Global Polyclonal Antibodies Market to Reach US$ 2.74 Billion by 2034, Driven by Rising Disease Incidences

The global market for polyclonal antibodies is projected to grow from US$ 1.68 billion in 2024 to US$ 2.74 billion by 2034, expanding at a CAGR of 5.04%. This growth is being driven by the rising incidence of various diseases, which boosts the demand for both diagnostic tools and therapeutic treatments involving polyclonal antibodies.

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What Are Polyclonal Antibodies?

Polyclonal antibodies (pAbs) are produced by the immune system's B cells and consist of a diverse mix of antibodies targeting multiple epitopes on the same antigen. Unlike monoclonal antibodies, which are designed to target a single epitope, polyclonal antibodies can bind to different parts of an antigen. These antibodies are essential tools in research, diagnostics, and even therapeutic applications, including their use in food processing quality control and human/veterinary medicine.

Key Trends Shaping the Market

• Investment in Research and Manufacturing: In November 2024, Sanofi committed €40 million (US$42 million) to enhance its bioproduction facility in Lyon, France, with €25 million (US$26 million) earmarked for the research and production of Thymoglobulin-a polyclonal antibody used in transplant treatment.

• Innovative Acquisitions: In October 2024, EQT Life Sciences acquired ATB Therapeutics, a company focused on developing novel polyclonal antibodies. This acquisition was part of a €54 million fundraising round to advance the development of new antibody therapies.

AI in Antibody Development

AI technologies are beginning to play a significant role in antibody research. AI tools can predict how well antibodies will enter cells and assess critical factors like toxicity, immunogenicity, solubility, and half-life. This capability helps streamline drug development, making the process faster and more cost-effective.

For instance, Antiverse, a techbio startup, raised €4.2 million in a seed funding round in October 2024 to support the development of generative AI for designing antibodies. This marks a significant step forward in using AI to tackle difficult antibody targets.

Market Dynamics

Driver: Rising Demand for Diagnostics and Treatments

The increasing prevalence of chronic diseases like cancer, autoimmune disorders, and infections is driving demand for polyclonal antibodies in both diagnostics and therapeutics. Their ability to bind to specific target molecules makes them ideal for these applications, and advancements in antibody production technologies, such as hybridoma technology and transgenic animals, further fuel market growth.

Restraint: Limited Specificity

A challenge in the polyclonal antibodies market is their limited specificity. Since polyclonal antibodies recognize multiple epitopes, they can sometimes bind to unintended targets, leading to issues like cross-reactivity. This can affect experimental results and lead to false positives in diagnostic tests. Additionally, off-target effects in therapies could cause unwanted patient responses.

Opportunity: Targeted Therapies in Development

The market for antibody-based therapies is booming, with some of the fastest-growing pharmaceutical products in the U.S. focused on treating cancer, autoimmune diseases, and infections. One exciting opportunity lies in targeted therapy and precision oncology, which aim to precisely target cancer-related molecules, improving the effectiveness of treatment while minimizing side effects. Many of these therapies are still in clinical trials, but some have already been approved by the FDA.

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Segment Insights

Secondary Antibodies Lead the Market

In 2024, secondary antibodies dominated the polyclonal antibodies market. These antibodies are crucial in various immunohistochemical and immunoassay procedures, both in research and diagnostics. Secondary antibodies are essential for a range of lab tests like flow cytometry, immunofluorescence, Western Blot (WB), and Enzyme-Linked Immunosorbent Assay (ELISA). Their conjugated properties enhance detection methods, particularly in diagnosing diseases like autoimmune disorders, where they help identify autoantibodies and antibodies related to tissue antigens.

Primary Antibodies: The Fastest-Growing Segment

The primary antibodies segment is expected to experience the fastest growth in the polyclonal antibodies market from 2025 to 2034. These antibodies are vital for identifying specific proteins or antigens in biological samples. They play an essential role in scientific research and diagnostics by improving the sensitivity and specificity of disease detection and treatment development.

Diagnostics Drive the Market

In 2024, diagnostics applications led the polyclonal antibodies market. Polyclonal antibodies are highly effective in diagnostic tests because they can bind to multiple epitopes on target molecules, which enhances their ability to identify unknown antigens. Their key role in immunoassays such as ELISA, western blotting, and immunohistochemistry helps improve detection and diagnosis of diseases.

