Osteoarthritis Clinical and Non-Clinical Studies, Key Companies, Therapeutic Assessment, Emerging Therapies, Treatment Algorithm, and Pipeline Analysis | Biosplice Therapeutics, Cynata Therapeutics, Bone Therapeutics S.A, Regeneron Pharmaceuticals, Techfi

Osteoarthritis Pipeline constitutes 100+ key companies continuously working towards developing 110+ Osteoarthritis treatment therapies, analyzes DelveInsight.

Osteoarthritis Overview:

Osteoarthritis (OA) is the most prevalent type of arthritis, often referred to as degenerative joint disease or "wear and tear" arthritis. It commonly affects the hands, hips, and knees. OA occurs when the cartilage in a joint starts to deteriorate, leading to changes in the underlying bone. These changes tend to develop gradually and worsen over time. OA can result in pain, stiffness, and swelling. In more severe cases, it can impair function and cause disability, making it difficult for individuals to perform daily activities or work. Symptoms typically include joint pain that worsens with activity but improves with rest, stiffness that lasts for less than 30 minutes after periods of inactivity, and a feeling of instability in the joint. Affected joints may also produce a grinding or creaking noise during movement, and swelling can occur, particularly after extended use.

The development of osteoarthritis (OA) is a complex process that affects the entire joint, involving various tissues such as articular cartilage, subchondral bone, synovium, and ligaments. While OA was once thought to be primarily a cartilage disease, recent studies show that it is driven by a combination of factors, including mechanical stress, inflammation, and biochemical changes. Key factors in the progression of OA include the activation of pro-inflammatory cytokines, such as interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-α), which contribute to cartilage breakdown and inflammation of the synovium. Additionally, changes in the extracellular matrix, increased production of matrix metalloproteinases (MMPs), and alterations in subchondral bone remodeling are essential in the disease's progression. This comprehensive understanding emphasizes the importance of developing treatments that address the multifactorial nature of OA, moving beyond traditional methods that focus solely on cartilage damage.

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"Osteoarthritis Pipeline Insight 2024" report by DelveInsight provides a comprehensive analysis of the ongoing clinical development activities and growth prospects across the Osteoarthritis Therapeutics Market.

Key Takeaways from the Osteoarthritis Pipeline Report

DelveInsight's Osteoarthritis pipeline report depicts a robust space with 100+ active players working to develop 110+ pipeline therapies for Osteoarthritis treatment.
In February 2025, Medipost Co. Ltd. is conducting a clinical trial for patients diagnosed with Kellgren-Lawrence (K&L) Grade 2 or 3 knee osteoarthritis, based on radiographic examination. Only participants who voluntarily consent by completing the Informed Consent document will undergo screening to determine eligibility. During screening, the severity of OA in each knee will be assessed, and the more severely affected knee (index knee) will be selected for treatment, allowing enrollment in the study.
In January 2025, Novartis Pharmaceuticals launched a study to evaluate the articular cartilage-regenerating potential of RHH646 in the knee, along with its safety and tolerability in participants with knee osteoarthritis. The treatment period will last up to 52 weeks, with the total duration of the study for each participant extending up to 62 weeks.
In January 2025, ArthroBiologix Inc. initiated a study to investigate whether observing the preparatory steps of intra-articular platelet-rich plasma (PRP) injections influences the outcomes for knee osteoarthritis patients. The study aims to determine if patients who watch the steps involved in administering PRP experience better treatment effectiveness compared to those who do not observe the procedure's preparatory steps.
Key Osteoarthritis companies such as Biosplice Therapeutics, Cynata Therapeutics, Bone Therapeutics S.A, Regeneron Pharmaceuticals, Techfields Pharma, Ampio Pharmaceuticals, Asahi Kasei Pharma, Taiwan Bio Therapeutics, OliPass Corporation, Bioventus, Medipost, LG Chem, ICM Biotech, Cells for Cells SA, GWOXI Stem Cell Applied Technology, UnicoCell Biomed, Magellan Biologicals, Levicept, Arthrogen, Personalized Stem Cells, Peptinov, Orient Europharma, ZYUS Life Sciences, Lubris Biopharma, Saol Therapeutics, Ageless Biotech, Synartro AB, Plakous Therapeutics, Ribomic, Meluha Therapeutics, and others are evaluating new drugs for Osteoarthritis to improve the treatment landscape.
Promising Osteoarthritis pipeline therapies in various stages of development include Lorecivivint, EP-104IAR, DFV890, 4P004, GNSC 001, and others.

Osteoarthritis Pipeline Analysis
The report provides insights into:
The report provides detailed insights into the key companies that are developing therapies in the Osteoarthritis Market.
The report also evaluates different therapeutic candidates segmented into early-stage, mid-stage, and late-stage of development for Osteoarthritis treatment.
It analyzes the key companies involved in targeted therapeutics development with respective active and inactive (dormant or discontinued) projects.
It navigates the emerging drugs under development based on the stage of development, route of administration, target receptor, monotherapy or combination therapy, a different mechanism of action, and molecular type.
Detailed analysis of collaborations (company-company collaborations and company-academia collaborations), licensing agreement, and financing details for future advancement of the Osteoarthritis market.

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Osteoarthritis Emerging Drugs

Lorecivivint: Biosplice Therapeutics
EP-104IAR: Eupraxia Pharmaceuticals
DFV890: Novartis
4P004: 4P-Pharma
GNSC 001: Genascence

Osteoarthritis Companies

There are over 100 prominent companies working on developing therapies for osteoarthritis. Among them, Biosplice Therapeutics is one of the companies with osteoarthritis drug candidates in the most advanced stage, specifically Phase III.

DelveInsight's report covers around 110+ products under different phases of clinical development like

Late stage products (Phase III)
Mid-stage products (Phase II)
Early-stage product (Phase I) along with the details of
Pre-clinical and Discovery stage candidates
Discontinued & Inactive candidates

Osteoarthritis pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as

Intravenous
Subcutaneous
Oral
Intramuscular

Osteoarthritis Products have been categorized under various Molecule types such as

Monoclonal antibody
Small molecule
Peptide

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Osteoarthritis Pipeline Therapeutic Assessment
• Osteoarthritis Assessment by Product Type
• Osteoarthritis By Stage
• Osteoarthritis Assessment by Route of Administration
• Osteoarthritis Assessment by Molecule Type

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Table of Content

1. Report Introduction
2. Executive Summary
3. Osteoarthritis Current Treatment Patterns
4. Osteoarthritis - DelveInsight's Analytical Perspective
5. Therapeutic Assessment
6. Osteoarthritis Late-Stage Products (Phase-III)
7. Osteoarthritis Mid-Stage Products (Phase-II)
8. Early Stage Products (Phase-I)
9. Pre-clinical Products and Discovery Stage Products
10. Inactive Products
11. Dormant Products
12. Osteoarthritis Discontinued Products
13. Osteoarthritis Product Profiles
14. Osteoarthritis Key Companies
15. Osteoarthritis Key Products
16. Dormant and Discontinued Products
17. Osteoarthritis Unmet Needs
18. Osteoarthritis Future Perspectives
19. Osteoarthritis Analyst Review
20. Appendix
21. Report Methodology

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Contact Info:
Kritika Rehani
krehani@delveinsight.com
info@delveinsight.com
+14699457679

About DelveInsight

DelveInsight is a leading Business Consultant and Market Research firm focused exclusively on life sciences. It supports Pharma companies by providing comprehensive end-to-end solutions to improve their performance.

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