Cushing's Syndrome Market to Show a Rise During the Study Period | Corcept Therapeutics Inc., Recordati SpA, Laboratorie HRA Pharma SAS, Strongbridge Biopharma PLC., Sparrow Pharmaceuticals, and others

DelveInsight's "Cushing's Syndrome Market Insights, Epidemiology, and Market Forecast-2032" report delivers an in-depth understanding of the Cushing's Syndrome, historical and forecasted epidemiology as well as the Cushing's Syndrome market trends in the United States, EU5 (Germany, Spain, Italy, France, and United Kingdom) and Japan.

The Cushing's Syndrome market report provides current treatment practices, emerging drugs, Cushing's Syndrome market share of the individual therapies, and current and forecasted Cushing's Syndrome market size from 2019 to 2032 segmented by seven major markets. The Report also covers current Cushing's Syndrome treatment practice/algorithm, market drivers, market barriers, and unmet medical needs to curate the best of the opportunities and assesses the underlying potential of the Cushing's Syndrome market.

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Recent breakthroughs in the cushing's syndrome market:

FDA Approval: The U.S. Food and Drug Administration (FDA) approved Isturisa (osilodrostat) oral tablets for adults with Cushing's disease who either cannot undergo pituitary gland surgery or have undergone the surgery but still have the disease.
Pipeline Advances: The Cushing syndrome pipeline includes promising drugs like Relacorilant (Corcept Therapeutics), and CRN-04894 (Crinetics Pharmaceuticals), expected to be launched in the next decade.

Key highlights from the cushing's syndrome market report:

The Cushing's syndrome market is expected to see significant growth in the coming years, driven by the anticipated launch of promising therapies from leading companies such as Corcept Therapeutics, Crinetics Pharmaceuticals, Cyclacel Pharmaceuticals, Sparrow Pharmaceuticals, Stero Therapeutics, and others. These companies are advancing various drug candidates through different stages of development. With the expected approval of these therapies during the forecast period (2023-2032), the overall therapeutic market for Cushing's syndrome is projected to experience a substantial compound annual growth rate (CAGR).

Key factors driving this growth include the introduction of innovative treatments and diagnostic solutions in the seven major markets. The emergence of novel therapies based on new mechanisms, such as HSD-1 inhibitors and ACTH antagonists, is expected to boost the market while potentially reducing the market share of older steroidogenesis inhibitors, which are less effective and often associated with undesirable side effects.

The COVID-19 pandemic has had an impact on the Cushing's syndrome market by causing disruptions in non-urgent medical services, including diagnostic tests and procedures. This led to delays in diagnosis and treatment initiation, which in turn affected the overall market for Cushing's syndrome.

According to DelveInsight's analysts, the incidence of Cushing's syndrome has been increasing in recent years. However, with limited late-stage pipeline products, companies may focus on developing innovative therapies that target treatment endpoints beyond just lowering cortisol levels, potentially paving the way for more effective and comprehensive management of the condition.

Cushing's Syndrome Overview

Cushing's syndrome, also known as hypercortisolism, is a condition caused by prolonged exposure to high levels of cortisol, a hormone produced by the adrenal glands. This excessive cortisol can result from various factors, such as the use of corticosteroid medications or the presence of tumors that produce cortisol. Below is an overview of the syndrome, including its causes, symptoms, diagnosis, and treatment options:

Causes of Cushing's Syndrome:

- Exogenous Cushing's Syndrome: This form occurs when individuals take corticosteroid medications for extended periods. These drugs may be prescribed to treat conditions like asthma, rheumatoid arthritis, or lupus.

- Endogenous Cushing's Syndrome: This occurs when the body produces too much cortisol on its own. Potential causes include:
- Pituitary Adenoma (Cushing's Disease): A noncancerous tumor in the pituitary gland that secretes excessive adrenocorticotropic hormone (ACTH), which stimulates the adrenal glands to produce more cortisol.
- Adrenal Tumors: Both benign and malignant tumors in the adrenal glands can lead to excessive cortisol production.
- Ectopic ACTH Syndrome: Certain tumors outside the pituitary or adrenal glands can also produce ACTH, leading to increased cortisol production.

Signs and Symptoms of Cushing's Syndrome:

- Weight Gain: Particularly in the face (often referred to as "moon face"), upper back, and abdomen (central obesity).
- Thin, Fragile Skin: Skin that bruises easily and may have purple stretch marks (striae).
- Muscle Weakness: Especially in the muscles closest to the body (proximal muscles), such as those in the upper arms and thighs.
- Hypertension: High blood pressure.
- Elevated Blood Sugar: This can lead to the development of diabetes or worsen pre-existing diabetes.
- Menstrual Irregularities: Women may experience irregular periods.
- Fatigue and Weakness: Persistent tiredness or weakness.
- Mood Changes: Irritability, mood swings, anxiety, or depression.
- Osteoporosis: Bone loss leading to brittle bones and increased fracture risk.

Diagnosis of Cushing's Syndrome:

- Medical History and Physical Examination: A doctor will begin by reviewing the patient's symptoms and performing a physical exam to identify characteristic signs of Cushing's syndrome.
- Blood Tests: These tests measure cortisol levels and may also include an evaluation of ACTH levels.
- Urine Tests: A 24-hour urine collection can be used to measure cortisol output over a full day.
- Imaging Tests: MRI or CT scans can help locate tumors in the pituitary or adrenal glands.
- Dexamethasone Suppression Test: This test involves taking a dose of dexamethasone (a synthetic steroid) and measuring how cortisol levels respond to it. In Cushing's syndrome, cortisol levels typically remain high despite the suppression test.