Biomedical Research: High Growth Potential

The biomedical research segment is expected to see significant growth over the next decade. Polyclonal antibodies are crucial tools for identifying proteins in complex samples and locating proteins in tissues through methods like western blotting and immunohistochemistry. Their use in research continues to expand, helping scientists better understand biological processes and diseases. As biotechnology advances, the development of polyclonal antibodies will continue to evolve, enabling breakthroughs in both research and treatment.

Rabbit Segment Leads the Market

The rabbit segment accounted for the largest share of the polyclonal antibodies market in 2024. Rabbits are commonly used in laboratories for antibody production due to their large size, ease of blood collection, and strong immune response to a wide range of antigens. Their ability to generate high-quality polyclonal antibodies has made them a staple in many research and diagnostic settings.

Mouse Segment Shows Rapid Growth

The mouse segment is anticipated to grow at the fastest rate in the coming years. Mice are widely used in research due to their availability and the efficiency with which they can produce antibodies against various antigens. Their use in generating polyclonal antibodies is expected to expand as research and development needs grow.

Hospitals & Diagnostic Centers Lead End-Use Applications

In 2024, hospitals and diagnostic centers were the largest end-users of polyclonal antibodies. These antibodies are widely employed in diagnosing various diseases, and their use is growing as the demand for accurate diagnostics rises. Hospitals and diagnostics centers are key drivers of this market, providing essential services for patient care.

Pharmaceutical & Biotechnology Companies: Significant Growth

The pharmaceutical and biotechnology sectors are expected to grow significantly in the polyclonal antibodies market. These antibodies are used not only for diagnosis but also for developing new treatments. Pharmaceutical companies rely on polyclonal antibodies in the development of therapeutic products, while biotechnology companies focus on research and genetic engineering of these antibodies to address various health challenges.

Regional Insights

North America Leads the Market

In 2023, North America dominated the polyclonal antibodies market, holding a 39% share. The region's strong biotechnology sector, high healthcare spending, and robust research infrastructure have made it a leader in the development and application of polyclonal antibody treatments. Additionally, North America's favorable regulatory environment and strategic collaborations among government, academia, and industry continue to drive innovation and market growth.

Asia Pacific: The Fastest-Growing Region

Asia Pacific is projected to be the fastest-growing region in the polyclonal antibodies market during the forecast period. The rising prevalence of chronic conditions, including autoimmune diseases, along with increasing healthcare spending in countries like China and India, is fueling market expansion. The region is home to growing pharmaceutical and biotechnology industries, supported by favorable government policies that encourage research and development.

Latest Announcements by Industry Leaders

Grifols and GigaGen Partnership
• In October 2024, Grifols announced its continued collaboration with the U.S. government to develop therapies for biological threats. GigaGen, with its exclusive recombinant polyclonal antibody platform, is working to revolutionize the treatment of infectious diseases.

Fabentech Secures Funding
• Fabentech, in October 2024, secured €20 million in venture loan funding from the European Investment Bank. This investment will support the development of FabShield polyclonal antibody therapies, under the HERA program.

Bio-Rad Expands Services
• In July 2024, Bio-Rad Laboratories announced the expansion of its Pioneer™ Antibody Discovery Platform services, marking a significant step forward in supporting clinical diagnostics and life sciences research.

Top Companies in the Polyclonal Antibodies Market

• Thermo Fisher Scientific Inc.
• Merck KGaA
• Abcam plc.
• ProteoGeni
• Proteintech Group, Inc.
• Bio-Rad Laboratories Inc.
• BPS Bioscience, Inc.
• R&D Systems, Inc.
• Agilent Technologies, Inc.
• Atlas Antibodies
• CUSABIO TECHNOLOGY LLC
• ROCKLAND IMMUNOCHEMICALS, INC.

Segments Covered in the Report

By Product

• Secondary Antibodies
• Primary Antibodies

By Application

• Diagnostics
• Biomedical Research

By Source

• Rabbit
• Mouse
• Goat
• Sheep
• Others

By End-User

• Hospitals & Diagnostic Centers
• Pharmaceutical & Biotechnology Companies
• Academic & Research Center

By Region

• North America
o U.S.
o Canada
• Asia Pacific
o China
o Japan
o India
o South Korea
o Thailand
• Europe
o Germany
o UK
o France
o Italy
o Spain
o Sweden
o Denmark
o Norway
• Latin America
o Brazil
o Mexico
o Argentina
• Middle East and Africa (MEA)
o South Africa
o UAE
o Saudi Arabia
o Kuwait

Source: https://www.towardshealthcare.com/insights/polyclonal-antibodies-market-sizing

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