Press release
Knee Osteoarthritis Pipeline: Over 50 Innovators Pioneering Breakthrough Therapies | DelveInsight
Knee Osteoarthritis Pipeline
DelveInsight's "Knee Osteoarthritis Pipeline Insight, 2025" comprehensively analyzes the current clinical landscape and growth prospects in the Knee Osteoarthritis market. The report covers disease insights, treatment guidelines, and a detailed pipeline assessment from preclinical to marketed stages. It includes drug mechanisms, clinical studies, regulatory progress, and key developments such as collaborations, mergers, funding, and designations.
For emerging Knee Osteoarthritis drugs, the Knee Osteoarthritis pipeline analysis report provides a 360° view of the therapeutics landscape by development point, product type, route of administration, molecule type, and MOA. The pipeline research covers business opportunities, challenges, future partnerships, strong competitors, and growth strategies.
Key Takeaways from the Knee Osteoarthritis Pipeline Report
• DelveInsight's Knee Osteoarthritis Pipeline analysis depicts a robust space with 50+ active players working to develop 60+ pipeline drugs for Knee Osteoarthritis treatment.
• The leading Knee Osteoarthritis companies include Bone Therapeutics, Moebius Medical, UnicoCell Biomed CO. LTD, Gwo Xi Stem Cell Applied Technology, Bioventus LLC, CAR-T (Shanghai) Biotechnology, Novartis, Personalized Stem Cells, Centrexion Therapeutics, Akan Biosciences, Samumed LLC, Purdue Pharma, Anika Therapeutics, Peptinov SAS, Flexion Therapeutics, Centrexion Therapeutics, Taiwan Liposome Company, Techfields Pharma, AstraZeneca, Ampio Pharmaceuticals, BioIntegrate, Sorrento Therapeutics, Swiss Medica XXI Century S.A., OrthoTrophix, R-Bio, Amzell, Eupraxia Pharmaceuticals, Meluha Life Sciences SDN BHD, Vivex Biomedical, Orient Europharma Co., Ltd., Paradigm Biopharmaceuticals, Abbvie, Galapagos NV, Regeneron Pharmaceuticals, Xalud Therapeutics, Yooyoung Pharmaceutical, Eupraxia Pharmaceuticals, Celltex Therapeutics Corporation, Eli Lilly and Company, Sclnow Biotechnology, Mestex AG, Mitsubishi Tanabe Pharma Corporation, Propella Therapeutics, PT. Prodia Stem Cell Indonesia, and others are evaluating their lead assets to improve the Knee Osteoarthritis treatment landscape.
• Key Knee Osteoarthritis pipeline therapies in various stages of development include Lorecivivint, EP-104IAR, LG00034053, JTA-004, X 0002, TTAX03, OLP 1002, PPV 06, Canakinumab, Elixcyte, GXCPC1, LNA043, CNTX-4975-05, Autologous adipose derived stromal vascular fraction therapeutic, Cingal, TLC599, and others.
• In February 2025, Aurora Pharmaceutical announced the availability of EquiCoxib, the FDA-approved generic equivalent of EQUIOXX (firocoxib), a non-steroidal anti-inflammatory drug (NSAID) used to treat pain and inflammation associated with osteoarthritis.
• In February 2025, Zydus Lifesciences announced that it has received final approval from the USFDA to manufacture Ibuprofen and Famotidine tablets (800 mg/26.6 mg), branded as Duexis. This combination is used to relieve symptoms of rheumatoid arthritis and osteoarthritis and reduce the risk of upper gastrointestinal ulcers in patients using ibuprofen for these conditions.
• In November 2024, the US FDA completed a 30-day review of Paradigm Biopharmaceuticals' phase III pivotal clinical trial protocol for repurposed pentosan polysulfate sodium (ZILOSUL) to treat knee osteoarthritis (OA), clearing the way for the trial to begin in Q1 CY25.
Request a sample and discover the recent breakthroughs happening in the Knee Osteoarthritis pipeline landscape @ https://www.delveinsight.com/report-store/knee-osteoarthritis-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=jpr
Knee Osteoarthritis Overview
Osteoarthritis (OA) is the most common form of arthritis, often referred to as degenerative joint disease or "wear and tear" arthritis. It primarily affects the hands, hips, and knees, leading to cartilage breakdown and bone changes over time. This progressive condition causes pain, stiffness, swelling, and in severe cases, reduced mobility and disability. The knee joint, which connects the femur, tibia, fibula, and patella, relies on smooth cartilage for frictionless movement. When cartilage deteriorates, it cannot regenerate effectively, making OA a lasting and debilitating condition.
Find out more about Knee Osteoarthritis medication @ https://www.delveinsight.com/report-store/knee-osteoarthritis-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=jpr
Knee Osteoarthritis Treatment Analysis: Drug Profile
Lorecivivint: Biosplice Therapeutics
Lorecivivint (SM04690) is a small-molecule CLK/DYRK1A inhibitor targeting Wnt and inflammatory pathways. Preclinical studies suggest it has a dual mechanism of action-reducing inflammation, slowing cartilage degradation, and promoting cartilage generation. Currently, Lorecivivint is in Phase III clinical trials for knee osteoarthritis.
