The Global Oral Vaccines Market Poised for Strong Growth, Projected to Reach USD 8.8 Billion by 2033

The global oral vaccines market is set to experience substantial growth, with revenue expected to increase from USD 3,985.9 million in 2024 to USD 8,800 million by 2033, reflecting a robust compound annual growth rate (CAGR) of 9.2% during the forecast period. This expansion is largely attributed to routine immunization programs, efforts to strengthen healthcare systems, and the rising demand for vaccines that are safer, more convenient, and cost-effective compared to injectable alternatives.

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Growing Importance of Routine Immunization

Routine immunization has become a key focus for governments worldwide, ensuring protection against chronic illnesses while preventing disease transmission within communities. The World Health Organization (WHO) has emphasized the importance of regular immunization programs, with all countries in the WHO South-East Asia region actively prioritizing them. A notable example is the Pan American Health Organization (PAHO), which in November 2020, reaffirmed Brazil's measles, rubella, and congenital rubella syndrome (CRS)-free status, highlighting the success of vaccination campaigns in disease eradication.

Rising Prevalence of Infectious Diseases Driving Market Growth

The increasing prevalence of infectious diseases, such as cholera and tuberculosis, is expected to drive demand for oral vaccines. WHO data from 2019 highlights millions of reported cases of these diseases worldwide, reinforcing the need for effective vaccination strategies. Government initiatives supporting vaccine approvals are also playing a crucial role. For instance, the U.S. FDA's 2016 approval of Vaxchora, the first oral cholera vaccine in the country, reflects the commitment of regulatory bodies to expanding vaccine accessibility for high-risk populations.

Another significant development is the WHO prequalification of oral rotavirus vaccines such as Rotavac and Rotasiil, which has enabled their widespread adoption in national immunization programs across low- and middle-income countries. Government partnerships with global health organizations, such as Gavi, the Vaccine Alliance, have further facilitated vaccine funding and distribution, strengthening the market's growth trajectory.

Market Dynamics

Driver: Rising Incidence of Infectious Diseases

The increasing frequency of infectious disease outbreaks, such as cholera and typhoid, is a major driver of the oral vaccines market. Cholera remains a significant public health challenge, with WHO reporting 535,321 cases and 4,007 deaths in 2023 across 45 countries. Similarly, typhoid fever continues to affect around 9 million individuals annually, leading to approximately 110,000 deaths. The WHO now recommends typhoid conjugate vaccines for children as young as six months and adults up to 65 years, further expanding the potential market for oral vaccines.

Oral vaccines are particularly valuable in low- and middle-income countries where healthcare access and sanitation infrastructure are limited. Their ease of administration and non-invasive delivery make them ideal for large-scale immunization programs. For instance, oral cholera vaccines have played a vital role in outbreak control, especially in regions affected by natural disasters or armed conflicts. Similarly, oral rotavirus vaccines have significantly reduced hospitalizations and child mortality due to diarrhea, particularly in high-burden countries. Increasing awareness and adoption of these vaccines, alongside continued technological advancements in vaccine formulation and stability, will further propel market growth.

Restraint: Challenges in Oral Vaccine Stability in Gastrointestinal Environments

A key challenge limiting the market's expansion is the need for oral vaccines to withstand the harsh conditions of the gastrointestinal tract. The stomach's acidic environment, varying pH levels, and digestive enzymes can degrade vaccine potency, reducing efficacy. Unlike injectable vaccines, which benefit from numerous immune adjuvants, oral vaccines face limitations in immune enhancement. In response, researchers are actively developing innovative mucosal adjuvants and delivery technologies to improve stability and immunogenicity in the digestive system. These advancements will be crucial in overcoming existing barriers and optimizing oral vaccine performance.

Trend: Increasing Government Support for New Product Approvals

Government support is a critical factor driving innovation and market expansion in oral vaccines. Regulatory agencies worldwide are prioritizing the approval and development of new oral vaccines to address urgent public health challenges. A notable example is Vaxart, which received a $453 million funding award from the Biomedical Advanced Research and Development Authority (BARDA) in 2024 to conduct a Phase 2b study comparing its oral COVID-19 vaccine with an FDA-approved mRNA vaccine. This large-scale trial, expected to enroll 10,000 subjects, will evaluate both symptomatic and asymptomatic disease prevention, immune response, and safety outcomes.

The WHO has also played a pivotal role in accelerating the prequalification process for oral cholera vaccines, such as Dukoral and Shanchol, to combat outbreaks in regions like sub-Saharan Africa and Southeast Asia. These approvals have improved vaccine accessibility and demonstrated the effectiveness of global health organization interventions in addressing critical infectious diseases.

Additionally, oral vaccines are preferred for mass immunization campaigns due to their ease of administration, prompting governments to fund immunization initiatives in resource-limited settings. India's strong support for ROTAVAC, a domestically produced oral rotavirus vaccine, has significantly reduced child mortality rates linked to rotavirus diarrhea. Similar initiatives, such as the Coalition for Epidemic Preparedness Innovations (CEPI), funded by multiple governments, are fostering research on oral vaccines for emerging infectious diseases like Lassa fever and Nipah virus. These efforts not only accelerate vaccine development but also encourage private-sector investment in oral vaccine innovation.

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Key Players in Oral Vaccines Market

Sanofi
GSK
Takeda Pharmaceuticals
Soligenix
Liquidia Technologies
Elasmogen
Abivax
Oravax Medical
Rapid Dose Therapeutics
AVRO Life Science
Prokarium Ltd
Matinas Biopharma
ACM Biolabs
Alcami
Other Prominent Players

Segments Covered in The Report
By Vaccine Type
Live Attenuated
Inactive
Recombinant
Subunit
Others

By Application
Polio
Tuberculosis
Rabies
Influenza
Cholera
Cancer
COVID 19
Others

By Target Population
Paediatric Population (Children)
Adults
Geriatric Population

By End Users
Hospitals & Vaccination Centres
Home Care Settings
Others

By Distribution Channel
Hospital Pharmacies
Retail Pharmacies
Online Pharmacies

By Geography
North America
The USA
Canada
Mexico
Europe
Western Europe
The UK
Germany
France
Italy
Spain
Rest of Western Europe
Eastern Europe
Poland
Russia
Rest of Eastern Europe
Asia Pacific
China
India
Japan
Australia & New Zealand
South Korea
ASEAN
Rest of Asia Pacific
Middle East & Africa
Saudi Arabia
South Africa
UAE
Rest of MEA
South America
Argentina
Brazil
Rest of South America

Conclusion
The global oral vaccines market is set for substantial expansion, driven by increasing infectious disease prevalence, strong government support, and growing adoption of non-invasive immunization solutions. As technological advancements improve vaccine stability and efficacy, and as governments continue to prioritize vaccine development, oral vaccines will play an increasingly vital role in global health. With ongoing research and strategic collaborations, the market is poised to achieve significant milestones in improving immunization coverage and disease prevention worldwide.

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This release was published on openPR.