CAR-T Pipeline Therapeutics Assessment Report 2024 (Updated)

DelveInsight's, "CAR-T Pipeline Insight 2024" report provides comprehensive insights about 180+ companies and 200+ pipeline drugs in CAR-T pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

Explore our latest breakthroughs in CAR-T Research. Learn more about our innovative pipeline today! @ CAR-T Pipeline Outlook- https://www.delveinsight.com/sample-request/car-t-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=ypr

Key Takeaways from the CAR-T Pipeline Report
• In November 2024:- Kyverna Therapeutics- KYSA-8: A Phase 2 Open-Label, Single-Arm, Multicenter Study of KYV 101, an Autologous Fully Human Anti-CD19 Chimeric Antigen Receptor T Cell (CD19 CAR T) Therapy, in Subjects With Treatment Refractory Stiff Person Syndrome. Stiff person syndrome (SPS) is a rare progressive immune-mediated disorder of the central nervous system (CNS) that is characterized by progressive rigidity and painful spasms of predominantly axial and proximal limb muscles. The condition gradually worsens over time and left untreated, it can lead to permanent disability and in some cases, mortality.
• In October 2024: Novartis Pharmaceuticals- The purpose of this study is to monitor all patients exposed to CAR-T therapied for 15 years following their last CAR-T (e.g. CTL019) infusion to assess the risk of delayed adverse events (AEs), monitor for replication competent lentivirus (RCL) and assess long-term efficacy, including vector persistence.
• In October 2024:- Janssen Research & Development LLC- A Phase 2, Multicohort Open-Label Study of JNJ-68284528, a Chimeric Antigen Receptor T Cell (CAR-T) Therapy Directed Against BCMA in Subjects With Multiple Myeloma. The purpose of this study is to evaluate the overall minimal residual disease (MRD) negative rate of participants who receive JNJ-68284528.
• DelveInsight's CAR-T pipeline report depicts a robust space with 180+ active players working to develop 200+ pipeline therapies for CAR-T treatment.
• The leading CAR-T Companies such as Caribou Biosciences, Allogene Therapeutics, Synthekine, Shanghai Simnova Biotechnology, Sana Biotechnology, Zhejiang University, Janssen Research & Development, Beijing Immunochina Medical Science & Technology, M.D. Anderson Cancer Center, SecuraBio, CARsgen Therapeutics, Atara Biotherapeutics, Wugen, Vor Biopharma, Juventas Cell Therapy, Hebei Senlang Biotechnology, Cellular Biomedicine Group, Oncternal Therapeutics, Autolus Limited, Lyell Immunopharma, Gracell Biopharmaceuticals, and others.
• Promising CAR-T Therapies such as IM23, C-CAR066, AJMUC1- PD-1 gene knockout anti-MUC1 CAR-T cells, Fludarabine, Cyclophosphamide, and others.

Stay informed about the cutting-edge advancements in CAR-T treatments. Download for updates and be a part of the revolution in care @ CAR-T Clinical Trials Assessment- https://www.delveinsight.com/sample-request/car-t-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=ypr

CAR-T Emerging Drugs Profile

• Descartes-08: Cartesian Therapeutics
Descartes-08 is an autologous anti-B cell maturation antigen (BCMA) mRNA CAR-T. Compared to conventional DNA-based CAR T-cell therapies, mRNA CAR-T is designed not to require preconditioning chemotherapy, has been observed to have predictable and controllable pharmacokinetics, and is designed to avoid the risk of genomic integration. Descartes-08 has been granted Orphan Drug Designation by the US FDA for the treatment of MG, a chronic autoimmune disorder that causes disabling muscle weakness and fatigue. Currently, the drug is in Phase II stage of clinical trial for the treatment of autoimmune disorders.

• KYV-101: Kyverna Therapeutics
KYV-101 is an autologous, fully human CD19 CAR T-cell product candidate for use in B cell-driven autoimmune diseases. The CAR in KYV-101 was designed by the National Institutes of Health (NIH) to improve tolerability and tested in a 20-patient Phase 1 trial in oncology. Results were published by the NIH in Nature Medicine3. KYV-101 is currently being evaluated in sponsored, open-label, Phase 1/2 trials of KYV-101 in patients with lupus nephritis, an autoimmune disease in which more than half of patients do not achieve a complete response to current therapies and are at risk of developing kidney failure. Additionally, FDA's IND clearance has been obtained for Phase 2 trials of KYV-101 for multiple sclerosis and myasthenia gravis, and a Phase I/II trial for systemic sclerosis.

