Press release
ProBio offers ADCC assay (SC1544) and CDC assay (SC1545) services for customers
Endpoint-Based, and Speedy
Dramatic improvement of ADCC [https://www.probiocdmo.com/add-adcc-cdc-assay.html] by using recombinant NK cells
Antibody therapy has been proven to be highly powerful for cancer treatment. Two important mechanisms used by antibody drugs to kill targeted tumor cells are Antibody-Dependent Cell-Mediated Cytotoxicity (ADCC), and Complement Dependent Cytotoxicity (CDC). ProBio is pleased to present to customers both a PBMC-based ADCC assay [https://www.probiocdmo.com/add-adcc-cdc-assay.html] and natural kill cell-based ADCC assay. The readout is endpoint-driven (target cell lysis). The CDC assay [https://www.probiocdmo.com/add-adcc-cdc-assay.html] uses normal human serum as the source of complement. By implementing strict QC standards, ProBio can provide the assurance of the efficacy and potency profiles of the therapeutic antibodies.
ADCC mechanism
Image: https://www.probiocdmo.com/img/gsprobio/addc-mechanism.jpg
ADCC Case Study
Image: https://www.probiocdmo.com/img/gsprobio/addc-1.jpg
Figure 1 Concentration-dependent study of Herceptin-mediated ADCC on SK-BR-3 cells by using PBMC as effector cells (human IgG as negative control)
Image: https://www.probiocdmo.com/img/gsprobio/addc-2.jpg?v=1
Figure 2 Concentration-dependent study of Erbitux-mediated ADCC on A431 cells by using freshly isolated NK cells as effector cells (Rituxan as negative control)
Image: https://www.probiocdmo.com/img/gsprobio/addc-3.jpg
Figure 3 Concentration-dependent study of Humira-mediated ADCC on CHO/tm TNF- cells by using PBMC as effector cells (human IgG as negative control). CHO/tm TNF- was a cell line stably expressed membrane bound TNF- at which the proteolytic cleavage site was modified.
CDC Mechanism
Image: https://www.probiocdmo.com/img/gsprobio/20141009102428.png
Case Study 1: Rituxan elicited CDC lysis of two CD20-positive leukemia cell lines
Image: https://www.probiocdmo.com/img/gsprobio/adcc20131112154716.jpg
Image: https://www.probiocdmo.com/img/gsprobio/adcc20131112154732.jpg
NHS: normal human serum
Key features of ProBio's ADCC & CDC assay services [https://www.probiocdmo.com/add-adcc-cdc-assay.html]
* Data readout is driven by the target cell lysis endpoint
* High throughput assay service for bulk antibody drug screening
* Large panel of target tumor cell lines free of charge to be used in ADCC assays
* Ready-to-go ADCC assay format for at least 4 targets, HER2/ErbB2, CD20, EGFR, and TNF
* Ready-to-go CDC assay format for at least 2 targets, CD20 and TNF
Media Contact
Company Name: ProBio CDMO
Email: Send Email [http://www.universalpressrelease.com/?pr=probio-offers-adcc-assay-sc1544-and-cdc-assay-sc1545-services-for-customers]
Phone: 1-877-436-7274 (Toll-Free)
Country: United States
Website: https://www.probiocdmo.com
This release was published on openPR.
Permanent link to this press release:
Copy
Please set a link in the press area of your homepage to this press release on openPR. openPR disclaims liability for any content contained in this release.
You can edit or delete your press release ProBio offers ADCC assay (SC1544) and CDC assay (SC1545) services for customers here
News-ID: 3761908 • Views: …
More Releases from Getnews
Chaz Edward Local Marketing Unveils Game-Changing "Social Media Map Stacking" St …
Image: https://www.globalnewslines.com/uploads/2025/09/1757328787.jpg
York, Pennsylvania - September 8, 2025 - Chaz Edward Local Marketing today unveiled a bold new approach to local search optimization: the Maps Social Media [https://chazedward.com/local-social-media-marketing/] service.
Built on the strategic integration of Google Business Profile (GBP), social media, content, and advanced SEO tactics, this innovative offering is already delivering remarkable results across diverse industries. Watch how it works:
Video: https://www.youtube.com/embed/azKDxTwQWXs
Key Outcomes from Recent Campaigns
*
Rapid Google Maps domination: Businesses achieved…
Readers' Favorite recognizes "To Kill a Cockroach" by Osvaldo Calixto Amador in …
Image: https://www.globalnewslines.com/uploads/2025/09/1757348419.jpg
Readers' Favorite recognizes "To Kill a Cockroach" by Osvaldo Calixto Amador in its annual international book award contest, currently available at http://www.amazon.com/gp/product/0615675794.
The Readers' Favorite International Book Award Contest featured thousands of contestants from over a dozen countries, ranging from new independent authors to NYT best-sellers and celebrities.
