Diabetic Peripheral Neuropathy Clinical Trials, Key Companies, Emerging Therapies | A Drug Pipeline Analysis Report 2024 | CSPC ZhongQi Pharmaceutical Technology Co., Ltd., Helixmith, Aptinyx, Lexicon Pharmaceuticals

DelveInsight's 'Diabetic Peripheral Neuropathy Pipeline Insight 2024' report provides comprehensive global coverage of available, marketed, and pipeline Diabetic Peripheral Neuropathy therapies in various stages of clinical development, major pharmaceutical companies are working to advance the pipeline space and future growth potential of the Diabetic Peripheral Neuropathy pipeline domain.
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Key Takeaways from the Diabetic Peripheral Neuropathy Pipeline Report
Over 20+ Diabetic Peripheral Neuropathy pipeline therapies are in various stages of development, and their anticipated acceptance in the Diabetic Peripheral Neuropathy market would significantly increase market revenue.
Leading Diabetic Peripheral Neuropathy companies developing novel drug candidates to improve the Diabetic Peripheral Neuropathy treatment landscape include CSPC ZhongQi Pharmaceutical Technology Co., Ltd., Helixmith, Aptinyx, Lexicon Pharmaceuticals, and others.
Promising Diabetic Peripheral Neuropathy pipeline therapies in various stages of development include FE-SYHA1402, VM202, NYX-2925, LX9211, and others.
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Diabetic Peripheral Neuropathy Overview

Diabetic Peripheral Neuropathy (DPN) is a type of nerve damage that occurs as a complication of diabetes mellitus. It affects the peripheral nerves, which are responsible for transmitting sensory and motor signals between the body and the central nervous system. DPN is one of the most common complications of diabetes, particularly in individuals with poorly controlled blood sugar levels over an extended period.

Diabetic Peripheral Neuropathy Signs and Symptoms:

The signs and symptoms of diabetic peripheral neuropathy can vary depending on the type and location of nerves affected. They may include:

1. Sensory Symptoms:
- Numbness or reduced sensation: Especially in the feet, legs, hands, and arms.
- Tingling (paresthesia) or burning sensation: Often described as pins and needles.
- Heightened sensitivity to touch: Some individuals may experience pain from stimuli that are not normally painful (allodynia).
- Loss of coordination and balance: Difficulty walking or performing fine motor tasks.

2. Motor Symptoms:
- Muscle weakness: Especially in the legs and feet, leading to difficulty with walking or standing.
- Muscle cramps or spasms: Involuntary muscle contractions may occur.

3. Autonomic Symptoms:
- Changes in sweating: Excessive sweating (hyperhidrosis) or reduced sweating (hypohidrosis).
- Blood pressure abnormalities: Orthostatic hypotension (low blood pressure upon standing).
- Gastrointestinal symptoms: Such as constipation, diarrhea, or gastroparesis (delayed stomach emptying).

4. Foot Complications:
- Foot ulcers: Due to decreased sensation and impaired wound healing.
- Charcot's joint: Weakening of the bones in the foot leading to joint deformities.

Diabetic Peripheral Neuropathy Causes:

The exact cause of diabetic peripheral neuropathy is not fully understood, but several factors contribute to its development:

1. High blood sugar levels (hyperglycemia): Prolonged exposure to elevated glucose levels damages nerve fibers and impairs nerve function.

2. Advanced glycation end products (AGEs): Excess glucose can form AGEs, which accumulate in nerve tissues and contribute to nerve damage.

3. Microvascular complications: Reduced blood flow to nerves due to damage to small blood vessels (microangiopathy) can lead to nerve ischemia and dysfunction.

4. Inflammation: Chronic inflammation associated with diabetes may contribute to nerve damage.

Diabetic Peripheral Neuropathy Diagnosis:

Diagnosing diabetic peripheral neuropathy involves a comprehensive evaluation by a healthcare provider, including:

1. Medical History and Physical Examination:
- Assessment of symptoms, duration, and progression of neuropathy.
- Neurological examination to evaluate sensory, motor, and autonomic function.

2. Electrophysiological Studies:
- Nerve conduction studies (NCS): Measures the speed and strength of electrical signals transmitted through nerves.
- Electromyography (EMG): Measures electrical activity in muscles to assess nerve-muscle function.

3. Quantitative Sensory Testing (QST):
- Evaluates sensory thresholds to detect abnormalities in sensory perception.

4. Blood Tests:
- HbA1c: Measures average blood sugar levels over the past 2-3 months to assess diabetes control.
- Comprehensive metabolic panel: To assess kidney function, liver function, and electrolyte levels.

