Wilson's Disease Market Size is Set for Rapid Growth as Innovative Treatments and Rising Awareness Drive Demand by 2034

The Wilson's Disease market size is expected to increase during the forecast period with the increasing prevalence, disease awareness, and promising emerging treatment options by leading companies such as Orphalan, AstraZeneca, Vivet Therapeutics, Pfizer, Ultragenyx Pharmaceutical, Vivet Therapeutics SAS, Nobelpharma, Alexion Pharmaceuticals, Inc.,

[Nevada, United States] - DelveInsight's "Wilson's Disease Market Insights, Epidemiology, and Market Forecast 2034." report offers a detailed examination of Wilson's Disease, covering historical and predicted epidemiology, market trends, and treatment scenarios in the United States, EU4 (Germany, Spain, Italy, France), the United Kingdom, and Japan.

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Key Findings from the Wilson's Disease Market Report:
The Wilson's Disease market size is poised for significant growth, with an anticipated Compound Annual Growth Rate (CAGR) during the study period (2020-2034).
In August, 2024: Ultragenyx Pharmaceutical Inc announced that the main aim for their study is to evaluate the safety of single IV doses of UX701 in patients with Wilson disease, to select the UX701 dose with the best benefit/risk profile based on the totality of safety and efficacy data and to evaluate the effect of UX701 on copper regulation.
In July, 2024: Alexion Pharmaceuticals, Inc. announced that their study aims to evaluate the change in liver copper (Cu) concentration following 48 weeks of treatment with ALXN1840 in adult participants with Wilson Disease (WD) who have been previously treated for at least 1 year with standard of care (that is, trientine, penicillamine, or zinc).
In June, 2024: Alexion Pharmaceuticals, Inc. announced that their exploratory study will investigate the effects of ALXN1840 on copper balance in participants with Wilson disease (WD).
In June, 2024: Orphalan announced a a multicenter, randomized, open-label study with an active standard-of-care comparator (penicillamine). Stable patients who are already considered to be stable on their standard-of-care penicillamine chelation therapy for at least 1 year will enroll in the study and enter a 12-week Penicillamine Baseline Period comprising of 1 month (4 weeks) run-in period followed by a 2 month (8 weeks) evaluation period.
According to DelveInsight's estimate, the total diagnosed prevalent cases of Wilson's disease in the 7MM were approximately 8 thousand in 2023. These cases are expected to increase during the forecast period (2024-2034).
In 2023, the market size of Wilson's Disease was highest in the US among the 7MM accounting for approximately USD 126 million that is further expected to increase at a CAGR of 13%.
The current treatment strategies mainly rely upon the use of Chelating agents (D-penicillamine, trientine), Zinc Salts, and others. Chelating agents accounted for the highest market share of ~123 million in 2023, for treatment of Wilson's Disease in the US.
Key Wilson's Disease Companies are as follows: Orphalan, AstraZeneca, Vivet Therapeutics, Pfizer, Ultragenyx Pharmaceutical, Vivet Therapeutics SAS, Nobelpharma, Alexion Pharmaceuticals, Inc.,
Key Wilson's Disease Therapies are as follow:VTX-801, NPC-02:, ALXN1840, UX70Bis-Choline Tetrathiomolybdate, Penicillamine. TETA 4HCL and more...
Launching multiple stage Wilson's Disease pipeline products is expected to revolutionize market dynamics, further propelling market growth.

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Wilson's Disease Overview:
Wilson's disease is a rare genetic disorder that leads to excessive accumulation of copper in the body, primarily in the liver, brain, and other vital organs. It is caused by mutations in the ATP7B gene, which is responsible for regulating copper transport in the liver. In a healthy individual, excess copper is excreted into bile and eliminated from the body.

Wilson's Disease Epidemiology Segmentation:
The Wilson's Disease market report proffers epidemiological analysis for the study period 2020-2034 in the 7MM segmented into:
Wilson's Disease Total Prevalence
Wilson's Disease Prevalent Cases by severity
Wilson's Disease Gender-specific Prevalence
Wilson's Disease Diagnosed Cases of Episodic and Chronic

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Wilson's Disease Market Insights
The Wilson's Disease market has seen significant growth in recent years, driven by an increase in awareness and advancements in genetic testing and diagnostic tools. The market is segmented into treatment approaches that include chelation therapy and zinc-based therapies, along with newer therapeutic candidates. Current treatments focus on reducing copper levels in the body and managing symptoms, but there is a growing pipeline of novel therapies aimed at addressing unmet needs in disease management.

