Hypertension Clinical and Non-Clinical Studies, Key Companies, Therapeutic Assessment, Emerging Therapies, Treatment Algorithm, and Pipeline Analysis | Gossamer Bio, Addpharma Inc., Insmed Incorporated, Alnylam Pharmaceuticals, 35Pharma Inc, Pfizer, Pharm

Hypertension Pipeline constitutes 80+ key companies continuously working towards developing 100+ Hypertension treatment therapies, analyzes DelveInsight.

Hypertension Overview:

Hypertension, or high blood pressure, is a chronic condition characterized by increased pressure in the arteries, which can lead to serious health issues if left untreated. It is categorized into primary hypertension, which has no known cause and typically develops gradually over time, and secondary hypertension, which results from another underlying condition such as kidney disease or hormonal imbalances. Hypertension is a significant risk factor for cardiovascular diseases, including heart attacks and strokes, as well as kidney damage and vision loss. Often called the "silent killer," hypertension may not show clear symptoms, especially in its early stages, making regular monitoring crucial. When symptoms do appear, they may include headaches, dizziness, shortness of breath, nosebleeds, and palpitations. In severe cases, individuals might experience blurred vision, chest pain, or fatigue, which could signal damage to the heart or other organs. Many people with hypertension can remain symptom-free for years, emphasizing the importance of routine blood pressure checks to detect the condition early and prevent severe health complications.

The pathology of hypertension involves complex interactions between genetic, environmental, and physiological factors that result in sustained high blood pressure. A key factor in this process is dysfunction in the vascular system, particularly the endothelium, which regulates blood flow and vascular tone. In hypertension, oxidative stress, inflammation, and abnormal production of vasoactive substances (such as endothelin and nitric oxide) contribute to endothelial dysfunction and increased vascular resistance. Additionally, neurohumoral mechanisms, including the renin-angiotensin-aldosterone system (RAAS) and activation of the sympathetic nervous system, are crucial in promoting vasoconstriction and fluid retention.

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"Hypertension Pipeline Insight 2024" report by DelveInsight provides a comprehensive analysis of the ongoing clinical development activities and growth prospects across the Hypertension Therapeutics Market.

Key Takeaways from the Hypertension Pipeline Report

DelveInsight's Hypertension pipeline report depicts a robust space with 80+ active players working to develop 100+ pipeline therapies for Hypertension treatment.
In December 2024, Nicox revealed that its Denali Phase III trial, assessing the efficacy and safety of NCX470 in patients with open-angle glaucoma or ocular hypertension, has reached full enrollment in China, with screening now closed.
In November 2024, MediPrint Ophthalmics shared the results of its Phase IIb clinical trial of LL-BMT1. This trial used a novel 3D-printed, drug-eluting contact lens to deliver bimatoprost and hyaluronic acid for sustained release, achieving all Phase IIb endpoints.
In October 2023, SpyGlass Pharma announced the start of a Phase I/II clinical trial to investigate its intraocular drug delivery platform in patients with glaucoma and visually significant cataracts. The SpyGlass platform, designed for implantation during routine cataract surgery, aims to deliver multiple years of bimatoprost to lower intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension.
In April 2024, Qlaris Bio completed a $24 million Series B financing round to further develop QLS‑111, a first-in-class IOP-lowering drug candidate for glaucoma.
Also in April 2024, Qlaris Bio announced the launch and dosing of two separate Phase II masked, randomized clinical trials in the U.S., investigating QLS‑111 in patients with ocular hypertension and glaucoma.
In March 2024, Nicox published the results from its Mont Blanc pivotal Phase III trial comparing NCX 470 to latanoprost for lowering intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension in the peer-reviewed *American Journal of Ophthalmology*.
Key Hypertension companies such as Gossamer Bio, Addpharma Inc., Insmed Incorporated, Alnylam Pharmaceuticals, 35Pharma Inc, Pfizer, Pharmosa Biopharm Inc., Guangzhou Magpie Pharmaceuticals Co., Ltd., Suzhou Sanegene Bio Inc., JW Pharmaceutical, and others are evaluating new drugs for Hypertension to improve the treatment landscape.
Promising Hypertension pipeline therapies in various stages of development include Seralutinib, AD-209, Zilebesiran, LAM-001, HS135, and others.

Hypertension Pipeline Analysis
The report provides insights into:
The report provides detailed insights into the key companies that are developing therapies in the Hypertension Market.
The report also evaluates different therapeutic candidates segmented into early-stage, mid-stage, and late-stage of development for Hypertension treatment.
It analyzes the key companies involved in targeted therapeutics development with respective active and inactive (dormant or discontinued) projects.
It navigates the emerging drugs under development based on the stage of development, route of administration, target receptor, monotherapy or combination therapy, a different mechanism of action, and molecular type.
Detailed analysis of collaborations (company-company collaborations and company-academia collaborations), licensing agreement, and financing details for future advancement of the Hypertension market.

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Hypertension Emerging Drugs

Seralutinib: Gossamer Bio
AD-209: Addpharma Inc.
Zilebesiran: Alnylam Therapeutics
LAM-001: ORPHAI THERAPEUTICS
HS135: 35Pharma Inc.

Hypertension Companies

Over 80 major companies are working on developing therapies for hypertension. Among them, Gossamer Bio and Addpharma Inc. have drug candidates for hypertension that are in the most advanced stage, namely Phase III.

DelveInsight's report covers around 100+ products under different phases of clinical development like

Late stage products (Phase III)
Mid-stage products (Phase II)
Early-stage product (Phase I) along with the details of
Pre-clinical and Discovery stage candidates
Discontinued & Inactive candidates

Hypertension pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as

Intravenous
Subcutaneous
Oral
Intramuscular

Hypertension Products have been categorized under various Molecule types such as

Monoclonal antibody
Small molecule
Peptide

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Hypertension Pipeline Therapeutic Assessment
• Hypertension Assessment by Product Type
• Hypertension By Stage
• Hypertension Assessment by Route of Administration
• Hypertension Assessment by Molecule Type

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Table of Content

1. Report Introduction
2. Executive Summary
3. Hypertension Current Treatment Patterns
4. Hypertension - DelveInsight's Analytical Perspective
5. Therapeutic Assessment
6. Hypertension Late-Stage Products (Phase-III)
7. Hypertension Mid-Stage Products (Phase-II)
8. Early Stage Products (Phase-I)
9. Pre-clinical Products and Discovery Stage Products
10. Inactive Products
11. Dormant Products
12. Hypertension Discontinued Products
13. Hypertension Product Profiles
14. Hypertension Key Companies
15. Hypertension Key Products
16. Dormant and Discontinued Products
17. Hypertension Unmet Needs
18. Hypertension Future Perspectives
19. Hypertension Analyst Review
20. Appendix
21. Report Methodology

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Contact Info:
Kritika Rehani
krehani@delveinsight.com
info@delveinsight.com
+14699457679

About DelveInsight

DelveInsight is a leading Business Consultant and Market Research firm focused exclusively on life sciences. It supports Pharma companies by providing comprehensive end-to-end solutions to improve their performance.

This release was published on openPR.