Brain Cancer Market is set for steady Growth, with a robust CAGR anticipated by 2034, estimates DelveInsight | Orbus Therapeutics, Kazia Therapeutics, Bayer, MedImmune, Immunomic Therapeutics, Kintara Therapeutics

DelveInsight's "Brain Cancer Market Insights, Epidemiology, and Market Forecast - 2034" report delivers an in-depth understanding, historical and forecasted epidemiology, as well as the Brain Cancer market trends in the United States, EU4 (Germany, France, Italy, and Spain) and the United Kingdom, and Japan.

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Key Takeaways from the Brain Cancer Market Report
• Among the 7MM, the US accounted for the highest incident cases of primary brain tumors in 2023, with around 23,000 cases; these numbers are expected to increase during the forecast period.
• According to the estimates, in the US, it is observed that brain tumor was most incident in the 40-64 years age group, followed by ≥65 years.
• Among the type-specific cases, the cases of Glioblastoma Multiforme accounted for the highest number of incident cases in 2023 in the US.
• Amongst EU4 and the UK, Italy accounted for the highest number of incident cases of the primary brain tumor, followed by Germany in 2023.
• The leading Brain Cancer Companies such as Orbus Therapeutics, Kazia Therapeutics, Bayer, MedImmune, Immunomic Therapeutics, Kintara Therapeutics, Medicenna Therapeutics, Servier, Genentech, Merck, Arbor Pharmaceuticals, Daiichi Sankyo, and others.
• Promising Brain Cancer Pipeline Therapies such as Nivolumab, Temozolomide, GLIADEL, hCRF, Afatinib, Dexanabinol, Dotarem®, HLX208, and others.

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Brain Cancer Epidemiology Segmentation in the 7MM
• Total incident cases of Primary Brain Tumors
• Brain Cancer Type-specific incident cases
• Brain Cancer Gender-specific incident cases
• Brain Cancer Grade-specific incident cases
• Brain Cancer Age-specific Distribution

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Brain Cancer Marketed Drugs
• AVASTIN (bevacizumab): Genentech
AVASTIN is a recombinant humanized monoclonal IgG1 antibody, which acts as an angiogenesis inhibitor by blocking its target, vascular endothelial growth factor. It binds to the vascular endothelial growth factor with its receptors VEGFR-1 and VEGFR-2, which are present on the surface of endothelial cells. This helps in reducing the activity of VEGF and regressing the vascularization of tumors. AVASTIN is indicated for the treatment of glioblastoma with progressive disease in adult patients following prior therapy as a single agent.

• TEMODAR/TEMODAL: Merck
The active pharmaceutical ingredient in TEMODAR/TEMODAL is an imidazotetrazine derivative of the alkylating agent dacarbazine. It is used for the treatment of several brain cancer forms, e.g., as a second-line treatment for astrocytoma and as a first-line treatment for glioblastoma. The therapeutic benefit is due to its ability to alkylate/methylate DNA. This alkylation/methylation destroys the DNA and triggers the death of the tumor cells. Temozolomide targets selectively tumoral tissues; it has an anti-neoplastic effect; it has minimum influence on adjacent brain tissues; it has no severe systemic toxicity, and it is eliminated rapidly. It was granted US FDA approval in the treatment of recurrent anaplastic astrocytoma in 1999.

Brain Cancer Emerging Drugs
• Vorasidenib: Servier
Vorasidenib is a small molecule and is a dual inhibitor of mutant isocitrate dehydrogenase 1 and 2 (IDH1/2) enzymes in development for the treatment of IDH-mutant diffuse glioma. Vorasidenib works as a brain penetrant. It was granted Fast Track Designation in February 2023 and Breakthrough Therapy Designation in August 2023 by the US FDA. In the Phase III INDIGO trial (NCT04164901), vorasidenib demonstrated reduced tumor growth rate (TGR) and shrunk tumor volume, as measured by an independent radiology committee, while patients in the placebo arm saw continued growth in tumor volume.

• Paxalisib: Kazia Therapeutics
Paxalisib is a small molecule that inhibits PI3K, a critical control mechanism in growth and cell division, which is activated in many forms of cancer. Paxalisib has been designed to cross the blood-brain barrier, and a wealth of experimental data shows that it does so very successfully. This feature of paxalisib is almost unique in this class of medicines and differentiates it from the approved products in the PI3K inhibitor class. The lead indication for paxalisib is glioblastoma.

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Brain Cancer Treatment Market
The treatment often comprises a combination of several therapies, including surgery, chemotherapy, radiation, or stereotactic radiosurgery followed by additional/adjuvant treatments, such as chemotherapy or radiation therapy, after surgery. Treatment is palliative and may include surgery, radiation therapy, and/or chemotherapy. Immunotherapy provides another opportunity for treatment in the market.

Scope of the Brain Cancer Market Report
• Coverage- 7MM
• Brain Cancer Companies- Orbus Therapeutics, Kazia Therapeutics, Bayer, MedImmune, Immunomic Therapeutics, Kintara Therapeutics, Medicenna Therapeutics, Servier, Genentech, Merck, Arbor Pharmaceuticals, Daiichi Sankyo, and others.
• Brain Cancer Pipeline Therapies- Nivolumab, Temozolomide, GLIADEL, hCRF, Afatinib, Dexanabinol, Dotarem®, HLX208, and others
• Brain Cancer Market Dynamics: Brain Cancer Market Drivers and Barriers
• Brain Cancer Market Access and Reimbursement, Unmet Needs and Future Perspectives

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Table of Content
1 Key Insights
2 Report Introduction
3 Executive Summary
4 Brain Cancer Market Overview at a Glance
5 Key Events
6 Epidemiology and Market Forecast Methodology
7 Disease Background and Overview
8 Treatment
9 Treatment Algorithm
10 Epidemiology and Patient Population
11 Patient Journey
12 Marketed Drugs
13 Emerging Therapies
14 Brain Cancer: Seven Major Market Analysis
15 Unmet Needs
16 SWOT Analysis
17 KOL Views
18 Reimbursement and Market Access
19 Appendix
20 DelveInsight Capabilities
21 Disclaimer
22 About DelveInsight

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