Wilson's Disease Drugs Uptake
Chelation Therapy: Chelation therapy, the primary treatment option for Wilson's disease, involves the use of agents such as penicillamine and trientine to bind copper and facilitate its excretion from the body. Despite being effective, these drugs are often associated with side effects like joint pain, nausea, and hematological abnormalities.
Zinc-Based Therapy: Zinc salts, such as zinc acetate, are another treatment option that works by blocking copper absorption in the intestines. Zinc-based therapy is usually recommended for maintenance therapy in patients who have achieved initial copper reduction with chelation therapy.
Emerging Therapies: Recent years have witnessed the emergence of innovative therapies aimed at improving patient outcomes. WTX101 (TETA-4), an investigational oral therapy developed by Alexion Pharmaceuticals, is showing promise in clinical trials. It acts by binding excess copper and facilitating its excretion, potentially offering a more convenient and effective treatment option.
Gene Therapy: With advancements in gene-editing technologies, gene therapy is being explored as a potential curative approach. This form of therapy seeks to correct the underlying genetic defect by delivering a functional ATP7B gene to liver cells.

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Wilson's Disease Therapies and Key Companies:
VTX-801: Vivet Therapeutics SAS
NPC-02: Nobelpharma
ALXN1840: Alexion Pharmaceuticals, Inc.
UX701: Ultragenyx Pharmaceutical Inc
Bis-Choline Tetrathiomolybdate:
Alexion Pharmaceuticals, Inc.
Penicillamine. TETA 4HCL: Orphalan

Wilson's Disease Epidemiology:
Wilson's disease is a rare condition, affecting approximately 1 in 30,000 people globally. The disease is autosomal recessive, meaning a person needs to inherit two copies of the defective gene (one from each parent) to develop the condition. The actual prevalence is likely underestimated due to the rarity of the disease and misdiagnosis, as its symptoms can mimic those of other hepatic or neuropsychiatric disorders.

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Wilson's Disease Market Drivers:
Increased Awareness and Early Diagnosis
Novel Drug Development
Rising Demand for Personalized Medicine

Wilson's Disease Market Barriers:
Adverse Effects of Current Therapies
Misdiagnosis and Delayed Diagnosis
Limited Market Penetration in Developing Regions

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Scope of the Wilson's Disease Market Report:
Study Period: 2020-2034
Coverage: 7MM (The United States, EU5, and Japan)
Key Wilson's Disease Companies: Orphalan, AstraZeneca, Vivet Therapeutics, Pfizer, Ultragenyx Pharmaceutical, Vivet Therapeutics SAS, Nobelpharma, Alexion Pharmaceuticals, Inc.,
Key Wilson's Disease Therapies: VTX-801, NPC-02:, ALXN1840, UX70Bis-Choline Tetrathiomolybdate, Penicillamine. TETA 4HCL and more...
Wilson's Disease Therapeutic Assessment: Current marketed and emerging therapies
Wilson's Disease Market Dynamics: Wilson's Disease Market drivers and Wilson's Disease barriers
Competitive Intelligence Analysis: SWOT analysis, PESTLE analysis, Porter's five forces, BCG Matrix, Market entry strategies
Wilson's Disease Unmet Needs: Insights into unmet needs, KOL's views, Analyst's views, Market Access, and Reimbursement.

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Table of Content:

1. Key Insights
2. Report Introduction
3. Wilson's disease Market Overview at a Glance
4. Executive Summary of Wilson's disease
5. Disease Background and Overview
6. Patient Journey
7. Epidemiology and Patient Population
8. Marketed Therapies
9. Emerging Therapies
10. Wilson's disease: 7 Major Market Analysis
11. Market Access
12. SWOT Analysis
13. Unmet Needs
14. Appendix
15. DelveInsight Capabilities
16. Disclaimer
17. About DelveInsight

About DelveInsight:
DelveInsight is a leading market research firm providing insightful solutions and services to pharmaceutical and life sciences companies. With a commitment to delivering accurate and comprehensive reports, DelveInsight empowers businesses to make informed decisions and navigate the complexities of the healthcare industry.

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