USC Biochemistry Graduate Student Aaliyah S. Tyson Challenges Traditional G-Protein Coupled Receptor Pharmacotherapy Principles in her First Published White Paper

"Molecular mechanisms of inverse agonism via k-opioid receptor-G protein complexes" was published by Nature Chemical Biology and can be reviewed now at Nature.com
Aaliyah S. Tyson, a pioneering young biochemistry student at USC, has just been featured in her first publication. The white paper titled "Molecular mechanisms of inverse agonism via k-opioid receptor-G protein complexes" was published in Nature Chemical Biology by a swath of authors, with Tyson at the helm.

Tyson graduated from Loyola Marymount University in 2022 with a B.S. in Biochemistry. She is currently pursuing her doctorate degree at USC, where she is completing her graduate research at the Gati lab. She has taken Advanced Chemical Biology, Biological Therapeutics, Cellular and Molecular Neuroscience, Multi-Scale Imaging, and Neuropsychopharmacology. Tyson's current research centers around using cryoEm to investigate GPCR structure on an atomic scale to identify connections between interactions with ligands and signaling partners, as well as the pharmacological properties of such receptors.

Image: https://www.globalnewslines.com/uploads/2025/01/962ffb6a15c7aeec40739d7d09f06ba2.jpg

Nature Chemical Biology is a peer-reviewed scientific journal that focuses on chemical biology while providing a platform where scientists and researchers can share their data and insights. Nature Chemical Biology is a sought-after publication for researchers who are looking to publish their white papers and articles. All published material is required to go through a rigorous submissions process before approval.

"Molecular mechanisms of inverse agonism via k-opioid receptor-G protein complexes," was written by Tyson, Saif Khan, Zenia Motiwala, Gye Won Han, Zixin Zhang, Mohsen Ranjbar, Daniel Styrpejko, Nokomis Ramos-Gonzalez, Stone Woo, Kelly Villers, Delainey Landaker, Terry Kenakin, Ryan Shenvi, Susruta Majumdar, and Corenlius Gati. The paper's abstract explains the nature of opioid receptors before explaining the goal of the group's research. "In summary, our work challenges the canonical model of receptor antagonism and offers crucial insights into GPCR pharmacology."

GPCR pharmacology specifically studies how drugs interact with G protein-coupled receptors, which are the largest family of cell surface receptors. These receptors are a target for many FDA-approved drugs. The work carried out by Tyson and her team has the potential to aid in the creation of the next generation of safer and more effective pharmacological treatments.

The full paper can be seen in Nature Chemical Biology as well as at https://www.nature.com/articles/s41589-024-01812-0.

ABOUT AALIYAH S. TYSON

Aaliyah S. Tyson graduated with a B.S. in Biochemistry from Loyola Marymount University in 2022 and is currently pursuing her doctorate at USC, where she is completing her graduate research at the Gati lab.
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