Acute Coronary Syndrome Market to Rise at a Significant CAGR | Regeneron, Sanofi, DalCor Pharmaceuticals, CSL Behring, and others expected to boost the market

DelveInsight's "Acute Coronary Syndrome - Market Insight, Epidemiology and Market Forecast - 2034" report provides current treatment practices, emerging drugs, Acute Coronary Syndrome market share of the individual therapies, current and forecasted Acute Coronary Syndrome market size from 2020 to 2034 segmented by seven major markets. The report also offers current Acute Coronary Syndrome therapy algorithms, market drivers, market barriers, and unmet medical needs to curate the best of the opportunities and assesses the underlying potential of the Acute Coronary Syndrome market.

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Key highlights from the acute coronary syndrome market report:
The epidemiology of Acute Coronary Syndrome (ACS) is likely to grow due to several factors. Firstly, an aging population worldwide contributes to a higher occurance of cardiovascular diseases, including ACS. Additionally, lifestyle changes such as unhealthy diets, sedentary lifestyles, and increasing rates of obesity are major risk factors for ACS.
The market dynamics for ACS are expected to undergo significant changes, with a shift towards personalized medicine and targeted therapies. There is a growing focus on precision medicine approaches, biomarker-guided treatments, and the integration of novel technologies such as artificial intelligence and genomic sequencing into ACS management.
Emerging therapies in the pipeline for ACS include novel antiplatelet agents, lipid-lowering drugs, anti-inflammatory agents, and gene therapies. These innovative treatments aim to address underlying pathophysiological mechanisms, improve efficacy, and reduce adverse events associated with current standard-of-care therapies.
Men are generally more prone to ACS compared to women. This higher susceptibility in men is attributed to biological factors such as hormonal differences (lower estrogen levels in men), genetic predisposition, and lifestyle factors like higher rates of smoking and alcohol consumption.

Acute Coronary Syndrome Overview
Acute Coronary Syndrome (ACS) refers to a spectrum of conditions resulting from reduced blood flow to the heart muscle, leading to chest pain and other serious complications. It encompasses three main clinical presentations: unstable angina, non-ST elevation myocardial infarction (NSTEMI), and ST elevation myocardial infarction (STEMI). ACS is a medical emergency that requires immediate intervention to prevent permanent heart damage or death.

Causes
The primary cause of ACS is the rupture of atherosclerotic plaques in the coronary arteries, which leads to the formation of a blood clot that obstructs blood flow. Other contributing factors include:

Coronary artery disease (CAD): The most common underlying condition.
Risk factors: High blood pressure, high cholesterol, smoking, diabetes, obesity, sedentary lifestyle, and family history of heart disease.
Stress: Physical or emotional stress can trigger ACS in susceptible individuals.
Signs and Symptoms
Common signs and symptoms of ACS include:

Chest Pain or Discomfort: Often described as a feeling of pressure, squeezing, fullness, or pain in the center or left side of the chest. It may radiate to the shoulders, neck, arms, back, teeth, or jaw.
Shortness of Breath: May occur with or without chest discomfort.
Nausea or Vomiting: Some individuals may experience gastrointestinal symptoms.
Cold Sweat: Sudden sweating without a clear cause.
Lightheadedness or Dizziness: A feeling of faintness or weakness.
Diagnosis
Diagnosis of ACS involves a combination of clinical evaluation and diagnostic tests, including:

Medical History and Physical Exam: Assessment of symptoms and risk factors.
Electrocardiogram (ECG): To identify ST-segment changes indicating ischemia or infarction.
Blood Tests: Measurement of cardiac biomarkers, such as troponin, which indicate heart muscle damage.
Imaging Studies: Echocardiogram or coronary angiography may be performed to evaluate heart function and blood flow.
Treatment Options
Treatment for ACS depends on the severity of the condition and may include:

Medications:

Antiplatelet Agents: Aspirin and P2Y12 inhibitors (e.g., clopidogrel) to prevent further clotting.
Anticoagulants: Such as heparin, to reduce blood clot formation.
Beta-Blockers: To lower heart rate and blood pressure.
ACE Inhibitors: To manage blood pressure and reduce heart strain.
Statins: To lower cholesterol levels.
Revascularization Procedures:

Percutaneous Coronary Intervention (PCI): Also known as angioplasty, where a balloon is used to open blocked arteries, often accompanied by the placement of a stent.
Coronary Artery Bypass Grafting (CABG): A surgical procedure that creates a new pathway for blood to flow to the heart by bypassing blocked arteries.
Lifestyle Modifications: Long-term management includes dietary changes, regular exercise, smoking cessation, and weight management to reduce the risk of future events.

