Chronic Liver Disease Market to Rise by 2032 | Astellas Pharma, Bristol-Myers Squibb, Gilead Sciences, GlaxoSmithKline, F. Hoffmann-La Roche, Merck, Novartis, Sanofi, Pfizer, and others

DelveInsight's "Chronic Liver Disease Market Insights, Epidemiology, and Market Forecast-2032" report delivers an in-depth understanding of Chronic Liver Disease, historical and forecasted epidemiology as well as the Chronic Liver Disease market trends in the United States, EU5 (Germany, Spain, Italy, France, and United Kingdom), and Japan.

The Chronic Liver Disease market report provides current treatment practices, emerging drugs, the market share of the individual therapies, and the current and forecasted Chronic Liver Disease market size from 2019 to 2032, segmented by seven major markets. The Report also covers current Chronic Liver Disease treatment practice/algorithm, market drivers, market barriers, and unmet medical needs to curate the best opportunities and assesses the underlying potential of the Chronic Liver Disease market.

Key highlights from the chronic liver disease market report:

The chronic liver disease market is expected to undergo significant changes driven by rising prevalence, enhanced diagnostic methods, and evolving treatment options, including advancements in the therapeutic portfolio. The primary goal of treating chronic liver disease is to halt disease progression and manage complications, focusing on correcting the underlying causes, addressing portal hypertension, and providing specific treatments for individual conditions.
Chronic liver disease presents a considerable burden, particularly due to the lack of effective approved pharmacological therapies. The slow pace of drug approvals by regulatory authorities hampers growth in the pharmaceutical market. Organ transplantation remains a treatment option for patients with end-stage liver disease and is becoming an increasingly substantial market on its own.
However, there is optimism for the future, as new medications are expected to emerge during the forecast period. Notable candidates include semaglutide from Gilead Sciences, Inc. and Novo Nordisk A/S, as well as Madrigal's lead candidate, Resmetirom (formerly MGL-3196). Various early and mid-stage clinical development candidates are also emerging, aiming to address a wide range of unmet needs, including both the underlying causes of chronic liver disease and its associated complications.

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Chronic Liver Disease Overview

Chronic liver disease (CLD) refers to long-term damage to the liver, resulting in impaired liver function. It encompasses a range of conditions, including chronic hepatitis, cirrhosis, fatty liver disease, and liver cancer. Over time, chronic liver disease can lead to serious complications, including liver failure.

Causes
The causes of chronic liver disease can vary widely and include:

Chronic Viral Infections: Hepatitis B and C are the most common viral causes.
Alcohol Abuse: Prolonged excessive alcohol consumption can damage liver cells.
Non-Alcoholic Fatty Liver Disease (NAFLD): Often associated with obesity, diabetes, and metabolic syndrome.
Autoimmune Diseases: Conditions like autoimmune hepatitis can cause the immune system to attack liver cells.
Genetic Disorders: Conditions such as hemochromatosis and Wilson's disease can lead to liver damage.
Medications and Toxins: Long-term use of certain medications or exposure to toxins can harm the liver.
Signs and Symptoms
Chronic liver disease may not show symptoms in its early stages, but as it progresses, common signs and symptoms can include:

Fatigue: Persistent tiredness and weakness.
Jaundice: Yellowing of the skin and eyes due to elevated bilirubin levels.
Abdominal Swelling: Fluid accumulation (ascites) can cause bloating.
Itchy Skin: Generalized itching without a rash.
Loss of Appetite: Reduced desire to eat, potentially leading to weight loss.
Nausea and Vomiting: Gastrointestinal discomfort may occur.
Easy Bruising and Bleeding: Due to impaired production of clotting factors.
Diagnosis
Diagnosis of chronic liver disease typically involves:

Medical History and Physical Examination: Discussing symptoms and risk factors, along with a physical exam.
Blood Tests: Liver function tests, hepatitis panel, and tests for liver enzymes and bilirubin levels.
Imaging Studies: Ultrasound, CT scans, or MRIs to visualize liver structure and assess for damage or tumors.
Liver Biopsy: A sample of liver tissue may be taken to evaluate the extent of damage and underlying cause.
Treatment Options
Treatment for chronic liver disease focuses on managing the underlying cause and preventing further damage. Options may include:

Lifestyle Changes:

Dietary Modifications: Adopting a balanced diet low in fat and sugar.
Alcohol Cessation: Eliminating alcohol intake is crucial for liver health.
Weight Management: Achieving and maintaining a healthy weight, particularly for those with NAFLD.
Medications:

Antivirals: For chronic hepatitis B and C infections.
Immunosuppressants: For autoimmune liver diseases.
Diuretics: To manage fluid retention in cases of ascites.
Surgical Interventions:

Liver Transplant: In cases of severe liver failure or cirrhosis where other treatments are ineffective.
Regular Monitoring: Ongoing follow-up with healthcare providers to assess liver function and manage complications.