• TX200: Sangamo Therapeutics
TX200 is composed of the patient's own (autologous) regulatory T cells (Tregs) engineered to express a chimeric antigen receptor (CAR) designed to recognize the HLA-A2 protein present on a transplanted kidney and bind to it. TX200 is in development for the prevention of immune-mediated rejection in HLA-A2 mismatched kidney transplantation from a living donor. It is in Phase I/II stage of its clinical trial.

• ALLO-605: Allogene Therapeutics
ALLO-605, a next-generation AlloCAR T™ known as a TurboCAR™, is an investigational product that targets the B-cell maturation antigen (BCMA) for the treatment of patients with relapsed/refractory multiple myeloma and other BCMA-positive malignancies. This study uses ALLO-647, Allogene's proprietary monoclonal antibody (mAb), as a part of its differentiated lymphodepletion regimen. ALLO-605 incorporates Allogene's proprietary TurboCAR technology, which allows for cytokine activation signaling to be engineered selectively into CAR T cells. In June 2021, ALLO-605 was granted Fast Track designation by the U.S. Food and Drug Administration (FDA) for the potential treatment of relapsed/refractory multiple myeloma. The Phase 1 study evaluating ALLO-605 is underway. Currently, the drug is in Phase I/II stage of its clinical trial for the treatment of Multiple Myeloma.

• ATA3219: Atara Biotherapeutics
ATA3219 combines the natural biology of unedited T cells with the benefits of an allogeneic therapy. It consists of allogeneic Epstein-Barr virus (EBV)-sensitized T cells that express a CD19 CAR construct for the treatment of CD19+ relapsed or refractory B-cell malignancies, including B-cell non-Hodgkin's lymphoma and B-cell mediated autoimmune diseases including systemic lupus erythematosus (SLE) with kidney involvement (lupus nephritis [LN]). ATA3219 has been optimized to offer a potential best-in-class profile, featuring off-the-shelf availability. Currently, the drug is in Phase I stage of its clinical trial.

• CB-010 : Caribou Biosciences
CB-010 is an allogeneic anti-CD19 CAR-T cell therapy for the treatment of patients with relapsed or refractory B cell non-Hodgkin lymphoma (r/r B-NHL). CB-010 is the first allogeneic CAR-T cell therapy, to our knowledge, in a clinical trial with a PD-1 knockout, a genome-editing strategy designed to improve antitumor activity by limiting premature CAR-T cell exhaustion. CB-010 is being evaluated in the ongoing, open-label, multicenter ANTLER Phase I clinical trial in adults with r/r B-NHL.

Learn more about CAR-T Drugs opportunities in our groundbreaking CAR-T Research and development projects @ CAR-T Unmet Needs- https://www.delveinsight.com/sample-request/car-t-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=ypr

CAR-T Companies
Caribou Biosciences, Allogene Therapeutics, Synthekine, Shanghai Simnova Biotechnology, Sana Biotechnology, Zhejiang University, Janssen Research & Development, Beijing Immunochina Medical Science & Technology, M.D. Anderson Cancer Center, SecuraBio, CARsgen Therapeutics, Atara Biotherapeutics, Wugen, Vor Biopharma, Juventas Cell Therapy, Hebei Senlang Biotechnology, Cellular Biomedicine Group, Oncternal Therapeutics, Autolus Limited, Lyell Immunopharma, Gracell Biopharmaceuticals, and others.

