage Bio, Inc. (Nasdaq: PASG), a clinical-stage genetic medicines company dedicated to treating neurodegenerative diseases, has provided updated findings from its ongoing Phase 1/2 upliFT-D trial evaluating PBFT02 for frontotemporal dementia (FTD) with granulin (GRN) mutations. Additionally, the company highlighted key upcoming milestones and announced the successful completion of process development and scale-up for a suspension-based manufacturing process of PBFT02. As the program progresses, Passage Bio has reassessed its operational requirements and will shift to an outsourced analytical testing model.
• In November 2024, CervoMed Inc. (NASDAQ: CRVO), a clinical-stage company dedicated to developing therapies for age-related neurological conditions, announced that the U.S. Food and Drug Administration (FDA) has granted Orphan Drug Designation to its oral investigational treatment, neflamapimod, for frontotemporal dementia (FTD).
• In September 2024, Vesper Bio shared findings from a Phase I trial evaluating VES001, a potential disease-modifying therapy for frontotemporal dementia (FTD), specifically in patients with progranulin gene (GRN) mutations. The first participant was dosed in December last year. The study, involving 78 healthy volunteers, aimed to assess the safety, tolerability, pharmacokinetics, and pharmacodynamic target engagement of VES001.
• In April 2024, AviadoBio has announced that the initial patient has received treatment in the Phase I/II ASPIRE-FTD trial, which is assessing the company's experimental gene therapy, AVB-101, for individuals with frontotemporal dementia (FTD) caused by progranulin (GRN) gene mutations (FTD-GRN).
• In February 2024, Transposon Therapeutics has released interim findings from its Phase II trial of TPN-101, focusing on patients with amyotrophic lateral sclerosis (ALS) and/or frontotemporal dementia (FTD) associated with hexanucleotide repeat expansions in the C9orf72 gene (C9orf72-related ALS/FTD).
• In February 2024, Alector, Inc. and GSK plc have reported that the U.S. Food and Drug Administration (FDA) has awarded Breakthrough Therapy Designation to latozinemab for its potential use in treating frontotemporal dementia associated with a progranulin gene mutation (FTD-GRN).
• In December 2023, The Danish biotechnology company, Vesper Bio, has administered the initial dose to the first participant in a Phase I trial assessing the oral medication VES001 for frontotemporal dementia (FTD). This randomized, double-blind trial aims to evaluate the safety and tolerability of Vesper Bio's compound, VES001, which the company describes as a first-of-its-kind brain-penetrating medication.

Frontotemporal Dementia Overview
Frontotemporal dementia (FTD) is a collective term for a set of disorders caused by gradual loss of function in the brain's frontal and temporal lobes. These brain regions are crucial for behavior, language, and decision-making skills.

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Emerging Frontotemporal Dementia Drugs Under Different Phases of Clinical Development Include:
• Research programme CNS Therapies: Deep Genomics
• Research Program M1 PAM: Asceneuron SA
• AVB-101: AviadoBio
• Research programme CNS: CAMP4 Therapeutics
• NI308: Neurimmune
• PR006: Prevail Therapeutics
• PBFT02: Passage Bio
• TPN-101: Transposon Therapeutics
• AL001: Alector Inc.

Frontotemporal Dementia Route of Administration
Frontotemporal Dementia pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs, such as
• Intra-articular
• Intraocular
• Intrathecal
• Intravenous
• Ophthalmic
• Oral
• Parenteral
• Subcutaneous
• Topical
• Transdermal

Frontotemporal Dementia Molecule Type
Frontotemporal Dementia Products have been categorized under various Molecule types, such as
• Oligonucleotide
• Peptide
• Small molecule

Frontotemporal Dementia Pipeline Therapeutics Assessment
• Frontotemporal Dementia Assessment by Product Type
• Frontotemporal Dementia By Stage and Product Type
• Frontotemporal Dementia Assessment by Route of Administration
• Frontotemporal Dementia By Stage and Route of Administration
• Frontotemporal Dementia Assessment by Molecule Type
• Frontotemporal Dementia by Stage and Molecule Type

DelveInsight's Frontotemporal Dementia Report covers around 20+ products under different phases of clinical development like
• Late-stage products (Phase III)
• Mid-stage products (Phase II)
• Early-stage product (Phase I)
• Pre-clinical and Discovery stage candidates
• Discontinued & Inactive candidates
• Route of Administration

