Acute Kidney Injury Market to Grow Positively at a Paltry CAGR During the Study Period (2020-2034) | Sentien Biotechnologies, Guard Therapeutics, Ocelot Bio, Renibus Therapeutics, expected to boost the market

United States, Nevada, Las Vegas, DelveInsight's "Acute Kidney Injury - Market Insight, Epidemiology and Market Forecast - 2034" report provides current treatment practices, emerging drugs, Acute Kidney Injury market share of the individual therapies, current and forecasted Acute Kidney Injury market size from 2020 to 2034 segmented by seven major markets. The report also offers current Acute Kidney Injury therapy algorithms, market drivers, market barriers, and unmet medical needs to curate the best of the opportunities and assesses the underlying potential of the Acute Kidney Injury market.
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Acute Kidney Injury Overview
Overview

Acute Kidney Injury (AKI), formerly known as acute renal failure, is a sudden and rapid decline in kidney function that occurs over hours to days. This condition is characterized by a rise in serum creatinine levels and/or a reduction in urine output. AKI can result in the accumulation of waste products and fluid imbalances, which can impact overall health and organ function.

Causes

AKI can be categorized into three main types based on its origin:

1. Prerenal AKI: Caused by reduced blood flow to the kidneys, leading to impaired kidney function.
- Dehydration: Due to excessive fluid loss from vomiting, diarrhea, or sweating.
- Hypovolemia: From bleeding or severe fluid loss.
- Heart Failure: Reduced cardiac output affecting kidney perfusion.
- Renal Artery Stenosis: Narrowing of the arteries supplying the kidneys.

2. Intrarenal AKI: Resulting from direct damage to the kidney tissue.
- Acute Tubular Injury: Often due to ischemia or nephrotoxic substances (e.g., certain medications, contrast agents).
- Glomerulonephritis: Inflammation of the kidney's filtering units.
- Acute Interstitial Nephritis: Inflammation of the kidney's interstitial tissue, often due to allergic reactions or infections.

3. Postrenal AKI: Due to obstruction in the urinary tract that impedes urine flow.
- Urinary Tract Obstruction: From kidney stones, tumors, or enlarged prostate.
- Bladder Outlet Obstruction: Causing urine to back up into the kidneys.

Signs and Symptoms

Symptoms of AKI can vary but commonly include:

- Reduced Urine Output: Oliguria (low urine output) or anuria (no urine output).
- Swelling: Edema in the legs, ankles, or around the eyes due to fluid retention.
- Fatigue: Feeling tired or weak.
- Nausea and Vomiting: Gastrointestinal symptoms due to toxin buildup.
- Confusion: Altered mental state or cognitive changes.
- Shortness of Breath: Due to fluid accumulation in the lungs (pulmonary edema).
- Chest Pain: In severe cases, related to fluid overload or associated conditions.

Diagnosis

Diagnosis involves a combination of clinical evaluation, laboratory tests, and imaging studies:

1. Clinical Evaluation:
- Assessment of medical history, symptoms, and physical examination.

2. Laboratory Tests:
- Serum Creatinine and Urea: Elevated levels indicate impaired kidney function.
- Electrolytes: Imbalances in sodium, potassium, and calcium levels.
- Urinalysis: To check for abnormalities such as protein, blood, or casts.
- Fractional Excretion of Sodium (FENa): Helps differentiate between prerenal and intrinsic causes of AKI.

3. Imaging Studies:
- Ultrasound: To assess kidney size, structure, and to rule out obstruction.
- CT Scan: May be used to identify structural abnormalities or obstructions, though with caution in patients with contrast-induced nephropathy.
- MRI: In specific cases, to visualize kidney tissue and function.

4. Additional Tests:
- Kidney Biopsy: In certain cases to diagnose specific types of kidney damage, especially if the cause is unclear.

Treatment Options

Management of AKI focuses on treating the underlying cause, supporting kidney function, and managing complications:

1. Prerenal AKI:
- Fluid Resuscitation: Administering intravenous fluids to restore blood volume and improve kidney perfusion.
- Medications: To address underlying conditions such as heart failure or low blood pressure.

2. Intrarenal AKI:
- Discontinuation of Nephrotoxic Agents: Stopping or adjusting medications that may have caused the injury.
- Treatment of Underlying Conditions: Managing infections, inflammation, or other contributing factors.
- Supportive Care: Monitoring and managing electrolyte imbalances and fluid status.

