Oligonucleotide Synthesis, Modification, and Purification Services Market Robust Expansion is expected to 2031

Oligonucleotide Synthesis, Modification, and Purification Services Market worth $7.83 Billion by 2031 - Exclusive Report by InsightAce Analytic

InsightAce Analytic Pvt. Ltd. announces the release of a market assessment report on the " Global Oligonucleotide Synthesis, Modification and Purification Services Market Oligonucleotide Mfg. Type (Antisense Oligonucleotides, siRNA, miRNA, And Other Oligonucleotides), Applications (Research And Diagnostic, Therapeutic, And Contract Manufacturing (OEM)), Operation Scale (Large-Scale Oligonucleotide Synthesis, Intermediate-Scale Oligonucleotide Synthesis, And Small-Scale Oligonucleotide Synthesis), Therapeutic Areas (Oncological Disorders, Eye Disorders, Metabolic Disorders, Autoimmune Disorders, And Other Therapeutic Areas), End-users (Pharmaceutical & Biotechnology Companies, Hospitals & Diagnostic Laboratories, Contract Research Organizations (Cros) And Contract Manufacturing Organizations (Cmos), And Academic Research Institutes) - Trends, Industry Competition Analysis, Revenue, and Forecast till 2030."

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According to InsightAce Analytic's most recent research, the global oligonucleotide synthesis, modification, and purification services market was valued at 1.77 billion in 2022 and is expected to reach 7.83 billion by 2031, growing at an 18.08% CAGR during the forecast period of 2023-2031.

Major market players operating in the oligonucleotide synthesis, modification, and purification services market include Ajinomoto Bio-Pharma Services, Integrated DNA Technologies, Kaneka Eurogentec, LGC Biosearch Technologies, Microsynth, MilliporeSigma, BioSpring, CordenPharma, Nitto Denko Avecia, TriLink Biotechnologies, Eurofins Scientific SE, Thermo Fisher Scientific Inc., Agilent Technologies, Inc., GE Healthcare, GeneDesign, Inc., Bio-synthesis Inc., ATDBio Ltd, Burkert UK Limited, Almac Group, and Other Prominent Players.

Modified oligoribonucleotides have recently become increasingly popular in molecular biology, biochemistry, and medicine. Oligonucleotides are defined as short, single-stranded DNA or RNA molecules. Solid-phase synthesis produces synthetic DNA or RNA oligonucleotides, which are used in a variety of molecular biology applications including PCR, real-time PCR, sequencing, site-directed mutagenesis, single nucleotide polymorphism (SNP) assays, microarrays, and therapeutic applications. For many years, chemically modified oligonucleotides have been extensively studied in order to develop new antisense and siRNA treatments. Companies want more robust and dependable methods for characterizing and monitoring oligonucleotide and mRNA products in order to produce novel vaccines and pharmaceutical goods on schedule.
Factors such as the increasing need for custom, high-quality oligos for NGS applications, advancement in the synthesis and purification technologies, rising product launches by market players, high prevalence of chronic and genetic disorders, increasing geriatric population, rising custom oligo synthesis services, rising R&D activities in biotechnology companies to improve oligo synthesis and purification processes, and increasing demand for personalized medicines are Furthermore, market players' expansion of production facilities, as well as initiatives such as collaborations, mergers, and agreements, are expected to boost market growth in the near future. For example, in February 2018, STA Pharmaceutical Co. (China), a WuXi AppTec group firm, and Regulus Therapeutics (US) signed an oligonucleotide synthesis collaboration agreement for research and mid-scale non-GMP/cGMP production. In June 2017, CordenPharma International announced a collaboration with GE Healthcare's Dharmacon division to create an end-to-end solution for oligonucleotide-based drug discovery.
However, the high costs associated with the purification process, complex manufacturing techniques, oligo-degradation in generic research, and in-house oligonucleotide creation may impede the growth of the global oligonucleotide synthesis, modification, and purification services market.

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Geographically, North America is expected to hold the largest share of this market in the coming years, followed by Europe. Europe is predicted to have significant growth in this market as a result of improved healthcare infrastructure and increased use of oligonucleotides to develop novel medicinal therapies.