CAR-T pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as
• Oral
• Intravenous
• Subcutaneous
• Parenteral
• Topical

CAR-T Products have been categorized under various Molecule types such as
• Recombinant fusion proteins
• Small molecule
• Monoclonal antibody
• Peptide
• Polymer
• Gene therapy

Discover the latest advancements in CAR-T treatment by visiting our website. Stay informed about how we're transforming the future of disease @ CAR-T Market Drivers and Barriers, and Future Perspectives- https://www.delveinsight.com/sample-request/car-t-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=ypr

Scope of the CAR-T Pipeline Report
• Coverage- Global
• CAR-T Companies- Caribou Biosciences, Allogene Therapeutics, Synthekine, Shanghai Simnova Biotechnology, Sana Biotechnology, Zhejiang University, Janssen Research & Development, Beijing Immunochina Medical Science & Technology, M.D. Anderson Cancer Center, SecuraBio, CARsgen Therapeutics, Atara Biotherapeutics, Wugen, Vor Biopharma, Juventas Cell Therapy, Hebei Senlang Biotechnology, Cellular Biomedicine Group, Oncternal Therapeutics, Autolus Limited, Lyell Immunopharma, Gracell Biopharmaceuticals, and others.
• CAR-T Therapies- IM23, C-CAR066, AJMUC1- PD-1 gene knockout anti-MUC1 CAR-T cells, Fludarabine, Cyclophosphamide, and others.
• CAR-T Therapeutic Assessment by Product Type: Mono, Combination, Mono/Combination
• CAR-T Therapeutic Assessment by Clinical Stages: Discovery, Pre-clinical, Phase I, Phase II, Phase III

For a detailed overview of our latest research findings and future plans, read the full details of CAR-T Pipeline on our website @ CAR-T Emerging Drugs and Companies- https://www.delveinsight.com/sample-request/car-t-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=ypr

Table of Content
1. Introduction
2. Executive Summary
3. CAR-T: Overview
4. Pipeline Therapeutics
5. Therapeutic Assessment
6. CAR-T- DelveInsight's Analytical Perspective
7. Late Stage Products (Phase III)
8. Drug name: Company name
9. Drug profiles in the detailed report…..
10. Mid Stage Products (Phase II)
11. Descartes-08: Cartesian Therapeutics
12. Drug profiles in the detailed report…..
13. Early Stage Products (Phase I)
14. ATA3219: Atara Biotherapeutics
15. Drug profiles in the detailed report…..
16. Preclinical and Discovery Stage Products
17. Drug name: Company name
18. Drug profiles in the detailed report…..
19. Inactive Products
20. CAR-T Key Companies
21. CAR-T Key Products
22. CAR-T- Unmet Needs
23. CAR-T- Market Drivers and Barriers
24. CAR-T- Future Perspectives and Conclusion
25. CAR-T Analyst Views
26. CAR-T Key Companies
27. Appendix