3. Postrenal AKI:
- Relief of Obstruction: Using procedures to relieve urinary tract obstructions, such as catheterization, ureteral stenting, or surgery.
- Management of Symptoms: Including pain control and supportive care to prevent further complications.

4. Dialysis:
- Initiation of Dialysis: In cases of severe AKI with persistent symptoms or complications (e.g., significant fluid overload, severe electrolyte imbalances, or toxins that cannot be removed).

5. Monitoring and Follow-Up:
- Regular Monitoring: To assess kidney function and adjust treatment as needed.
- Long-Term Management: Including managing chronic conditions and preventing recurrence.

Prognosis

The prognosis of AKI depends on its severity, the underlying cause, and the promptness of treatment. Many patients recover kidney function with appropriate management, but some may experience long-term kidney impairment or progress to chronic kidney disease. Early detection and intervention are key to improving outcomes and minimizing potential complications.

Acute Kidney Injury Epidemiological Insights
The United States contributed to the largest incident population of Acute Kidney Injury, accounting for ~ 34% of the 7MM in 2021, asserts DelveInsight.
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Acute Kidney Injury Treatment Market
Acute Kidney Injury pipeline with a novel mechanism of action and increasing incidence are major market drivers of the AKI market. Additionally, the AKI pipeline is also expected to change the current dynamics of the market, which presently comprises biologics and molecules with new mechanisms of action.
Currently, there are no targeted pharmacotherapies approved for the treatment of AKI. At present, the therapeutic market size of AKI is mainly dominated by the use of Renal Replacement Therapy (RRT) and off-label drugs, which include various classes such as ACE inhibitors, Angiotensin II-Receptor Blockers (ARBs), Diuretics, and Non-Steroidal Anti-Inflammatory Drugs (NSAIDs).
Promising Therapies in the Acute Kidney Injury Pipeline
SB-101
RMC-035 (ROSgard)
OCE-205
RBT-1
And others
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Leading Companies Working in the Acute Kidney Injury Market
Sentien Biotechnologies
Guard Therapeutics
Ocelot Bio
Renibus Therapeutics
And others
To understand key companies related to the Acute Kidney Injury Market, get a snapshot of the Acute Kidney Injury Regulatory and Patent Analysis @ https://www.delveinsight.com/sample-request/acute-kidney-injury-aki-market?utm_source=openpr&utm_medium=pressrelease&utm_campaign=kpr

Scope of the Acute Kidney Injury Market Report
Study Period: 2020-2034
Coverage: 7MM [The United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom), Japan]
Key Acute Kidney Injury Companies: Sentien Biotechnologies, Guard Therapeutics, Ocelot Bio, Renibus Therapeutics, and others
Key Acute Kidney Injury Pipeline Therapies: SB-101, RMC-035 (ROSgard), OCE-205, RBT-1, and others
Therapeutic Assessment: Acute Kidney Injury current marketed and emerging therapies
Acute Kidney Injury Market Dynamics: Acute Kidney Injury market drivers and barriers
Competitive Intelligence Analysis: SWOT analysis, PESTLE analysis, Porter's five forces, BCG Matrix, Market entry strategies
Unmet Needs, KOL's views, Analyst's views, Acute Kidney Injury Market Access and Reimbursement
Table of Contents
1. Acute Kidney Injury Market Key Insights
2. Acute Kidney Injury Market Report Introduction
3. Acute Kidney Injury Market Overview at a Glance
4. Acute Kidney Injury Market Executive Summary
5. Disease Background and Overview
6. Acute Kidney Injury Treatment and Management
7. Acute Kidney Injury Epidemiology and Patient Population
8. Patient Journey
9. Acute Kidney Injury Emerging Drugs
10. 7MM Acute Kidney Injury Market Analysis
11. Acute Kidney Injury Market Outlook
12. Potential of Current and Emerging Therapies
13. KOL Views
14. Acute Kidney Injury Market Drivers
15. Acute Kidney Injury Market Barriers
16. Unmet Needs
17. SWOT Analysis
18. Appendix
19. DelveInsight Capabilities
20. Disclaimer
21. About DelveInsight

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