Key Developments In The Market:
• In Oct 2021, TriLink BioTechnologies stated that it plans to provide EyeGene, Inc. with its CleanCap® mRNA capping process and the modified nucleoside, uridine triphosphate, for the manufacturing of EyeGene's mRNA COVID-19 vaccine. This cooperation with EyeGene is anticipated to be the first clinical-stage initiative to utilise TriLink's GMP-grade modified uridine triphosphate designed for further processing.
• In June 2021, Thermo Fisher Scientific teamed up to build end-to-end procedures for complicated oligonucleotide and mRNA products. This collaboration combines the University of Sheffield's research expertise with Thermo Fisher's sample preparation, liquid chromatography (LC), high-resolution accurate-mass (HRAM), mass spectrometry (MS), and data interpretation software technologies to develop streamlined analytical workflows and robust fit-for-purpose processes.
• In January 2021, MilliporeSigma (US) acquired AmpTec, a leading Germany-based mRNA contract development and manufacturing organization (CDMO). The deal strengthens MilliporeSigma's capabilities to develop and manufacture mRNA for its customers for use in vaccines, treatments, and diagnostics applicable in Covid-19 and many other diseases.
• In September 2019, GeneDesign (Japan) acquired Ajinomoto Bio-Pharma Services, becoming part of the contract development and manufacturing organization (CDMO). The integration of GeneDesign's services offerings with Aji Bio-Pharma's small and large molecule capabilities in the U.S., Belgium, and India strengthens the CDMO's capabilities.
• In 2019, Integrated DNA Technology (US) launched 'oPools- oligo pools', a pool of high-quality DNA oligonucleotides with 350 nucleotides in length.

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Market Segments
Oligonucleotide Synthesis, Modification, and Purification Services Market, by By Oligonucleotide mfg. Types, 2022-2030 (Value US$ Bn)
• Antisense Oligonucleotides
• siRNA
• shRNA
• miRNA
• Aptamers
• Primers
• Probes
• Others (Adapters for NSG)

Oligonucleotide Synthesis, Modification, and Purification Services Market, by Applications, 2022-2030 (Value US$ Bn)
• Research and Diagnostic
o PCR
o qPCR/RTqPCR
o Sequencing
o Gene Synthesis
o Other Research Applications
• Therapeutic
o RNAi Oligonucleotide-based Therapies
o DNA/Antisense oligonucleotide-based Therapies
o Immunotherapy (CpG Oligonucleotide-based Therapies)
o Nucleic Acid Aptamer
• Contract Manufacturing

Oligonucleotide Synthesis, Modification, and Purification Services Market, by Operation Scale, 2022-2030 (Value US$ Bn)
• Large-Scale Oligonucleotide Synthesis
• Intermediate-Scale Oligonucleotide Synthesis
• Small-Scale Oligonucleotide Synthesis
Oligonucleotide Synthesis, Modification, and Purification Services Market, by Therapeutic Areas, 2022-2030 (Value US$ Bn)
• Oncological Disorders
• Eye Disorders
• Metabolic Disorders
• Autoimmune Disorders
• Other Therapeutic Areas
Oligonucleotide Synthesis, Modification, and Purification Services Market, by End-Users, 2022-2030 (Value US$ Bn)
• Pharmaceutical & Biotechnology Companies
• Hospitals & Diagnostic Laboratories
• Contract research organisations (CROs) and contract manufacturing organisations (CMOs)
• Academic Research Institutes
Oligonucleotide Synthesis, Modification, and Purification Services Market, by Region, 2022-2030 (Value US$ Bn)
• North America
• Europe
• Asia Pacific
• Latin America
• Middle East & Africa
North America Oligonucleotide Synthesis, Modification, and Purification Services Market, by Country, 2022-2030 (Value US$ Bn)
• U.S.
• Canada
Europe Oligonucleotide Synthesis, Modification, and Purification Services Market, by Country, 2022-2030 (Value US$ Bn)
• Germany
• France
• Italy
• Spain
• Russia
• Rest of Europe
Asia Pacific Oligonucleotide Synthesis, Modification, and Purification Services Market, by Country, 2022-2030 (Value US$ Bn)
• India
• China
• Japan
• South Korea
• Australia & New Zealand
Latin America Oligonucleotide Synthesis, Modification, and Purification Services Market, by Country, 2022-2030 (Value US$ Bn)
• Brazil
• Mexico
• Rest of Latin America
Middle East & Africa Oligonucleotide Synthesis, Modification, and Purification Services Market, by Country, 2022-2030 (Value US$ Bn)
• GCC Countries
• South Africa
• Rest of Middle East & Africa

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