ANGPTL3 Inhibitor Market Poised for Significant Growth with Emerging Therapies, estimates DelveInsight

(Albany, USA) DelveInsight's ANGPTL3 Inhibitor Market Insights report provides an in-depth analysis of treatment practices, emerging ANGPTL3 inhibitors, market share of individual therapies, and the current and forecasted ANGPTL3 inhibitor market size from 2021 to 2034 across the 7MM [the United States, the EU-4 (Germany, France, Italy, and Spain), the United Kingdom, and Japan].

The ANGPTL3 inhibitor market is expected to witness substantial growth in the coming years, driven by increasing research in cardiovascular diseases and lipid metabolism disorders. As the understanding of ANGPTL3's role in lipid regulation advances, pharmaceutical companies are investing in novel inhibitors to address unmet medical needs in conditions such as homozygous familial hypercholesterolemia (HoFH), mixed dyslipidemia, atherosclerotic cardiovascular disease (ASCVD), and severe hypertriglyceridemia.

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Key Takeaways from the ANGPTL3 Inhibitor Market Report
• The ANGPTL3 inhibitor market is anticipated to grow at a significant CAGR by 2034, driven by advancements in lipid-lowering therapies and an increasing prevalence of cardiovascular diseases.
• Regeneron Pharmaceuticals' EVKEEZA (Evinacumab) remains the only FDA-approved ANGPTL3 inhibitor for treating HoFH since 2021.
• Emerging therapies from leading companies, including Arrowhead Pharmaceuticals, Verve Therapeutics, Eli Lilly, and others, are expected to reshape the ANGPTL3 inhibitor market landscape.
• Zodasiran (ARO-ANG3) by Arrowhead Pharmaceuticals is progressing towards Phase III trials for HoFH in 2025, following promising clinical data supporting its use.
• VERV-201 by Verve Therapeutics, designed for refractory hypercholesterolemia and HoFH, is anticipated to provide key program updates in the second half of 2025.
• In February 2025, Arrowhead Pharmaceuticals announced in conference call that company is planning to begin a Phase III study in HoFH next quarter with zodasiran.
• In May 2024, Arrowhead Pharmaceuticals announced the results of the Phase IIb ARCHES-2 study of zodasiran in patients with mixed hyperlipidemia. Zodasiran was associated with robust and durable reductions in triglycerides, triglyceride-rich lipoprotein remnants, and total atherogenic lipoproteins, including LDL-C.
• A November 2024 PubMed review explored inhibiting the ANGPTL3/8 complex for preventing atherosclerotic cardiovascular disease, suggesting potential cardiovascular benefits beyond lipid lowering, such as improving vascular inflammation, though further research is needed.
• In November 2024, Verve Therapeutics announced that the first participant was dosed with VERVE-201 in its Pulse-1 open-label Phase Ib clinical trial. The Pulse-1 clinical trial is designed to evaluate the safety and tolerability of VERVE-201 administration in adult patients with refractory hypercholesterolemia who require additional lowering of LDL-C despite treatment with maximally tolerated standard of care therapies, potentially including PCSK9 inhibitors.

Discover the latest advancements and key players shaping the ANGPTL3 inhibitor market @ ANGPTL3 Inhibitor Market Report - https://www.delveinsight.com/report-store/angptl3-inhibitor-market-forecast?utm_source=openpr&utm_medium=pressrelease&utm_campaign=apr

ANGPTL3 Inhibitor Overview
ANGPTL3 (angiopoietin-like protein 3) plays a crucial role in lipid metabolism by inhibiting lipoprotein lipase (LPL) and endothelial lipase (EL), leading to increased LDL-C and triglyceride levels. Genetic studies have shown that loss-of-function mutations in ANGPTL3 are associated with lower LDL-C, lower triglycerides, and a reduced risk of cardiovascular disease.
By mimicking these genetic mutations, ANGPTL3 inhibitors offer an innovative approach to treating severe hypertriglyceridemia, mixed dyslipidemia, and HoFH, particularly in patients who do not respond adequately to statins, PCSK9 inhibitors, or conventional lipid-lowering therapies.

Key Emerging ANGPTL3 Inhibitors and Companies
Several pharmaceutical companies are actively developing ANGPTL3 inhibitors to address lipid disorders and cardiovascular diseases. Some of the key emerging therapies in this space include:
• Vupanorsen (Pfizer & Ionis Pharmaceuticals) - A second-generation antisense oligonucleotide targeting ANGPTL3 to reduce triglyceride and LDL-C levels in patients with dyslipidemia.
• ARO-ANG3 (Arrowhead Pharmaceuticals) - A promising RNA interference (RNAi) therapy designed to inhibit ANGPTL3 and improve lipid metabolism in hyperlipidemia and metabolic disorders.
• MK-0616 (Merck & Co.) - An oral PCSK9 inhibitor in development that may work synergistically with ANGPTL3 inhibitors for broader lipid-lowering effects.
• Lomitapide (Amryt Pharma) - Though primarily an MTP inhibitor, it has implications in lipid metabolism alongside emerging ANGPTL3-targeted therapies.
With ongoing clinical trials and increasing investment in lipid-targeting drugs, ANGPTL3 inhibitors hold significant potential in reshaping cardiovascular disease management.