List of the Top Selling Market Research Reports in 2024

Celiac Disease Market: https://www.delveinsight.com/report-store/celiac-disease-cd-market
Coronary Stents Market: https://www.delveinsight.com/report-store/coronary-stents-market-market
CXCR Inhibitors Market: https://www.delveinsight.com/report-store/selective-inhibitor-of-the-cxcr4-chemokine-receptor-market-forecast
Diabetic Gastroparesis Market: https://www.delveinsight.com/report-store/gastroparesis-market
Fertility Monitoring Devices Market: https://www.delveinsight.com/report-store/fertility-monitoring-devices-fertility-testing-devices-market
Phototherapies for Psoriasis Market: https://www.delveinsight.com/report-store/phototherapies-for-psoriasis-market
Pipeline Assessment Services: https://www.delveinsight.com/consulting/pipeline-assessment-services
Ranibizumab Biosimilars Market: https://www.delveinsight.com/report-store/ranibizumab-biosimilars-insight
Rhinitis Market: https://www.delveinsight.com/report-store/rhinitis-market
Skin Grafting Devices Market: https://www.delveinsight.com/report-store/skin-grafting-devices-market
Spinal Implants Market: https://www.delveinsight.com/report-store/spinal-implants-market
Surgical Sealant Market: https://www.delveinsight.com/report-store/surgical-sealant-and-adhesives-market
Thrombectomy Devices Market: https://www.delveinsight.com/report-store/thrombectomy-devices-market
Venous Ulcer Market: https://www.delveinsight.com/report-store/venous-leg-ulcer-market
ADHD Market: https://www.delveinsight.com/report-store/attention-deficit-hyperactivity-disorder-adhd-market
Bacterial Meningitis Market: https://www.delveinsight.com/report-store/meningococcal-meningitis-market
Heart Pump Devices Market: https://www.delveinsight.com/report-store/heart-pump-device-market
Meningococcal Meningitis Market: https://www.delveinsight.com/report-store/meningococcal-meningitis-market
Percutaneous Arterial Closure Device Market: https://www.delveinsight.com/report-store/vascular-closure-devices-market
Pouchitis Market: https://www.delveinsight.com/report-store/pouchitis-market
Respiratory Syncytial Virus Market: https://www.delveinsight.com/report-store/respiratory-syncytial-virus-rsv-market
Shingles Market: https://www.delveinsight.com/report-store/shingles-market
Artificial Disc Market: https://www.delveinsight.com/report-store/artificial-disc-market
Avascular Necrosis Market: https://www.delveinsight.com/report-store/avascular-necrosis-market
Embolotherapy Market: https://www.delveinsight.com/report-store/embolotherapy-market
Orthopedic Power Devices Market: https://www.delveinsight.com/report-store/orthopedic-power-devices-market
Perennial Allergic Rhinitis Market: https://www.delveinsight.com/report-store/allergic-rhinitis-market
Plaque Psoriasis Market: https://www.delveinsight.com/report-store/plaque-psoriasis-market
Psoriasis Vulgaris Market: https://www.delveinsight.com/report-store/psoriasis-vulgaris-market
Transcatheter Heart Valve Replacement Devices Market: https://www.delveinsight.com/report-store/transcatheter-aortic-valve-replacement-market
UK Healthcare Report: https://www.delveinsight.com/report-store/uk-healthcare-outlook-report
Attention Deficit Hyperactivity Disorder Market: https://www.delveinsight.com/report-store/attention-deficit-hyperactivity-disorder-adhd-market
Brucellosis Market: https://www.delveinsight.com/report-store/brucellosis-market
Coronary Angioplasty Market: https://www.delveinsight.com/report-store/coronary-stents-market-market
NK Cell Therapy Market: https://www.delveinsight.com/report-store/nk-cell-therapy-market
Scoliosis Market: https://www.delveinsight.com/report-store/scoliosis-market
Surgical Site Infections Market: https://www.delveinsight.com/report-store/surgical-site-infections-ssi-market
Attention Deficit Hyperactivity Disorder ADHD Market: https://www.delveinsight.com/report-store/attention-deficit-hyperactivity-disorder-adhd-market
Catheter Stabilization Devices Market: https://www.delveinsight.com/report-store/catheter-stabilization-securement-device-market
Diabetic Wound Market: https://www.delveinsight.com/report-store/diabetic-foot-ulcers-dfus-market
Dyspepsia Market: https://www.delveinsight.com/report-store/functional-dyspepsia-market-share
Indwelling Catheters Market: https://www.delveinsight.com/report-store/indwelling-catheters-market
Orthopedic Splints Device Market: https://www.delveinsight.com/report-store/orthopedic-splints-market
Sepsis Market: https://www.delveinsight.com/report-store/sepsis-market
Overactive Bladder Syndrome Market: https://www.delveinsight.com/report-store/overactive-bladder-market
Spinal Trauma Devices Market: https://www.delveinsight.com/report-store/spinal-trauma-devices-market-market
Temporomandibular Disorders Market: https://www.delveinsight.com/report-store/temporomandibular-disorders-market
