Congenital HyperInsulinism Market Size is Set for Rapid Growth as Innovative Treatments and Rising Awareness Drive Demand by 2034

The Congenital HyperInsulinism market size is expected to increase during the forecast period with the increasing prevalence, disease awareness, and promising emerging treatment options by leading companies such as XOMA (US) LLC, Hanmi Pharmaceutical Company Limited, Zealand Pharma, Xeris Pharmaceuticals, Assistance Publique, Filip Krag Knop, Tracey McLaughlin

[Nevada, United States] - DelveInsight's "Congenital HyperInsulinism Market Insights, Epidemiology, and Market Forecast 2034." report offers a detailed examination of Congenital HyperInsulinism, covering historical and predicted epidemiology, market trends, and treatment scenarios in the United States, EU4 (Germany, Spain, Italy, France), the United Kingdom, and Japan.

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Key Findings from the Congenital HyperInsulinism Market Report:
• The Congenital HyperInsulinism market size is poised for significant growth, with an anticipated Compound Annual Growth Rate (CAGR) during the study period (2020-2034).
• In August, 2024: Hanmi Pharmaceutical Company Limited announced that their study is designed to evaluate the safety, tolerability, pharmacokinetics (PK), and efficacy of HM15136 when used as add-on therapy in subjects with CHI with persistent hypoglycemia while on standard of care treatment (SoC). HM15136 will be administered once weekly in multiple doses to subjects in multiple age including pediatric to find appropriate exposure-response data.
• In April, 2024: Zealand Pharma announced an open-label, multinational, multicenter, long-term safety and efficacy extension trial in patients with Congenital Hyperinsulinism (CHI) who completed either ZP4207-17103 or ZP4207-17109 (defined as lead-in trials).
• As per the study by Yau et al. (2020), between 2007 to 2016, for England, Scotland, Wales and Northern Ireland, the minimum annual incidence of CHI in the UK was calculated as 1 in 28,389 live births.
• As per the study by Yamada et al. (2020) after excluding overlapping patients with the date of birth, sex and age at onset, 785 with endogenous hyperinsulinemic hypoglycemia (EHH) were finally identified. Of them, 447 had CHI (197 transient, 225 persistent and 25 unknown subtype).
• In the year 2022, the total diagnosed-prevalent cases of Congenital Hyperinsulinism were ~16,000 cases in the 7MM. In the 7MM, the highest number of diagnosed-prevalent cases of Congenital Hyperinsulinism were observed in the United States.
• Key Congenital HyperInsulinism Companies are as follows: XOMA (US) LLC, Hanmi Pharmaceutical Company Limited, Zealand Pharma, Xeris Pharmaceuticals, Assistance Publique, Filip Krag Knop, Tracey McLaughlin
• Key Congenital HyperInsulinism Therapies are as follow: Cohort, HM15136, dasiglucagon, Glucagon, Sandostatine, Dasiglucagon, Lyo avexitide, Liq avexitide
• Launching multiple stage Congenital HyperInsulinism pipeline products is expected to revolutionize market dynamics, further propelling market growth.

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Congenital HyperInsulinism Overview:
Congenital Hyperinsulinism (CHI) is a rare disease that causes due to abnormal insulin release. It is the most common cause of persistent hypoglycemia in infants and children and carries a considerable risk of neurological damage and developmental delays if delayed diagnosis and treatment

Congenital HyperInsulinism Epidemiology Segmentation:
The Congenital HyperInsulinism market report proffers epidemiological analysis for the study period 2020-2034 in the 7MM segmented into:
• Congenital HyperInsulinism Total Diagnosed Prevalent Cases
• Congenital HyperInsulinism Mutation-specific Diagnosed Cases
• Congenital HyperInsulinism Type-specific Diagnosed Prevalent Cases
• Congenital HyperInsulinism Total Treated Cases

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Congenital HyperInsulinism Market Insights
Congenital Hyperinsulinism (CHI) is a rare but severe genetic disorder characterized by excessive insulin production by the pancreas, leading to persistent hypoglycemia (low blood sugar). CHI typically manifests in neonates and infants, and if not managed promptly, it can result in developmental delays, neurological damage, or even life-threatening situations. The disorder is primarily caused by mutations in genes regulating insulin secretion, and its treatment aims to maintain normal blood glucose levels.

