Desmoid Tumors Clinical Trials | A Drug Pipeline Analysis Report 2024 | SpringWorks Therapeutics, Iterion Therapeutics, and others

United States, Nevada, Las Vegas, DelveInsight's 'Desmoid Tumors Pipeline Insight 2024' report provides comprehensive global coverage of available, marketed, and pipeline Desmoid Tumors therapies in various stages of clinical development, major pharmaceutical companies are working to advance the pipeline space and future growth potential of the Desmoid Tumors pipeline domain.
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Key Takeaways from the Desmoid Tumors Pipeline Report
Over 12+ Desmoid Tumors pipeline therapies are in various stages of development, and their anticipated acceptance in the Desmoid Tumors market would significantly increase market revenue.
Leading Desmoid Tumors companies developing novel drug candidates to improve the Desmoid Tumors treatment landscape include SpringWorks Therapeutics, Iterion Therapeutics, and others.
Promising Desmoid Tumors pipeline therapies in various stages of development include Nirogacestat, Tegavivint, and others.
Desmoid Tumors Overview
Desmoid tumors, also known as aggressive fibromatosis or desmoid-type fibromatosis, are rare, locally invasive tumors that arise from connective tissue cells, typically in the muscles, fascia (connective tissue surrounding muscles), or other soft tissues. Here's an overview covering their causes, signs and symptoms, diagnosis, and treatment options:

Desmoid Tumors Causes:
The exact cause of desmoid tumors is not fully understood. They are considered to be neoplastic, meaning they involve abnormal cell growth, but they are not malignant (cancerous) in the traditional sense because they do not metastasize to distant organs. Possible contributing factors include:

1. Genetic mutations: Some desmoid tumors are associated with genetic mutations, particularly mutations in the APC gene (adenomatous polyposis coli), which is also linked to familial adenomatous polyposis (FAP).

2. Hormonal factors: Estrogen may play a role in the growth of desmoid tumors, as they are more common in women of childbearing age and can grow during pregnancy.

3. Previous trauma or surgery: Desmoid tumors can sometimes arise at the site of previous surgery, injury, or trauma.

Desmoid Tumors Signs and Symptoms:
1. Painless swelling or mass: The most common initial symptom is a firm, painless swelling or mass in the affected area, often in the abdominal wall, shoulder, thigh, or chest wall.

2. Limited range of motion: If located near joints or muscles, desmoid tumors can cause stiffness or restriction in movement.

3. Compression symptoms: Large tumors may compress nearby structures, leading to symptoms such as pain, bowel obstruction (if in the abdomen), or difficulty breathing (if in the chest).

Desmoid Tumors Diagnosis:
1. Imaging tests: CT scan or MRI can help visualize the size, location, and extent of the tumor.

2. Biopsy: A biopsy is necessary to confirm the diagnosis, usually obtained through a needle biopsy or surgical biopsy. The tissue is examined under a microscope by a pathologist to determine if it is a desmoid tumor.

3. Genetic testing: In cases where there is suspicion of familial adenomatous polyposis (FAP), genetic testing may be recommended to check for mutations in the APC gene.

Desmoid Tumors Treatment Options:
The management of desmoid tumors is challenging due to their unpredictable growth and tendency to recur. Treatment decisions depend on factors such as tumor location, size, symptoms, and patient preferences. Treatment options include:

1. Active surveillance: In some cases, especially if the tumor is small, asymptomatic, and in a non-critical location, the approach may be watchful waiting with regular monitoring.

2. Surgery: Surgical removal of the tumor may be considered if feasible without causing significant functional impairment or if the tumor is causing severe symptoms.

3. Radiation therapy: Radiation may be used for tumors that are difficult to remove surgically or recur after surgery. However, radiation therapy carries risks and may not be suitable for all patients.

4. Systemic therapy:
- Nonsteroidal anti-inflammatory drugs (NSAIDs): Some patients may benefit from NSAIDs like sulindac.
- Hormonal therapy: Medications that interfere with estrogen production or activity (such as tamoxifen or aromatase inhibitors) may be used, particularly for tumors influenced by hormonal factors.

5. Targeted therapy: Recent advancements have shown promise with targeted therapies that aim to inhibit specific pathways involved in tumor growth, such as tyrosine kinase inhibitors (e.g., imatinib) or beta-catenin inhibitors.

6. Clinical trials: Participation in clinical trials investigating new treatment approaches may be considered, especially for recurrent or unresectable tumors.

Desmoid Tumors Market Outlook:
The prognosis for desmoid tumors varies widely. Some tumors may remain stable or regress spontaneously without treatment, while others may grow aggressively or recur despite treatment. Close monitoring and a multidisciplinary approach involving oncologists, surgeons, and other specialists are crucial for managing desmoid tumors effectively and improving outcomes for patients.
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Desmoid Tumors Pipeline Analysis: Drug Profile
Nirogacestat: SpringWorks Therapeutics
Nirogacestat is an oral, selective, small molecule, gamma secretase inhibitor. It is currently in Phase 3 clinical development for patients with desmoid tumors. The U.S. FDA has granted nirogacestat Orphan Drug Designation for the treatment of desmoid tumors and Fast Track and Breakthrough Therapy Designations for the treatment of adult patients with progressive, unresectable, recurrent or refractory desmoid tumors or deep fibromatosis.
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Desmoid Tumors Key Companies
SpringWorks Therapeutics
Iterion Therapeutics
Desmoid Tumors Pipeline Therapies
Nirogacestat
Tegavivint
Desmoid Tumors Pipeline Therapeutics Assessment
By development stage
By product type
By route of administration
By molecule type
By MOA type
Scope of the Desmoid Tumors Pipeline Report
Coverage: Global
Key Desmoid Tumors Companies: SpringWorks Therapeutics, Iterion Therapeutics, and others
Key Desmoid Tumors Pipeline Therapies: Nirogacestat, Tegavivint, and others
Find out more about the Desmoid Tumors treatment options in development @ https://www.delveinsight.com/sample-request/desmoid-tumors-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=kpr

Table of Contents
1. Introduction
2. Executive Summary
3. Overview
4. Pipeline Therapeutics
5. Late-Stage Products (Phase III)
6. Mid-Stage Products (Phase II)
7. Early Stage Products (Phase I/II)
8. Preclinical Stage Products
9. Discovery Stage Products
10. Therapeutic Assessment
11. Inactive Products
12. Collaborations Assessment- Licensing / Partnering / Funding
13. Unmet Needs
14. Market Drivers and Barriers
15. Appendix
16. About DelveInsight

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