Acute Coronary Syndrome is a critical medical condition that requires prompt recognition and intervention. Understanding its causes, signs, symptoms, diagnosis, and treatment options is vital for improving patient outcomes and preventing serious complications. If you suspect ACS, seek immediate medical attention.

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Acute Coronary Syndrome Epidemiological Insights
The incidence of Acute Coronary Syndrome (ACS) is anticipated to rise in the coming years due to several factors, particularly the increasing global burden of cardiovascular disease. Additionally, the changing epidemiological profile of ACS, with a concerning trend of affecting younger individuals, contributes to this expected increase.

While ACS primarily affects men under the age of 60, women represent the majority of ACS patients over 75. Overall, while ACS is more prevalent in men, women tend to present at an older age, experience more atypical symptoms, receive less aggressive treatment, and face higher short-term mortality, particularly among younger women.

Among the different types of Acute Coronary Syndrome, Non-ST-Segment Elevation Myocardial Infarction (NSTEMI) has a higher incidence compared to ST-Segment Elevation Myocardial Infarction (STEMI) and unstable angina. In the United States, approximately 70% of ACS cases are classified as NSTEMI, making it the most common form within the ACS spectrum.

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Acute Coronary Syndrome Treatment Market
The primary objective in managing Acute Coronary Syndrome (ACS) is to swiftly restore blood flow to the ischemic myocardium, thereby minimizing myocardial damage and preventing complications such as heart failure and arrhythmias. Treatment also focuses on alleviating symptoms, stabilizing the patient's condition, and reducing the risk of recurrent cardiovascular events. Long-term management emphasizes secondary prevention strategies to address the underlying disease process and improve patient outcomes.

Current treatment options for ACS include:

- **Antiplatelet Therapy (e.g., Aspirin)**: Aspirin inhibits the activity of the cyclooxygenase (COX) enzyme, reducing the production of thromboxane A2, a potent platelet aggregator. By preventing platelet activation and aggregation, aspirin decreases the risk of thrombus formation and subsequent coronary artery blockage.

- **P2Y12 Inhibitors (e.g., Clopidogrel)**: Clopidogrel selectively blocks the P2Y12 receptor on platelets, inhibiting adenosine diphosphate (ADP)-mediated platelet activation and aggregation. This action helps prevent the amplification of platelet aggregation, thereby lowering the risk of thrombotic events in patients with ACS.

- **Beta-Blockers**: Medications such as metoprolol and atenolol are integral to ACS management, as they reduce the heart's workload and oxygen demand. This stabilization helps prevent the heart from overexerting itself.

- **ACE Inhibitors and Angiotensin Receptor Blockers (ARBs)**: Drugs like lisinopril and losartan help relax blood vessels and lower blood pressure, reducing strain on the heart.

- **Statins**: Atorvastatin and rosuvastatin play a crucial role in lowering cholesterol levels and stabilizing arterial plaques, helping to prevent further blockages in coronary arteries.

- **Nitrates**: Medications such as nitroglycerin relieve chest pain by dilating blood vessels, improving blood flow, and decreasing cardiac workload. Additionally, analgesics are used to manage discomfort associated with ACS.

Beyond pharmacological treatments, lifestyle modifications and cardiac rehabilitation are essential components of ACS management. Patients are encouraged to adopt healthier habits, including smoking cessation, dietary changes, and regular physical activity. Cardiac rehabilitation programs offer structured exercise and educational sessions aimed at enhancing cardiovascular health and preventing future incidents.

With ongoing research and dedication, there is hope for even more effective treatments and potential cures for this complex condition. According to DelveInsight, the Acute Coronary Syndrome (ACS) market across the seven major markets (7MM) is expected to undergo significant changes during the study period from 2020 to 2034.



