ANCA Vasculitis Market to Rise by 2032 | AstraZeneca, GlaxoSmithKline, Travere Therapeutics

DelveInsight's "ANCA Vasculitis Market Insights, Epidemiology, and Market Forecast-2032" report delivers an in-depth understanding of ANCA Vasculitis, historical and forecasted epidemiology as well as the ANCA Vasculitis market trends in the United States, EU5 (Germany, Spain, Italy, France, and United Kingdom), and Japan.

The ANCA Vasculitis market report provides current treatment practices, emerging drugs, the market share of the individual therapies, and the current and forecasted ANCA Vasculitis market size from 2019 to 2032, segmented by seven major markets. The Report also covers current ANCA Vasculitis treatment practice/algorithm, market drivers, market barriers, and unmet medical needs to curate the best opportunities and assesses the underlying potential of the ANCA Vasculitis market.

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Key highlights from the ANCA vasculitis market report:

The total market size for ANCA-associated vasculitis in the 7MM was approximately USD 1,500 million in 2023. This market is projected to grow significantly over the forecast period, driven by the launch of new therapies such as Benralizumab (AstraZeneca) and depemokimab (GlaxoSmithKline), among others.

ANCA-associated vasculitis comprises a diverse group of rare autoimmune disorders characterized by inflammation of blood vessels, which can manifest in various ways. The three main types include granulomatosis with polyangiitis (GPA), formerly known as Wegener granulomatosis; eosinophilic granulomatosis with polyangiitis (EGPA), previously called Churg-Strauss syndrome; and microscopic polyangiitis (MPA).

According to DelveInsight, there were approximately 214,800 diagnosed prevalent cases of ANCA-associated vasculitis in the 7MM in 2023, with the highest number of cases reported in the US, followed by Japan. Among the three types, granulomatosis with polyangiitis (GPA) is more prevalent than microscopic polyangiitis (MPA) and eosinophilic granulomatosis with polyangiitis (EGPA). While MPA has a higher incidence, its prevalence is lower due to patients presenting with more severe manifestations at diagnosis, leading to higher mortality rates.

Triggers for ANCA-associated vasculitis may include microbial infections, reactions to certain medications, specific genetic variations, or exposure to environmental toxins. Treatment typically consists of two phases: remission-induction and remission-maintenance. The induction phase usually involves cyclophosphamide, rituximab, and high-dose steroids, while maintenance therapy may include methotrexate or azathioprine.

Current therapies effectively induce and maintain remission but can carry various toxicities. For patients with relapsing or refractory disease who do not respond to cyclophosphamide or glucocorticoids, treatments such as rituximab, NUCALA (for GPA/MPA), and TAVNEOS (for EGPA) may be prescribed. In 2021, the US FDA approved TAVNEOS (avacopan) as an adjunctive treatment for adult patients with severe active ANCA-associated vasculitis, specifically for GPA and MPA in conjunction with standard therapy.

Patients with ANCA-associated vasculitis often experience delays in obtaining an accurate diagnosis, which can lead to significant morbidity and increased mortality. Therefore, there is a critical need for effective early diagnosis and reliable biomarkers to facilitate the early detection of this condition.

ANCA Vasculitis Overview

ANCA (Anti-Neutrophil Cytoplasmic Antibody) vasculitis is a group of autoimmune diseases characterized by inflammation of blood vessels (vasculitis) due to the presence of ANCA antibodies. This inflammation can affect various organs, leading to a range of symptoms depending on the specific type of vasculitis and the organs involved.

Causes
The exact cause of ANCA vasculitis is not fully understood, but it is believed to involve a combination of genetic, environmental, and immunological factors. Possible triggers include:

Infections: Certain infections may provoke the immune system, leading to an autoimmune response.
Medications: Some drugs, such as certain antibiotics or anti-seizure medications, have been associated with the development of ANCA vasculitis.
Genetic Predisposition: A family history of autoimmune diseases may increase the risk.
Signs and Symptoms
The symptoms of ANCA vasculitis can vary widely but often include:

General Symptoms: Fever, fatigue, weight loss, and malaise.
Respiratory Symptoms: Cough, shortness of breath, and nasal symptoms such as sinusitis or nosebleeds.
Renal Symptoms: Blood in the urine, reduced urine output, or kidney dysfunction.
Skin Symptoms: Rash, purpura (purple spots), or ulcers.
Nervous System Symptoms: Numbness, tingling, or weakness due to nerve involvement.
Diagnosis
Diagnosing ANCA vasculitis typically involves:

Medical History and Physical Examination: Assessing symptoms and any relevant medical history.
Blood Tests: Measuring levels of ANCA antibodies and assessing kidney function and inflammation markers.
Urinalysis: Checking for blood or protein in the urine.
Imaging Studies: CT scans or MRIs may be used to evaluate organ involvement.
Biopsy: In some cases, a biopsy of affected tissue (such as kidney or lung tissue) may be necessary to confirm the diagnosis.
Treatment Options
Treatment for ANCA vasculitis aims to reduce inflammation, manage symptoms, and prevent organ damage. Options include:

Corticosteroids: Medications like prednisone are commonly used to quickly reduce inflammation.
Immunosuppressive Drugs: Agents such as cyclophosphamide, rituximab, or azathioprine help suppress the immune system to prevent further damage.
Plasmapheresis: A procedure that removes ANCA antibodies from the blood, used in severe cases, especially with kidney involvement.
Supportive Care: This may include medications to manage symptoms, such as antihypertensives for high blood pressure or treatment for kidney dysfunction.