Image: https://m.media-amazon.com/images/I/31PAgC-OJLL._SL400_.jpg
Readers' Favorite is one of the largest book review and award contest sites on the Internet. They have earned the respect of…
Readers' Favorite recognizes "Predestined" by Rachel Byrne in its annual interna …
Image: https://www.globalnewslines.com/uploads/2025/09/1757348267.jpg
Readers' Favorite recognizes "Predestined" by Rachel Byrne in its annual international book award contest, currently available at http://www.amazon.com/gp/product/B0DFN1GGZV.
The Readers' Favorite International Book Award Contest featured thousands of contestants from over a dozen countries, ranging from new independent authors to NYT best-sellers and celebrities.
Image: https://m.media-amazon.com/images/I/51IsaRu4R0L._SL400_.jpg
Readers' Favorite is one of the largest book review and award contest sites on the Internet. They have earned the respect of renowned publishers like Random…
Author's new book "A Tree with My Name on It" receives a warm literary welcome
Image: https://www.globalnewslines.com/uploads/2025/09/1757348147.jpg
Readers' Favorite announces the review of the Non-Fiction - Memoir book "A Tree with My Name on It" by Victress Hitchcock, currently available at http://www.amazon.com/gp/product/195480590X.
Readers' Favorite is one of the largest book review and award contest sites on the Internet. They have earned the respect of renowned publishers like Random House, Simon & Schuster, and Harper Collins, and have received the "Best Websites for Authors" and "Honoring Excellence" awards…
More Releases for ADCC
Creative Biolabs Advances Antibody Research With Integrated ADCC and ADCP Functi …
Creative Biolabs today announced commercially available, fully integrated ADCC and ADCP that assess how an antibody engages immune mechanisms and thus guide the rational design of candidate therapeutic antibodies.
New York, USA - August 20, 2025 - During the antibody development timeline, understanding functional efficacy remains an indispensable milestone for characterizing therapeutic promise. Antibody performance, whether in oncology or autoimmunity, ultimately hinges on which in vivo signals become amplified. The most…
ProBio is now licensing the CHOK1 cell line development system to biopharma comp …
CHOK1-GenS&CHOK1-ADCC+
Cell Line Development System Commercial License
ProBio has 12 years of experience in mammalian cell line development [https://www.probiocdmo.com/add-host-cell-license.html], and is one of the earliest companies getting the CHO-K1 - CHO commercial license for commercial use and sublicense agreement from ECACC.
ProBio has two cell line development systems [https://www.probiocdmo.com/add-host-cell-license.html]: wild-type cell line CHOK1-GenS and ADCC-enhanced cell line CHOK1-ADCC +. CHOK1-GenS cell line development system without chemical . Developed ADCC enhanced host cell line…
ProBio provides top-quality cell line development services for a variety of ther …
ProCLD Cell Line Development Services
10 Weeks from DNA to Top 6 Clones
ProBio provides top-quality cell line development services [https://www.probiocdmo.com/add-procld-cell-line-development-services.html] for a variety of therapeutic biologics utilizing our cell line technology ecosystem. With an industry-leading timeline and high productivity deliverables, ProBio saves time and money for the clients from the vey beginning.
ProBio specializes in the cell line development [https://www.probiocdmo.com/add-procld-cell-line-development-services.html] of complex molecules. ProBio has accumulated extensive experience in developing bispecific antibodies…
Mechanisms and Efficacy of Claudin 18.2 Antibodies
The development and implementation of Claudin 18.2 antibodies in cancer therapy have introduced new mechanisms and demonstrated significant efficacy. Claudin 18.2, a tight junction protein, is overexpressed in several cancers, making it an ideal target for precision oncology. This article explores the mechanisms through which Claudin 18.2 antibodies operate and their efficacy in treating cancer.
Download Report:
https://www.kuickresearch.com/report-caludin-18-2-cldn-18-2-target-protein-cancer-antibodies-cldn-immmunotherapy-claudin-expression-targeting-claudin
Claudin 18.2 is selectively expressed in cancers such as gastric, pancreatic, and ovarian cancers,…
Creative Biolabs: Therapeutic Antibody Engineering Unlocks New Avenues in Target …
Recent research by the team at Creative Biolabs has led to the development of a platform that integrates a series of innovative therapeutic antibody engineering technologies.
New York, USA - May 27, 2024 - Therapeutic antibody engineering [https://adcc.creative-biolabs.com/therapeutic-antibody-engineering-services.htm] is becoming a crucial area in therapy development for diseases such as cancer, infectious diseases, and autoimmune disorders. This field provides scientists with new methods for targeting and killing cells.
Image: https://www.getnews.info/uploads/0c59d26f78bf6dd58aafee5bc68d7d8c.jpg
"Antibody-dependent cell-mediated cytotoxicity…
Global Biosimilar Testing and Development Services Market Report Overview 2019-2 …
Market Research Hub (MRH) has actively included a new research study titled “Global Biosimilar Testing and Development Services Market Size, Status and Forecast 2019-2025” to its wide online repository. The concerned market is discoursed based on a variety of market influential factors such as drivers, opportunities and restraints. This study tends to inform the readers about the current as well as future market scenarios extending up to the period until…