Viscosupplementation Devices Market: https://www.delveinsight.com/report-store/viscosupplementation-devices-market
Vitreoretinal Surgery Devices Market: https://www.delveinsight.com/report-store/vitreoretinal-surgery-devices-market
Advanced Liver Cancer Market: https://www.delveinsight.com/report-store/liver-cancer-market
Gene Therapy in CNS Disorder Market: https://www.delveinsight.com/report-store/gene-therapy-in-cns-disorder-market
Lice Infestations Market: https://www.delveinsight.com/report-store/lice-infestations-market
Plantar Fasciitis Market: https://www.delveinsight.com/report-store/plantar-fasciitis-market
Biopsy Devices Market: https://www.delveinsight.com/report-store/biopsy-devices-market
Endoscopic Ultrasound Market: https://www.delveinsight.com/report-store/endoscopic-ultrasound-market
Healthcare Consulting Solutions: https://www.delveinsight.com/consulting
Pelvic Organ Prolapse Market: https://www.delveinsight.com/report-store/pelvic-organ-prolapse-market
Pulmonary Emphysema Market: https://www.delveinsight.com/report-store/chronic-obstructive-pulmonary-disease-copd-market
Schistosomiasis Market: https://www.delveinsight.com/report-store/schistosomiasis-market
Testicular Neoplasm Market: https://www.delveinsight.com/report-store/testicular-neoplasm-market
Tourette Syndrome Market: https://www.delveinsight.com/report-store/tourette-syndrome-market
Wound Healing Devices Market: https://www.delveinsight.com/report-store/wound-healing-devices-market
Chronic Neuropathic Pain Market: https://www.delveinsight.com/report-store/chronic-neuropathic-pain-market
Fabry Disease Market: https://www.delveinsight.com/report-store/fabry-disease-market
Transcatheter Treatment Market: https://www.delveinsight.com/report-store/transcatheter-treatment-market
SGLT2 Inhibitors Market: https://www.delveinsight.com/report-store/sglt2-inhibitors-market
Surgical Lasers Market: https://www.delveinsight.com/report-store/surgical-lasers-market
Stem Cell Market: https://www.delveinsight.com/report-store/stem-cell-market
Myeloproliferative Neoplasms Market: https://www.delveinsight.com/report-store/myeloproliferative-neoplasms-market
Pacemakers Market: https://www.delveinsight.com/report-store/pacemakers-market
Urea Cycle Disorders Market: https://www.delveinsight.com/blog/urea-cycle-disorder-market
Varicose Vein Treatment Devices Market: https://www.delveinsight.com/report-store/varicose-vein-treatment-devices-market
Bone Growth Stimulator Market: https://www.delveinsight.com/report-store/bone-growth-stimulators-market
Intraocular Lens Market: https://www.delveinsight.com/blog/top-companies-in-the-intraocular-lens-market
Lymphoedema Market: https://www.delveinsight.com/report-store/lymphedema-market
Somatotropin Deficiency Market: https://www.delveinsight.com/report-store/somatotropin-deficiency-market
Skin Neoplasm Market: https://www.delveinsight.com/report-store/nonmelanoma-skin-cancer-market
Antibody Drug Conjugate Market: https://www.delveinsight.com/report-store/antibody-drug-conjugate-market
Healthcare Competitive Benchmarking: https://www.delveinsight.com/consulting/competitive-benchmarking-services
Surgical Mask & Respirator Market: https://www.delveinsight.com/report-store/surgical-mask-respirator-market
Meibomian Gland Dysfunction Market: https://www.delveinsight.com/report-store/meibomian-gland-dysfunction-pipeline-insight
Novel Drug Delivery Devices Market: https://www.delveinsight.com/report-store/novel-drug-delivery-devices
Total Knee Arthroplasty Market: https://www.delveinsight.com/report-store/total-knee-arthroplasty-market
Asperger Syndrome Market: https://www.delveinsight.com/report-store/autism-spectrum-disorder-asd-market
Medical Marijuana Market: https://www.delveinsight.com/report-store/medical-marijuana-market-insight
Lactose Intolerance Market: https://www.delveinsight.com/report-store/lactose-intolerance-market
Microscopy Device Market: https://www.delveinsight.com/sample-request/microscopy-device-market

About Us

DelveInsight is a leading healthcare-focused market research and consulting firm that provides clients with high-quality market intelligence and analysis to support informed business decisions. With a team of experienced industry experts and a deep understanding of the life sciences and healthcare sectors, we offer customized research solutions and insights to clients across the globe. Connect with us to get high-quality, accurate, and real-time intelligence to stay ahead of the growth curve.

Company Name: DelveInsight Business Research LLP
Contact Person: Yash Bhardwaj
Email: info@delveinsight.com
Phone: 09650213330
Address: 304 S. Jones Blvd #2432
City: Las Vegas
State: NV
Country: United States
Website: https://www.delveinsight.com/

This release was published on openPR.