EP-104IAR: Eupraxia Pharmaceuticals Inc.
EP-104IAR is a long-acting corticosteroid therapy designed to provide extended pain relief for knee OA while minimizing systemic side effects. It encapsulates fluticasone propionate within a thin polymer membrane, allowing slow diffusion into the knee joint for up to six months. This approach aims to deliver sustained pain relief with an improved safety profile. Currently, EP-104IAR is in Phase II clinical trials for knee osteoarthritis.
Key Knee Osteoarthritis Therapies and Companies
• Lorecivivint: Biosplice Therapeutics
• EP-104IAR: Eupraxia Pharmaceuticals Inc
• LG00034053: LG Chem
• TLC599: Taiwan Liposome Company
• CNTX-4975: Centrexion Therapeutics
• HP-5000: Noven Pharmaceuticals
• Invossa (TG-C): Kolon TissueGene
Learn more about the novel and emerging Knee Osteoarthritis pipeline therapies @ https://www.delveinsight.com/report-store/knee-osteoarthritis-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=jpr
Knee Osteoarthritis Therapeutics Assessment
By Product Type
• Mono
• Combination
• Mono/Combination.
By Stage
• Late-stage products (Phase III)
• Mid-stage products (Phase II)
• Early-stage product (Phase I) along with the details of
• Pre-clinical and Discovery stage candidates
• Discontinued & Inactive candidates
By Route of Administration
• Oral
• Intravenous
• Subcutaneous
• Parenteral
• Topical
By Molecule Type
• Recombinant fusion proteins
• Small molecule
• Monoclonal antibody
• Peptide
• Polymer
• Gene therapy
Scope of the Knee Osteoarthritis Pipeline Report
• Coverage: Global
• Key Knee Osteoarthritis Companies: Bone Therapeutics, Moebius Medical, UnicoCell Biomed CO. LTD, Gwo Xi Stem Cell Applied Technology, Bioventus LLC, CAR-T (Shanghai) Biotechnology, Novartis, Personalized Stem Cells, Centrexion Therapeutics, Akan Biosciences, Samumed LLC, Purdue Pharma, Anika Therapeutics, Peptinov SAS, Flexion Therapeutics, Centrexion Therapeutics, Taiwan Liposome Company, Techfields Pharma, AstraZeneca, Ampio Pharmaceuticals, BioIntegrate, Sorrento Therapeutics, Swiss Medica XXI Century S.A., OrthoTrophix, R-Bio, Amzell, Eupraxia Pharmaceuticals, Meluha Life Sciences SDN BHD, Vivex Biomedical, Orient Europharma Co., Ltd., Paradigm Biopharmaceuticals, Abbvie, Galapagos NV, Regeneron Pharmaceuticals, Xalud Therapeutics, Yooyoung Pharmaceutical, Eupraxia Pharmaceuticals, Celltex Therapeutics Corporation, Eli Lilly and Company, Sclnow Biotechnology, Mestex AG, Mitsubishi Tanabe Pharma Corporation, Propella Therapeutics, PT. Prodia Stem Cell Indonesia, and others.
• Key Knee Osteoarthritis Pipeline Therapies: Lorecivivint, EP-104IAR, LG00034053, JTA-004, X 0002, TTAX03, OLP 1002, PPV 06, Canakinumab, Elixcyte, GXCPC1, LNA043, CNTX-4975-05, Autologous adipose derived stromal vascular fraction therapeutic, Cingal, TLC599, and others.
Dive deep into rich insights for drugs used for Knee Osteoarthritis treatment; visit @ https://www.delveinsight.com/report-store/knee-osteoarthritis-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=jpr
Table of Contents
1. Introduction
2. Executive Summary
3. Knee Osteoarthritis Pipeline: Overview
4. Analytical Perspective In-depth Commercial Assessment
5. Knee Osteoarthritis Pipeline Therapeutics
6. Knee Osteoarthritis Pipeline: Late-Stage Products (Phase III)
7. Knee Osteoarthritis Pipeline: Late-Stage Products (Phase III)
8. Knee Osteoarthritis Pipeline: Mid-Stage Products (Phase II)
9. Knee Osteoarthritis Pipeline: Early Stage Products (Phase I)
10. Therapeutic Assessment
11. Inactive Products
12. Company-University Collaborations (Licensing/Partnering) Analysis
13. Key Companies
14. Key Products
15. Unmet Needs
16. Market Drivers and Barriers
17. Future Perspectives and Conclusion
18. Analyst Views
19. Appendix
Contact Us:
Jatin Vimal
jvimal@delveinsight.com
+14699457679
Healthcare Consulting
https://www.delveinsight.com/consulting-services
About DelveInsight
DelveInsight is a leading Business Consultant and Market Research firm focused exclusively on life sciences. It supports Pharma companies by providing comprehensive end-to-end solutions to improve their performance. Get hassle-free access to all the healthcare and pharma market research reports through our subscription-based platform PharmDelve.
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