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Promising Therapies in the Acute Coronary Syndrome Pipeline
● Alirocumab
● Dalcetrapib
● CSL112
● And others

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Leading Companies Working in the Acute Coronary Syndrome Market
● Regeneron/ Sanofi
● DalCor Pharmaceuticals
● CSL Behring
● And others
To understand key companies related to the Acute Coronary Syndrome Market, get a snapshot of the Acute Coronary Syndrome Regulatory and Patent Analysis @ https://www.delveinsight.com/report-store/acute-coronary-syndrome-market?utm_source=openpr&utm_medium=pressrelease&utm_campaign=kpr

Acute Coronary Syndrome (ACS) Marketed Drugs
BRILINTA (Ticagrelor): AstraZeneca
BRILINTA is an oral antiplatelet medication used for managing Acute Coronary Syndrome (ACS). Its active ingredient, ticagrelor, is classified as a P2Y12 receptor antagonist. By reversibly binding to the P2Y12 receptor on platelets, ticagrelor inhibits ADP-induced platelet activation and aggregation, leading to reduced thrombus formation and subsequent cardiovascular events. BRILINTA is taken orally, typically starting with a loading dose followed by maintenance therapy. It is available in tablet form, facilitating easy administration and patient adherence.

Acute Coronary Syndrome (ACS) Emerging Drugs
IMT-358: IMMEDIATE Therapeutics
IMT-358 is an investigational drug being developed by IMMEDIATE Therapeutics, aimed at providing metabolic protection to minimize cardiac damage and instability during ACS. While its exact mechanism of action is still under investigation, IMT-358 components supply glucose to heart tissue, potentially sustaining metabolism and preventing arrhythmias. Additionally, insulin in the formulation may serve as an anti-apoptotic and anti-inflammatory agent.

Milvexian: Bristol Myers Squibb/Janssen Research & Development, LLC
Milvexian is an investigational oral factor XIa (FXIa) inhibitor being studied for the prevention and treatment of major thrombotic conditions as part of the Librexia program, the most extensive FXIa clinical development program to date. In May 2023, Milvexian received Fast Track Designation from the US FDA for all three indications under evaluation in the Phase III LIBREXIA program: ischemic stroke, acute coronary syndrome, and atrial fibrillation.

Dalcetrapib: DalCor Pharmaceuticals
Dalcetrapib is the lead candidate from DalCor Pharmaceuticals and is a cholesteryl ester transfer protein (CETP) inhibitor. It works by blocking CETP, which facilitates the transfer of cholesterol from HDL (high-density lipoprotein) to LDL (low-density lipoprotein). By inhibiting CETP, dalcetrapib aims to elevate HDL levels, potentially reducing the risk of cardiovascular events. Unlike previous CETP inhibitors, dalcetrapib specifically targets a genetic variant associated with increased HDL levels. In clinical trials, it has shown promise in improving cardiovascular outcomes, particularly among individuals with this genetic variant. Currently in Phase III trials, dalcetrapib offers a novel approach to managing cardiovascular risk.

Scope of the Acute Coronary Syndrome Market Report
Study Period: 2020-2034
Coverage: 7MM [The United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom), Japan]
Key Acute Coronary Syndrome Companies: Regeneron/ Sanofi, DalCor Pharmaceuticals, CSL Behring, and others.
Key Acute Coronary Syndrome Pipeline Therapies: Alirocumab, Dalcetrapib,CSL112, and others.
Therapeutic Assessment: Acute Coronary Syndrome current marketed and emerging therapies
Acute Coronary Syndrome Market Dynamics: Acute Coronary Syndrome market drivers and barriers
Competitive Intelligence Analysis: SWOT analysis, PESTLE analysis, Porter's five forces, BCG Matrix, Market entry strategies
Unmet Needs, KOL's views, Analyst's views, Acute Coronary Syndrome Market Access and Reimbursement

Table of Contents
1. Acute Coronary Syndrome Market Key Insights
2. Acute Coronary Syndrome Market Report Introduction
3. Acute Coronary Syndrome Market Overview at a Glance
4. Acute Coronary Syndrome Market Executive Summary
5. Disease Background and Overview
6. Acute Coronary Syndrome Treatment and Management
7. Acute Coronary Syndrome Epidemiology and Patient Population
8. Patient Journey
9. Acute Coronary Syndrome Emerging Drugs
10. 7MM Acute Coronary Syndrome Market Analysis
11. Acute Coronary Syndrome Market Outlook
12. Potential of Current and Emerging Therapies
13. KOL Views
14. Acute Coronary Syndrome Market Drivers
15. Acute Coronary Syndrome Market Barriers
16. Unmet Needs
17. SWOT Analysis
18. Appendix
19. DelveInsight Capabilities
20. Disclaimer
21. About DelveInsight

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