Further Frontotemporal Dementia product details are provided in the report. Download the Frontotemporal Dementia pipeline report to learn more about the emerging Frontotemporal Dementia therapies
https://www.delveinsight.com/sample-request/frontotemporal-dementia-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=gpr

Some of the key companies in the Frontotemporal Dementia Therapeutics Market include:
Key companies developing therapies for Frontotemporal Dementia are - Alector Inc., Transposon Therapeutics, Oncolys BioPharma, Denali Therapeutics Inc, Passage Bio, Inc., Prevail Therapeutics, Wave Life Sciences, and others.

Frontotemporal Dementia Pipeline Analysis:
The Frontotemporal Dementia pipeline report provides insights into
• The report provides detailed insights about companies that are developing therapies for the treatment of Frontotemporal Dementia with aggregate therapies developed by each company for the same.
• It accesses the Different therapeutic candidates segmented into early-stage, mid-stage, and late-stage of development for Frontotemporal Dementia Treatment.
• Frontotemporal Dementia key companies are involved in targeted therapeutics development with respective active and inactive (dormant or discontinued) projects.
• Frontotemporal Dementia Drugs under development based on the stage of development, route of administration, target receptor, monotherapy or combination therapy, a different mechanism of action, and molecular type.
• Detailed analysis of collaborations (company-company collaborations and company-academia collaborations), licensing agreement and financing details for future advancement of the Frontotemporal Dementia market.
The report is built using data and information traced from the researcher's proprietary databases, company/university websites, clinical trial registries, conferences, SEC filings, investor presentations, and featured press releases from company/university websites and industry-specific third-party sources, etc.

Download Sample PDF Report to know more about Frontotemporal Dementia drugs and therapies
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Frontotemporal Dementia Pipeline Market Drivers
• Increasing prevalence of geriatric population, increasing drug development grants, increasing collaborations among companies are some of the important factors that are fueling the Frontotemporal Dementia Market.

Frontotemporal Dementia Pipeline Market Barriers
• However, lack of proper diagnosis, higher chances of misunderstanding with Alzheimer's disease and other factors are creating obstacles in the Frontotemporal Dementia Market growth.

Scope of Frontotemporal Dementia Pipeline Drug Insight
• Coverage: Global
• Key Frontotemporal Dementia Companies: Deep Genomics, Asceneuron SA, AviadoBio, CAMP4 Therapeutics, Neurimmune, Prevail Therapeutics, Passage Bio, Transposon Therapeutics, Alector Inc., and others
• Key Frontotemporal Dementia Therapies: Research programme CNS Therapies, Research Program M1 PAM, AVB-101, Research programme CNS, NI308, PR006, PBFT02, TPN-101, AL001, and others
• Frontotemporal Dementia Therapeutic Assessment: Frontotemporal Dementia current marketed and Frontotemporal Dementia emerging therapies
• Frontotemporal Dementia Market Dynamics: Frontotemporal Dementia market drivers and Frontotemporal Dementia market barriers

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Table of Contents
1. Frontotemporal Dementia Report Introduction
2. Frontotemporal Dementia Executive Summary
3. Frontotemporal Dementia Overview
4. Frontotemporal Dementia- Analytical Perspective In-depth Commercial Assessment
5. Frontotemporal Dementia Pipeline Therapeutics
6. Frontotemporal Dementia Late Stage Products (Phase II/III)
7. Frontotemporal Dementia Mid Stage Products (Phase II)
8. Frontotemporal Dementia Early Stage Products (Phase I)
9. Frontotemporal Dementia Preclinical Stage Products
10. Frontotemporal Dementia Therapeutics Assessment
11. Frontotemporal Dementia Inactive Products
12. Company-University Collaborations (Licensing/Partnering) Analysis
13. Frontotemporal Dementia Key Companies
14. Frontotemporal Dementia Key Products
15. Frontotemporal Dementia Unmet Needs
16 . Frontotemporal Dementia Market Drivers and Barriers
17. Frontotemporal Dementia Future Perspectives and Conclusion
18. Frontotemporal Dementia Analyst Views
19. Appendix
20. About DelveInsight

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