Treatment Options for Cushing's Syndrome:

- Surgery: The primary treatment is often surgical removal of the tumor causing excessive cortisol production. This may involve:
- Pituitary Surgery (Transsphenoidal Surgery): For tumors in the pituitary gland.
- Adrenal Surgery (Adrenalectomy): For tumors in the adrenal glands.

- Radiation Therapy: This is used if surgery is not successful, or if the tumor cannot be completely removed. Radiation therapy is usually targeted at pituitary tumors.

- Medications: In some cases, medications may be used to help control cortisol levels or manage symptoms. These include:
- Metyrapone, or Mitotane-drugs that can decrease cortisol production.

- Lifestyle Modifications: These may help improve overall health and manage symptoms. A healthy diet, regular exercise, and stress management techniques are important components of treatment.

- Regular Monitoring: Patients with Cushing's syndrome often need ongoing monitoring to ensure that cortisol levels remain within a healthy range and to manage any complications or side effects of treatment.

Long-Term Management and Complications:
Cushing's syndrome requires careful, ongoing management. Long-term complications, such as osteoporosis, hypertension, and diabetes, must be addressed as part of the comprehensive treatment plan to improve quality of life and reduce the risk of further health issues. Regular follow-up with healthcare providers is essential to ensure that cortisol levels are controlled and to monitor for potential relapses or complications.

In summary, Cushing's syndrome is a complex condition that requires individualized treatment, often involving surgery, medication, and lifestyle changes. Early diagnosis and effective management are key to minimizing the long-term impact of the syndrome on overall health.

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Cushing's Syndrome Market

The Cushing's Syndrome market outlook of the report helps to build a detailed comprehension of the historic, current, and forecasted Cushing's Syndrome market trends by analyzing the impact of current Cushing's Syndrome therapies on the market, unmet needs, and drivers and barriers, and demand for better technology.

This segment gives a thorough detail of the Cushing's Syndrome market trend of each marketed drug and late-stage pipeline therapy by evaluating their impact based on the annual cost of therapy, inclusion and exclusion criteria, mechanism of action, compliance rate, growing need of the market, increasing patient pool, covered patient segment, expected launch year, competition with other therapies, brand value, their impact on the market and view of the key opinion leaders. The calculated Cushing's Syndrome market data are presented with relevant tables and graphs to give a clear view of the market at first sight.

According to DelveInsight, the Cushing's Syndrome market in 7MM is expected to witness a major change in the study period 2019-2032.

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Cushing's Syndrome Epidemiology

The Cushing's Syndrome epidemiology section provides insights into the historical and current Cushing's Syndrome patient pool and forecasted trends for individual seven major countries. It helps to recognize the causes of current and forecasted trends by exploring numerous studies and views of key opinion leaders. This part of the Cushing's Syndrome market report also provides the diagnosed patient pool and their trends along with assumptions undertaken.

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Cushing's Syndrome Drugs Uptake

This section focuses on the rate of uptake of the potential Cushing's Syndrome drugs recently launched in the Cushing's Syndrome market or expected to get launched in the market during the study period 2019-2032. The analysis covers Cushing's Syndrome market uptake by drugs; patient uptake by therapies; and sales of each drug.

Cushing's Syndrome Drugs Uptake helps in understanding the drugs with the most rapid uptake, and the reasons behind the maximal use of new drugs, and allows the comparison of the drugs on the basis of Cushing's Syndrome market share and size which again will be useful in investigating factors important in market uptake and in making financial and regulatory decisions.

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Cushing's Syndrome Therapeutics Assessment

Major pharma players such as Corcept Therapeutics Inc., Recordati SpA, Laboratorie HRA Pharma SAS, Strongbridge Biopharma PLC., Sparrow Pharmaceuticals, and others are working proactively in the Cushing's Syndrome therapeutics market to develop novel therapies which will drive the Cushing's Syndrome treatment market in the upcoming years.

Learn more about the emerging therapies & key companies at:
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Cushing's Syndrome Report Key Insights

1. Cushing's Syndrome Patient Population
2. Cushing's Syndrome Market Size and Trends
3. Key Cross Competition in the Cushing's Syndrome Market
4. Cushing's Syndrome Market Dynamics (Key Drivers and Barriers)
5. Cushing's Syndrome Market Opportunities
6. Cushing's Syndrome Therapeutic Approaches
7. Cushing's Syndrome Pipeline Analysis
8. Cushing's Syndrome Current Treatment Practices/Algorithm
9. Impact of Emerging Therapies on the Cushing's Syndrome Market

Table of Contents

1. Key Insights
2. Executive Summary
3. Cushing's Syndrome Competitive Intelligence Analysis
4. Cushing's Syndrome Market Overview at a Glance
5. Cushing's Syndrome Disease Background and Overview
6. Cushing's Syndrome Patient Journey
7. Cushing's Syndrome Epidemiology and Patient Population
8. Cushing's Syndrome Treatment Algorithm, Current Treatment, and Medical Practices
9. Cushing's Syndrome Unmet Needs
10. Key Endpoints of Cushing's Syndrome Treatment
11. Cushing's Syndrome Marketed Products
12. Cushing's Syndrome Emerging Therapies
13. Cushing's Syndrome Seven Major Market Analysis
14. Attribute Analysis
15. Cushing's Syndrome Market Outlook (7 major markets)
16. Cushing's Syndrome Access and Reimbursement Overview
17. KOL Views on the Cushing's Syndrome Market
18. Cushing's Syndrome Market Drivers
19. Cushing's Syndrome Market Barriers
20. Appendix
21. DelveInsight Capabilities
22. Disclaimer

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