Sciatica Clinical Trials | A Drug Pipeline Analysis Report 2024 | Sollis Therapeutics, Scilex Holding

United States, Nevada, Las Vegas, DelveInsight's 'Sciatica Pipeline Insight 2024' report provides comprehensive global coverage of available, marketed, and pipeline Sciatica therapies in various stages of clinical development, major pharmaceutical companies are working to advance the pipeline space and future growth potential of the Sciatica pipeline domain.
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Key Takeaways from the Sciatica Pipeline Report
Over 5+ Sciatica pipeline therapies are in various stages of development, and their anticipated acceptance in the Sciatica market would significantly increase market revenue.
Leading Sciatica companies developing novel drug candidates to improve the Sciatica treatment landscape include Sollis Therapeutics, Scilex Holding, and others.
Promising Sciatica pipeline therapies in various stages of development include STX-015, SP-102, and others.
Sciatica Overview

Sciatica refers to pain that radiates along the path of the sciatic nerve, which branches from your lower back through your hips and buttocks and down each leg. It usually affects one side of the body. Sciatica is not a medical condition itself but rather a symptom of an underlying problem, such as a herniated disc pressing on the nerve roots that lead to the sciatic nerve.

Sciatica Causes:

The most common cause of sciatica is a herniated disc in the lumbar spine (lower back) that compresses or irritates the nerve roots. Other causes may include:

1. Degenerative disc disease: Wear and tear on the discs that cushion the vertebrae.

2. Spinal stenosis: Narrowing of the spinal canal, which can compress the nerves.

3. Spondylolisthesis: A condition where one vertebra slips forward over another.

4. Piriformis syndrome: Irritation or compression of the sciatic nerve by the piriformis muscle in the buttocks.

Sciatica Signs and Symptoms:

The hallmark symptom of sciatica is pain that radiates from the lower back or buttock down the back of one thigh and into the leg. The pain can vary widely, from a mild ache to a sharp, burning sensation or excruciating discomfort. Other common symptoms include:

1. Pain that worsens with sitting: Particularly if prolonged sitting increases pressure on the sciatic nerve.

2. Numbness or tingling: Along the path of the sciatic nerve, often extending into the toes.

3. Weakness: Difficulty moving the leg or foot, especially when trying to lift the heel off the ground or walk on toes.

Sciatica Diagnosis:

1. Medical History and Physical Examination: Your doctor will ask about your symptoms, conduct a physical exam to check your reflexes, muscle strength, and sensation in affected areas.

2. Imaging Tests:
- MRI (Magnetic Resonance Imaging): Provides detailed images of the spine and can show herniated discs, spinal stenosis, or other structural problems.
- CT (Computed Tomography) Scan: Sometimes used to get a more detailed view of the spine and nerve roots.
- X-rays: To rule out other causes of back pain, such as fractures or arthritis.

3. Electromyography (EMG) and Nerve Conduction Studies: May be performed to assess nerve function and determine if there is any nerve damage.

Sciatica Treatment Options:

Treatment for sciatica depends on the underlying cause and severity of symptoms. Options include:

1. Medications:
- Over-the-counter pain relievers: Such as ibuprofen or acetaminophen to reduce pain and inflammation.
- Muscle relaxants: To relieve muscle spasms.
- Prescription medications: Such as corticosteroids or stronger pain medications in severe cases.

2. Physical Therapy:
- Specific exercises and stretches to strengthen the muscles supporting the back, improve flexibility, and reduce pressure on the sciatic nerve.

3. Injection Therapy:
- Epidural steroid injections: To reduce inflammation and relieve pain by delivering steroids directly into the affected area of the spine.
- Trigger point injections: To alleviate pain caused by muscle spasms, particularly in piriformis syndrome.

4. Alternative Therapies:
- Chiropractic adjustments: Manipulation of the spine to improve alignment and reduce pressure on the sciatic nerve.
- Acupuncture: Fine needles inserted into specific points to alleviate pain and improve nerve function.

5. Surgery:
- Diskectomy or laminectomy: Surgical procedures to remove part of a herniated disk or bone spur pressing on the nerve root.
- Microdiscectomy: Minimally invasive surgery to remove a small portion of a herniated disk.

6. Self-care measures:
- Applying hot or cold packs: To alleviate pain and reduce inflammation.
- Maintaining good posture: Especially when sitting, to avoid putting pressure on the sciatic nerve.
- Avoiding prolonged sitting or standing: Alternating positions and taking breaks to reduce stress on the spine.

Sciatica Market Outlook:

Most cases of sciatica resolve with conservative treatments like medications, physical therapy, and self-care measures. Surgery is typically considered only when symptoms persist despite conservative treatment or if there is severe nerve compression requiring immediate intervention. Early diagnosis and appropriate management can help alleviate symptoms and prevent recurrence of sciatica.

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Sciatica Pipeline Analysis: Drug Profile
STX-015: Sollis Therapeutics
STX-015 is an Alpha 2 adrenergic receptor agonist being developed by Sollis Therapeutics for the treatment of sciatica. Currently, it is in Phase III stage of clinical trial evaluation.
Discover more about the emerging Sciatica drugs @ https://www.delveinsight.com/sample-request/sciatica-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=kpr

Sciatica Key Companies
Sollis Therapeutics
Scilex Holding
Sciatica Pipeline Therapies
STX-015
SP-102
Sciatica Pipeline Therapeutics Assessment
By development stage
By product type
By route of administration
By molecule type
By MOA type
Scope of the Sciatica Pipeline Report
Coverage: Global
Key Sciatica Companies: Sollis Therapeutics, Scilex Holding, and others
Key Sciatica Pipeline Therapies: STX-015, SP-102, and others
Find out more about the Sciatica treatment options in development @ https://www.delveinsight.com/sample-request/sciatica-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=kpr

Table of Contents
1. Introduction
2. Executive Summary
3. Overview
4. Pipeline Therapeutics
5. Late-Stage Products (Phase III)
6. Mid-Stage Products (Phase II)
7. Early Stage Products (Phase I/II)
8. Preclinical Stage Products
9. Discovery Stage Products
10. Therapeutic Assessment
11. Inactive Products
12. Collaborations Assessment- Licensing / Partnering / Funding
13. Unmet Needs
14. Market Drivers and Barriers
15. Appendix
16. About DelveInsight

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