Diabetic Peripheral Neuropathy Treatment Options:

Treatment for diabetic peripheral neuropathy focuses on managing symptoms, slowing disease progression, and preventing complications:

1. Blood Sugar Control:
- Optimal glycemic control through diet, exercise, and medications (insulin or oral antidiabetic agents) to prevent further nerve damage.

2. Medications:
- Pain management: Analgesic medications such as acetaminophen, nonsteroidal anti-inflammatory drugs (NSAIDs), or opioids may be used for pain relief.
- Antidepressants: Tricyclic antidepressants (e.g., amitriptyline) or selective serotonin and norepinephrine reuptake inhibitors (SSNRIs) such as duloxetine may help relieve neuropathic pain.
- Anticonvulsants: Medications like gabapentin or pregabalin are effective for neuropathic pain management.

3. Physical Therapy:
- Exercises to improve strength, flexibility, and balance.
- Techniques to improve gait and prevent falls.

4. Foot Care:
- Regular foot examinations to detect changes in sensation or skin integrity.
- Proper foot hygiene and moisturizing to prevent dry skin and cracking.
- Wearing appropriate footwear to reduce the risk of foot ulcers.

5. Alternative Therapies:
- Transcutaneous electrical nerve stimulation (TENS): Uses electrical currents to relieve pain.
- Acupuncture: Some individuals find relief from neuropathic pain with acupuncture treatments.

6. Management of Complications:
- Regular monitoring for foot ulcers, infections, and other complications.
- Prompt treatment of complications to prevent progression and improve outcomes.

Diabetic Peripheral Neuropathy Market Outlook:

The prognosis for diabetic peripheral neuropathy depends on early diagnosis, effective management of diabetes, and prompt intervention to prevent complications such as foot ulcers and infections. While symptoms may be managed with medications and therapies, diabetic peripheral neuropathy is often a chronic condition that requires ongoing monitoring and treatment to maintain quality of life and prevent disability.

Diabetic Peripheral Neuropathy Pipeline Analysis: Drug Profile
FE-SYHA1402: CSPC ZhongQi Pharmaceutical Technology Co., Ltd.
ZhongQi Pharmaceutical Technology is conducting a multiple doses study to evaluate the safety, tolerability, pharmacokinetics (including food effect) of SYHA1402 in healthy subjects. This study consists of two parts: The objective of the food effect study (Part 1) is to investigate the effect of food on the pharmacokinetic profiles of SYHA1402 tablets under fed and fasted conditions following the oral administration of SYHA1402. The primary objective of the multiple doses study (Part 2) is to investigate safety, tolerability and Pharmacokinetics of SYHA1402 in healthy subjects following oral administration of Multiple rising doses. Secondary objectives are the exploration of pharmacokinetics (PK) following multiple oral doses.
Discover more about the emerging Diabetic Peripheral Neuropathy drugs @ https://www.delveinsight.com/sample-request/diabetic-peripheral-neuropathy-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=kpr

Diabetic Peripheral Neuropathy Key Companies
CSPC ZhongQi Pharmaceutical Technology Co., Ltd.
Helixmith
Aptinyx
Lexicon Pharmaceuticals
Diabetic Peripheral Neuropathy Pipeline Therapies
FE-SYHA1402
VM202
NYX-2925
LX9211
Diabetic Peripheral Neuropathy Pipeline Therapeutics Assessment
By development stage
By product type
By route of administration
By molecule type
By MOA type
Scope of the Diabetic Peripheral Neuropathy Pipeline Report
Coverage: Global
Key Diabetic Peripheral Neuropathy Companies: CSPC ZhongQi Pharmaceutical Technology Co., Ltd., Helixmith, Aptinyx, Lexicon Pharmaceuticals, and others
Key Diabetic Peripheral Neuropathy Pipeline Therapies: FE-SYHA1402, VM202, NYX-2925, LX9211, and others
Find out more about the Diabetic Peripheral Neuropathy treatment options in development @ https://www.delveinsight.com/sample-request/diabetic-peripheral-neuropathy-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=kpr

Table of Contents
1. Introduction
2. Executive Summary
3. Overview
4. Pipeline Therapeutics
5. Late-Stage Products (Phase III)
6. Mid-Stage Products (Phase II)
7. Early Stage Products (Phase I/II)
8. Preclinical Stage Products
9. Discovery Stage Products
10. Therapeutic Assessment
11. Inactive Products
12. Collaborations Assessment- Licensing / Partnering / Funding
13. Unmet Needs
14. Market Drivers and Barriers
15. Appendix
16. About DelveInsight
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