Glioblastoma Clinical and Non-Clinical Studies, Key Companies, Therapeutic Assessment, Emerging Therapies, Treatment Algorithm, and Pipeline Analysis | Denovo Biopharma, Cantex Pharmaceuticals, CNS Pharmaceuticals, CANbridge Pharmaceuticals, Vaximm, Inovi

Glioblastoma Pipeline constitutes 180+ key companies continuously working towards developing 200+ Glioblastoma treatment therapies, analyzes DelveInsight.

Glioblastoma Overview:

Glioblastoma Multiforme (GBM) is the most common type of primary brain tumor in adults, and its prognosis remains poor despite advancements in diagnostic techniques and new treatments. Cancer progression is driven by somatic evolution, where the genome of cancer cells diverges from that of healthy cells due to the accumulation of mutations. GBM develops through a complex network of various molecular and genetic alterations, resulting in significant changes to key signaling pathways. Its aggressive nature is exacerbated by widespread dispersion throughout the brain tissue, making complete surgical removal difficult, and its high vascularization contributes to its lethal behavior. GBM is characterized by nonspecific symptoms such as headaches, personality changes, nausea, and stroke-like symptoms. Neurological symptoms like headaches, vomiting, seizures, cognitive dysfunction, and focal neurological deficits, as well as cranial nerve dysfunction, are common, while rare cases may present with vertigo or psychiatric symptoms. GBM accounts for 52% of all primary brain tumors and 20% of all intracranial tumors, making it the most common and aggressive form of primary brain cancer.

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"Glioblastoma Pipeline Insight 2024" report by DelveInsight provides a comprehensive analysis of the ongoing clinical development activities and growth prospects across the Glioblastoma Therapeutics Market.

Key Takeaways from the Glioblastoma Pipeline Report

DelveInsight's Glioblastoma pipeline report depicts a robust space with 180+ active players working to develop 200+ pipeline therapies for Glioblastoma treatment.
In March 2024, Laminar Pharmaceuticals revealed a Phase 2 clinical trial for LAM561 and TMZ. The planned Phase IIB/III randomized, double-blind, placebo-controlled study in patients with newly diagnosed primary glioblastoma multiforme (ndGBM) seeks to evaluate the efficacy and safety of LAM561 versus placebo, in combination with the standard treatment of radiation therapy and temozolomide (TMZ). This will be followed by a six-month adjuvant treatment period with TMZ and then LAM561 or placebo as monotherapy.
In March 2024, TVAX Biomedical announced Phase 2 and 3 clinical trials for Temozolomide. This randomized study aims to compare the combination of TVI-Brain-1 immunotherapy with standard therapy against standard therapy alone for newly diagnosed MGMT unmethylated glioblastoma patients. The treatment involves using the patient's own cancer cells, collected post-surgery, to create a vaccine that stimulates an immune response, significantly boosting the number of cancer neoantigen-specific effector T cell precursors in the patient's body.
Key Glioblastoma companies such as Denovo Biopharma, Cantex Pharmaceuticals, CNS Pharmaceuticals, CANbridge Pharmaceuticals, Vaximm, Inovio Pharmaceuticals, Mustang Bio, Bullfrog AI Holdings, Cantex, Chimeric Therapeutics, Philogen, Boehringer Ingelheim, Photonamic GmbH, Berg Pharma, Beyond Bio, Genenta Science, Polaris Pharmaceuticals, Telix Pharmaceuticals, Shanghai Simnova Biotechnology, NEONC Technologies, and others are evaluating new drugs for Glioblastoma to improve the treatment landscape.
Promising Glioblastoma pipeline therapies in various stages of development include Enzastaurin, Asunercept, Berubicin, VXM01, Azeliragon, MB-101, and others.

Glioblastoma Pipeline Analysis
The report provides insights into:
The report provides detailed insights into the key companies that are developing therapies in the Glioblastoma Market.
The report also evaluates different therapeutic candidates segmented into early-stage, mid-stage, and late-stage of development for Glioblastoma treatment.
It analyzes the key companies involved in targeted therapeutics development with respective active and inactive (dormant or discontinued) projects.
It navigates the emerging drugs under development based on the stage of development, route of administration, target receptor, monotherapy or combination therapy, a different mechanism of action, and molecular type.
Detailed analysis of collaborations (company-company collaborations and company-academia collaborations), licensing agreement, and financing details for future advancement of the Glioblastoma market.

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Glioblastoma Emerging Drugs

Enzastaurin: Denovo BioPharma
Asunercept: Apogenix
Berubicin: CNS Pharmaceuticals
VXM01: VAXIMM
Azeliragon: Cantex
MB-101: Mustang Bio

Glioblastoma Companies

There are over 180 key companies working on developing therapies for Glioblastoma. Among these, the companies with Glioblastoma drug candidates in the most advanced stage, Phase III, include Denovo.

DelveInsight's report covers around 200+ products under different phases of clinical development like

Late stage products (Phase III)
Mid-stage products (Phase II)
Early-stage product (Phase I) along with the details of
Pre-clinical and Discovery stage candidates
Discontinued & Inactive candidates

Glioblastoma pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as

Intravenous
Subcutaneous
Oral
Intramuscular

Glioblastoma Products have been categorized under various Molecule types such as

Monoclonal antibody
Small molecule
Peptide

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Glioblastoma Pipeline Therapeutic Assessment
• Glioblastoma Assessment by Product Type
• Glioblastoma By Stage
• Glioblastoma Assessment by Route of Administration
• Glioblastoma Assessment by Molecule Type

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Table of Content

1. Report Introduction
2. Executive Summary
3. Glioblastoma Current Treatment Patterns
4. Glioblastoma - DelveInsight's Analytical Perspective
5. Therapeutic Assessment
6. Glioblastoma Late-Stage Products (Phase-III)
7. Glioblastoma Mid-Stage Products (Phase-II)
8. Early Stage Products (Phase-I)
9. Pre-clinical Products and Discovery Stage Products
10. Inactive Products
11. Dormant Products
12. Glioblastoma Discontinued Products
13. Glioblastoma Product Profiles
14. Glioblastoma Key Companies
15. Glioblastoma Key Products
16. Dormant and Discontinued Products
17. Glioblastoma Unmet Needs
18. Glioblastoma Future Perspectives
19. Glioblastoma Analyst Review
20. Appendix
21. Report Methodology

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Contact Info:
Kritika Rehani
krehani@delveinsight.com
info@delveinsight.com
+14699457679

About DelveInsight

DelveInsight is a leading Business Consultant and Market Research firm focused exclusively on life sciences. It supports Pharma companies by providing comprehensive end-to-end solutions to improve their performance.

This release was published on openPR.