ANGPTL3 Inhibitor Market Dynamics
The ANGPTL3 inhibitor market is influenced by factors such as scientific advancements, competitive pharmaceutical developments, and evolving regulatory landscapes. The growing demand for targeted lipid-lowering therapies has driven increased investment in ANGPTL3 inhibitors, which work by reducing triglycerides, LDL cholesterol (LDL-C), and other atherogenic lipoproteins.

Pharmaceutical companies are actively exploring RNA-based therapies, monoclonal antibodies, and small molecules as innovative approaches to ANGPTL3 inhibition. Unlike Antisense Oligonucleotide (ASO) therapy, siRNA-based approaches like Zodasiran enable prolonged ANGPTL3 inhibition with less frequent dosing, making them a promising alternative for long-term lipid management.
However, challenges such as high treatment costs and long-term safety concerns pose potential barriers to market expansion. EVKEEZA, for instance, has an annual cost of approximately USD 450,000, limiting its accessibility and widespread adoption. Nevertheless, the anticipated approval of novel ANGPTL3 inhibitors is expected to drive competition and potentially reduce therapy costs in the future.

Key Emerging ANGPTL3 Inhibitors and Companies
• Zodasiran (ARO-ANG3) - Arrowhead Pharmaceuticals
• VERV-201 - Verve Therapeutics
• Solbinsiran - Eli Lilly and Company
• ALN-ANG3 - Alnylam Pharmaceuticals
These emerging therapies are poised to transform lipid disorder management and unlock new opportunities for medical innovation and economic growth.

To stay updated on the latest ANGPTL3 inhibitor clinical trials and approvals, visit @ ANGPTL3 Inhibitor Clinical Trials - https://www.delveinsight.com/report-store/angptl3-inhibitor-market-forecast?utm_source=openpr&utm_medium=pressrelease&utm_campaign=apr

ANGPTL3 Inhibitor Epidemiology Segmentation
The ANGPTL3 inhibitor market report provides a detailed epidemiological analysis of historical, current, and forecasted patient populations across the 7MM, segmented into:
• Total Prevalent Cases of Selected Indications (HoFH, mixed dyslipidemia, severe hypertriglyceridemia, ASCVD, and others)
• Total Eligible Patient Pool for ANGPTL3 Inhibitors in Selected Indications
• Total Treated Cases for ANGPTL3 Inhibitors

Download the report to understand how epidemiologists project the ANGPTL3 inhibitor patient trends in the 7MM @ ANGPTL3 Inhibitor Epidemiological Insight - https://www.delveinsight.com/sample-request/angptl3-inhibitor-market-forecast?utm_source=openpr&utm_medium=pressrelease&utm_campaign=apr

The ANGPTL3 inhibitor market represents a promising and evolving segment of the cardiovascular therapeutics landscape. As new therapies move through clinical trials and gain regulatory approvals, the market is expected to expand, offering more effective treatment options for lipid metabolism disorders.
Pharmaceutical innovation, competitive market dynamics, and favorable regulatory support will be key drivers of growth in the coming years, shaping the trajectory of ANGPTL3 inhibitors and their role in cardiovascular disease management.

For more insights into the future of the ANGPTL3 inhibitor market, request the full report @ ANGPTL3 Inhibitor Market Forecast 2034 - https://www.delveinsight.com/sample-request/angptl3-inhibitor-market-forecast?utm_source=openpr&utm_medium=pressrelease&utm_campaign=apr

Table of Contents:
1. Key Insights
2. Report Introduction
3. Executive Summary of ANGPTL3 Inhibitor
4. Key Events
5. Epidemiology Market Forecast Methodology
6. ANGPTL3 Inhibitor Market Overview at a Glance in the 7MM
7. ANGPTL3 Inhibitor: Background and Overview
7.1. Introduction
7.2. Potential of ANGPTL3 Inhibitor in Different Indications
7.3. Clinical Applications of ANGPTL3 Inhibitor
8. ANGPTL3 Inhibitor Target Patient Pool
8.1. Assumptions and Rationale
8.2. Key Findings
8.2. Total Cases of Selected Indication for ANGPTL3 Inhibitor in the 7MM
8.3. Total Eligible Patient Pool of Selected Indication for ANGPTL3 Inhibitor in the 7MM
8.4. Total Treatable Cases of Selected Indication for ANGPTL3 Inhibitor in the 7MM
9. Marketed ANGPTL3 Inhibitor Therapies
10. Emerging ANGPTL3 Inhibitor Therapies
11. ANGPTL3 Inhibitor: Seven Major Market Analysis
12. ANGPTL3 Inhibitor SWOT Analysis
13. ANGPTL3 Inhibitor KOL Views
14. ANGPTL3 Inhibitor Unmet Needs
15. ANGPTL3 Inhibitor Market Access and Reimbursement
16. Appendix
16.1. Bibliography
16.2. Report Methodology
17. DelveInsight Capabilities
18. Disclaimer
19. About DelveInsight

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