Aurora Kinase Inhibitors Market Driven By Increasing Number Of Cancer Cases And Improving Healthcare Standard Outside The Developed World

The Aurora kinases are enzymes which are crucial for cell proliferation. These enzymes are responsible for dividing genetic material of the parent cell during the process of mitosis by controlling chromatid segregation. The defect related to this process is largely associated with cancer genesis in human body. In this way active involvement of aurora kinase enzymes in initiating cancer genesis has lead considerable attention of therapists to their inhibition in the work towards cancer treatment. There are three kind of aurora kinase found in human body namely A, B and C. Aurora C is mainly restricted to the process of spermatogenesis while remaining two are responsible various tumerogenesis. Though these are not restricted to particular cancer type but there are some examples of cancer in which over expression of specific aurora kinases has been observed. Amplified aurora A in lung, pancreatic, colon, cervical, prostrate, ovarian, brain and breast whereas aurora B in breast, colon, thyroid, oral and non small cell lung.

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Cancer is considered to the major causative factor for mortality worldwide with increasing incidence and prevalence day by day. All regions of the world have seen continuous rise in number of cancer patients in past decade. WHO predicted that annual cancer cases will reach to 19.3 million by 2025 from the 14.1 million annually in year 2012, whereas annual cases in 2008 were 12.7 million of which 1.7 million were women newly diagnosed with breast cancer that accounted for 20% in 2008. WHO mentions that cancer kills 8.2 millions globally out of which 522,000 woman from breast cancer. It is mentionable that incidence rate is still higher in developed region whereas death rates are higher in less developed countries. In all the cancer types, number of patients suffering with head and neck, gastrointestinal, breast and uterine cancer are highest.

Aurora family Kinase Assay/Inhibitor screening kits are designed to estimate the inhibitory effect of individual Aurora activity in the test chemical accurately. Merck Millipore, MBL International, Perkin Elmer, SignalChem are some of the leading companies which manufacture screening kits.

Geographically North American region accounts for the largest market share in this market which is followed by developing Asia Pacific market and European market. The market for Aurora Kinase inhibitor is driven by continuous increasing number of cancer cases and improving healthcare standard outside the developed world and advancements in early diagnosis of cancer. However there are restrictions such as high cost involved in drug development, lower spending capacity of poorer countries and need of real time clinical data. There are different kind of biological therapies in oncology such as Tyrosine kinase inhibitor (includes erlotinib, imatinib, gefitinib, dasatinib, sunitinib, ruxolitinib, etc.), monoclonal antibodies (includes trastuzumab, bevacizumab and cetuximab, etc.) whereas some are in development stage such as Aurora Kinase Inhibitor (Hesperadine, VX-680). Currently there is no molecule is approved in this market however there are almost 30 molecules of Aurora Kinase inhibitor class in development stage at different levels. With increase in cancer patients the market for Aurora Kinase Inhibitor market is set to increase.

Some of the major players in Aurora Kinase Inhibitor development market are Merck, Pfizer, Amgen, Millennium Pharmaceuticals, Cyclacel Pharmaceuticals, Bristol Myers Squibb. Along with these, there are companies such as Roche, Novartis, Eli Lilly, AstraZeneca, Celgene, Sanofi and GlaxoSmithKline have made their mark in oncology.

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