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Antibody Hit Generation and Screening Market in 2024 Detailed Study Analysis
The Global Antibody Hit Generation and Screening Market is expected to grow with a CAGR of 9.78% during the forecast period of 2024-2031.
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Antibody hit generation and screening is a crucial process in biopharmaceuticals, particularly for developing antibody-based therapeutics. This process begins with the creation of a diverse antibody library, followed by screening to identify candidates that can specifically bind to target antigens linked to various diseases. This stage is critical in antibody discovery, often comprising 40% to 50% of R&D costs. It plays a vital role in identifying potential therapeutic antibodies that can be further developed for treating conditions like cancer, autoimmune diseases, and infectious diseases.
Various technologies are employed in antibody hit generation and screening, each contributing to the efficiency and effectiveness of the process. Hybridoma technology, a classical method, involves fusing B cells with myeloma cells to produce monoclonal antibodies. Phage display enables the selection of antibodies from vast libraries displayed on bacteriophages, while yeast display uses yeast cells for screening. Additionally, computational tools are increasingly used to predict antibody-antigen interactions, streamlining the discovery process and enhancing the potential for developing effective treatments.
List of Prominent Players in the Antibody Hit Generation and Screening Market:
• F. Hoffmann-La Roche Ltd.
• AbbVie
• Pfizer
• AstraZeneca
• Novartis
• Eli Lilly
• WuXi AppTec
• Charles River Laboratories
• Syngenta
• BioLegend
• Creative Biolabs
• Eurofins CDMO
• AbCellera
• MorphoSys
• Evelo Biosciences
• Icos Therapeutics
• Argenx
• Kymab
• Alnylam Pharmaceuticals
• SAb Biotherapeutics
• Other Prominent Players
Market Dynamics:
Drivers-
The antibody hit generation and screening market is being driven by several key factors: the increasing prevalence of chronic diseases like cancer and autoimmune disorders, which heightens the demand for effective antibody-based therapeutics; advancements in technologies such as phage display and computational tools, enabling the discovery of more potent antibody candidates; rising investments in biopharmaceutical R&D, which are accelerating innovation and therapy development; the growing demand for personalized medicine, necessitating diverse antibody libraries tailored to specific patient needs; and the overall expansion of the biopharmaceutical industry, supported by an aging population and unmet medical needs.
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Challenges:
Identifying specific and potent antibodies requires advanced technologies and robust assays to screen large libraries, while improving antibody affinity and stability through affinity maturation is time-consuming and demands specialized expertise. Additionally, developing functional assays that are sensitive, reproducible, and scalable for high-throughput screening is critical but complex in ensuring the desired activity of antibodies.
Regional Trends:
North America's leadership in the Antibody Hit Generation and Screening Market is driven by its strong biopharmaceutical industry, substantial R&D investments, and the presence of major players like F. Hoffmann-La Roche and WuXi AppTec. The region's high prevalence of chronic diseases fuels the demand for innovative antibody therapies, while the growing trend toward personalized medicine necessitates tailored antibody treatments. Additionally, a supportive regulatory environment, with clear guidelines from bodies like the FDA, accelerates the development and approval of new antibody-based drugs, solidifying North America's dominance in this sector.
Recent Developments:
• In May 2024, The SUPERNOVA Phase III trial showed AstraZeneca's sipavibart (formerly AZD3152), a long-acting antibody, significantly reduced symptomatic COVID-19 incidence in immunocompromised patients compared to control. The trial met both primary endpoints, demonstrating sipavibart's efficacy against various SARS-CoV-2 variants, including those without the F456L mutation.
• In May 2024, AstraZeneca plans to build a $1.5 billion manufacturing facility in Singapore for producing antibody-drug conjugates (ADCs), its first end-to-end ADC production site. Supported by the Singapore Economic Development Board, the facility will enhance AstraZeneca's capabilities in developing cancer-killing drugs. The company did not disclose details on potential government incentives.
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Segmentation of Antibody Hit Generation and Screening Market-
By Application:
• Cancer
• Autoimmune diseases
• Infectious diseases
By Technologies:
• Hit Generation
• Phage display
• Yeast display
• Ribosome display
• B-cell hybridoma technology
• Computational tools
• Screening
By Antibody Type:
• Humanized Antibody
• Human Antibody
• Chimeric Antibody
• Murine Antibody
By Region-
North America-
• The US
• Canada
• Mexico
Europe-
• Germany
• The UK
• France
• Italy
• Spain
• Rest of Europe
Asia-Pacific-
• China
• Japan
• India
• South Korea
• South East Asia
• Rest of Asia Pacific
Latin America-
• Brazil
• Argentina
• Rest of Latin America
Middle East & Africa-
• GCC Countries
• South Africa
• Rest of Middle East and Africa
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