Early diagnosis and intervention are key to managing chronic liver disease effectively and improving outcomes.

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Chronic Liver Disease Market

The management of patients with chronic liver disease varies depending on the stage of the disease. Liver fibrosis and cirrhosis often result from underlying conditions such as NASH, ALD, CHB, and CHC, which progress to a severe chronic state due to the absence of standardized treatments.

According to the American Liver Foundation guidelines, without any branded drug approvals, managing the underlying comorbidities central to treating NASH and associated fibrosis is crucial. Various off-label therapies are employed to address complications of chronic liver disease, including vitamin E (an antioxidant), insulin sensitizers (such as metformin and pioglitazone), anti-hyperlipidemic agents (like gemfibrozil), pentoxifylline, and UDCA.

DelveInsight reports that the chronic liver disease market is anticipated to undergo significant changes across the 7MM during the study period from 2019 to 2032.

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Chronic Liver Disease Epidemiology

According to Ginès et al. (2016), the prevalence of increased liver stiffness in the general adult population without previously known liver diseases is significant, ranging from 5.6% to 7.5%. Among individuals with risk factors, this prevalence is even higher, falling between 18% and 27%, indicating a concerning rate of chronic liver diseases in the general population.

Axley et al. (2018) describe fibrosis stages ranging from F0 to F4, with advanced liver fibrosis being a critical predictor of disease progression and mortality. Current guidelines recommend screening for complications of cirrhosis once patients reach F3 fibrosis.

Ginès et al. (2016) also report that studies indicate 6-7% of adults without known liver disease have liver fibrosis, predominantly linked to non-alcoholic fatty liver disease.

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Chronic Liver Disease Drugs Uptake

This section focuses on the uptake rate of the potential Chronic Liver Disease drugs recently launched in the Chronic Liver Disease market or expected to be launched in 2019-2032. The analysis covers the Chronic Liver Disease market uptake by drugs, patient uptake by therapies, and sales of each drug.

Chronic Liver Disease Drugs Uptake helps in understanding the drugs with the most rapid uptake and the reasons behind the maximal use of new drugs and allows the comparison of the drugs based on Chronic Liver Disease market share and size, which again will be useful in investigating factors important in market uptake and in making financial and regulatory decisions.

Chronic Liver Disease Emerging Drugs

Semaglutide: Novo Nordisk

Resmetirom (formerly MGL-3196): Madrigal Pharmaceuticals

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Chronic Liver Disease Therapeutics Assessment

Major key companies such as Astellas Pharma, Bristol-Myers Squibb, Gilead Sciences, GlaxoSmithKline, F. Hoffmann-La Roche, Merck & Co., Novartis AG, Sanofi, Pfizer, and others are working proactively in the Chronic Liver Disease Therapeutics market to develop novel therapies which will drive the Chronic Liver Disease treatment markets in the upcoming years.

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Chronic Liver Disease Report Key Insights

1. Chronic Liver Disease Patient Population
2. Chronic Liver Disease Market Size and Trends
3. Key Cross Competition in the Chronic Liver Disease Market
4. Chronic Liver Disease Market Dynamics (Key Drivers and Barriers)
5. Chronic Liver Disease Market Opportunities
6. Chronic Liver Disease Therapeutic Approaches
7. Chronic Liver Disease Pipeline Analysis
8. Chronic Liver Disease Current Treatment Practices/Algorithm
9. Impact of Emerging Therapies on the Chronic Liver Disease Market

Table of Contents

1. Key Insights
2. Executive Summary
3. Chronic Liver Disease Competitive Intelligence Analysis
4. Chronic Liver Disease Market Overview at a Glance
5. Chronic Liver Disease Disease Background and Overview
6. Chronic Liver Disease Patient Journey
7. Chronic Liver Disease Epidemiology and Patient Population
8. Chronic Liver Disease Treatment Algorithm, Current Treatment, and Medical Practices
9. Chronic Liver Disease Unmet Needs
10. Key Endpoints of Chronic Liver Disease Treatment
11. Chronic Liver Disease Marketed Products
12. Chronic Liver Disease Emerging Therapies
13. Chronic Liver Disease Seven Major Market Analysis
14. Attribute Analysis
15. Chronic Liver Disease Market Outlook (7 major markets)
16. Chronic Liver Disease Access and Reimbursement Overview
17. KOL Views on the Chronic Liver Disease Market
18. Chronic Liver Disease Market Drivers
19. Chronic Liver Disease Market Barriers
20. Appendix
21. DelveInsight Capabilities
22. Disclaimer

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