ANCA vasculitis is a serious condition requiring prompt diagnosis and treatment to prevent significant organ damage. Early recognition and a tailored treatment approach can lead to improved outcomes and quality of life for affected individuals. Regular follow-up and monitoring are essential to manage the disease effectively.

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ANCA Vasculitis Market

Current treatment guidelines for ANCA-associated vasculitis focus on halting vasculitic activity, preventing relapse, and managing long-term complications resulting from tissue damage, drug toxicity, and heightened risks of cardiovascular issues and malignancies. The standard treatment approach typically begins with induction therapy using cyclophosphamide or rituximab alongside glucocorticoids, followed by a maintenance phase with rituximab, azathioprine, or methotrexate, during which glucocorticoids are gradually reduced. While these therapies are generally effective in inducing and maintaining remission, they can lead to various toxicities.

Rituximab is frequently preferred for remission induction due to its efficacy and comparable safety profile. Common dosing regimens include 375 mg/m² weekly for four weeks or 1,000 mg administered twice over two weeks. Cyclophosphamide remains a mainstay of treatment for many providers, especially in cases where rituximab is cost-prohibitive. Although the short follow-up duration in the RAVE trial limited long-term outcome assessments-such as cancer risk and survival-recent observational studies indicate that rituximab does not appear to increase the risk of malignancy compared to cyclophosphamide.

Several new agents with innovative mechanisms are also under investigation for ANCA-associated vasculitis, including belimumab (B-cell activating factor inhibitors), sparsentan (angiotensin type 1 receptor antagonists), and NS-229 (selective JAK1 inhibitor), among others.

In summary, there are promising therapies currently being explored for managing ANCA-associated vasculitis. While it may be premature to predict the market entry of these candidates during the forecast period (2024-2034), the future looks promising. These developments are expected to significantly enhance the treatment landscape for ANCA-associated vasculitis in the coming years, particularly as global healthcare spending continues to rise.

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ANCA Vasculitis Epidemiology

According to estimates from DelveInsight, the United States held the largest market share for ANCA-associated vasculitis among the 7MM in 2023, followed by Japan. Based on DelveInsight's patient-based forecasting model, NUCALA (mepolizumab) and rituximab had the highest market share among available therapies in the 7MM for that year.

Looking ahead, TAVNEOS (avacopan) is projected to generate over USD 1 billion in revenue by 2034. Among emerging therapies, FASENRA (benralizumab) is anticipated to outperform others, such as GSK3511294 (depemokimab), in terms of revenue generation.

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ANCA Vasculitis Drugs Uptake

This section focuses on the uptake rate of the potential ANCA Vasculitis drugs recently launched in the ANCA Vasculitis market or expected to be launched in 2019-2032. The analysis covers the ANCA Vasculitis market uptake by drugs, patient uptake by therapies, and sales of each drug.

ANCA Vasculitis Drugs Uptake helps in understanding the drugs with the most rapid uptake and the reasons behind the maximal use of new drugs and allows the comparison of the drugs based on ANCA Vasculitis market share and size, which again will be useful in investigating factors important in market uptake and in making financial and regulatory decisions.

ANCA Vasculitis Pipeline Development Activities

The ANCA Vasculitis report provides insights into different therapeutic candidates in Phase II, and Phase III stages. It also analyzes ANCA Vasculitis key players involved in developing targeted therapeutics.

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ANCA Vasculitis Therapeutics Assessment

Major pharma companies such as AstraZeneca, GlaxoSmithKline, Travere Therapeutics, and others are working proactively in the ANCA Vasculitis Therapeutics market to develop novel therapies which will drive the ANCA Vasculitis treatment markets in the upcoming years.

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ANCA Vasculitis Report Key Insights

1. ANCA Vasculitis Patient Population
2. ANCA Vasculitis Market Size and Trends
3. Key Cross Competition in the ANCA Vasculitis Market
4. ANCA Vasculitis Market Dynamics (Key Drivers and Barriers)
5. ANCA Vasculitis Market Opportunities
6. ANCA Vasculitis Therapeutic Approaches
7. ANCA Vasculitis Pipeline Analysis
8. ANCA Vasculitis Current Treatment Practices/Algorithm
9. Impact of Emerging Therapies on the ANCA Vasculitis Market

Table of Contents

1. Key Insights
2. Executive Summary
3. ANCA Vasculitis Competitive Intelligence Analysis
4. ANCA Vasculitis Market Overview at a Glance
5. ANCA Vasculitis Disease Background and Overview
6. ANCA Vasculitis Patient Journey
7. ANCA Vasculitis Epidemiology and Patient Population
8. ANCA Vasculitis Treatment Algorithm, Current Treatment, and Medical Practices
9. ANCA Vasculitis Unmet Needs
10. Key Endpoints of ANCA Vasculitis Treatment
11. ANCA Vasculitis Marketed Products
12. ANCA Vasculitis Emerging Therapies
13. ANCA Vasculitis Seven Major Market Analysis
14. Attribute Analysis
15. ANCA Vasculitis Market Outlook (7 major markets)
16. ANCA Vasculitis Access and Reimbursement Overview
17. KOL Views on the ANCA Vasculitis Market
18. ANCA Vasculitis Market Drivers
19. ANCA Vasculitis Market Barriers
20. Appendix
21. DelveInsight Capabilities
22. Disclaimer

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