Congenital HyperInsulinism Drugs Uptake
• Diazoxide (marketed as Proglycem) is the most commonly used first-line treatment for CHI. It works by inhibiting insulin release from pancreatic beta cells. However, it is not effective in all forms of CHI, particularly those with mutations affecting KATP channels. Despite this, diazoxide remains a mainstay of CHI management.
• Octreotide, a somatostatin analog, is often used in patients who do not respond to diazoxide. It helps by inhibiting insulin secretion and is administered via subcutaneous injections.
• Sirolimus, an mTOR inhibitor, has shown efficacy in some forms of CHI, particularly in cases where other treatments fail. It is gaining attention as a potential therapy for severe, diazoxide-resistant forms of the disease.
• GLP-1 receptor antagonists represent a novel class of drugs that may inhibit insulin secretion. They are in the early stages of clinical development and hold promise for patients who are not responsive to traditional treatments.

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Congenital HyperInsulinism Therapies and Key Companies:
• Cohort: XOMA (US) LLC
• HM15136: Hanmi Pharmaceutical Company Limited
• dasiglucagon: Zealand Pharma
• Glucagon: Xeris Pharmaceuticals
• Sandostatine: Assistance Publique
• Dasiglucagon: Filip Krag Knop
• Lyo avexitide, Liq avexitide: Tracey McLaughlin

Congenital HyperInsulinism Epidemiology:
The epidemiology section provides insights into historical, current, and forecasted trends in the seven major countries (7MM) from 2020 to 2034. It explores various studies and opinions to recognize the causes of current and forecasted trends. The segmentation includes total prevalence, severity-based prevalence, gender-specific prevalence, and diagnosed cases of episodic and chronic Congenital HyperInsulinism.

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Congenital HyperInsulinism Market Drivers:
• Growing Awareness and Early Diagnosis
• Advances in Genetic Research
• Development of Novel Therapeutics
• Emerging Markets and Healthcare Accessibility

Congenital HyperInsulinism Market Barriers:
• Limited Awareness and Diagnosis
• Variability in Treatment Responses
• Side Effects of Current Therapies
• Limited Therapeutic Options for Severe Cases

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Scope of the Congenital HyperInsulinism Market Report:
• Study Period: 2020-2034
• Coverage: 7MM (The United States, EU5, and Japan)
• Key Congenital HyperInsulinism Companies: XOMA (US) LLC, Hanmi Pharmaceutical Company Limited, Zealand Pharma, Xeris Pharmaceuticals, Assistance Publique, Filip Krag Knop, Tracey McLaughlin
• Key Congenital HyperInsulinism Therapies: Cohort, HM15136, dasiglucagon, Glucagon, Sandostatine, Dasiglucagon, Lyo avexitide, Liq avexitide
• Congenital HyperInsulinism Therapeutic Assessment: Current marketed and emerging therapies
• Congenital HyperInsulinism Market Dynamics: Congenital HyperInsulinism Market drivers and Congenital HyperInsulinism barriers
• Competitive Intelligence Analysis: SWOT analysis, PESTLE analysis, Porter's five forces, BCG Matrix, Market entry strategies
• Congenital HyperInsulinism Unmet Needs: Insights into unmet needs, KOL's views, Analyst's views, Market Access, and Reimbursement.

To access the full report and gain a deeper understanding of Congenital HyperInsulinism market outlook, drug uptake, treatment scenario, and epidemiology trends, https://www.delveinsight.com/sample-request/congenital-hyperinsulinism-market?utm_source=openpr&utm_medium=pressrelease&utm_campaign=rkpr

Table of Content:

1. Key Insights
2. Report Introduction
3. Congenital Hyperinsulinism (CHI) Market Overview at a Glance
4. Executive Summary of Congenital Hyperinsulinism (CHI)
5. Key Events
6. Epidemiology and Market Methodology
7. Disease Background and Overview
8. Epidemiology and Patient Population
9. Patient Journey
10. Emerging Therapies
11. Congenital Hyperinsulinism: 7 Major Market Analysis
12. Market Access and Reimbursement
13. KOL Views
14. SWOT Analysis
15. Unmet Needs
16. Appendix
17. DelveInsight Capabilities
18. Disclaimer
19. About DelveInsight

About DelveInsight:
DelveInsight is a leading market research firm providing insightful solutions and services to pharmaceutical and life sciences companies. With a commitment to delivering accurate and comprehensive reports, DelveInsight empowers businesses to make informed decisions and navigate the complexities of the healthcare industry.

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