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hERG Screening Market Poised to Reach USD 8.2 Bn by 2034 with a 12.6% CAGR | Exclusive Report by Transparency Market Research, Inc.

07-04-2024 04:24 PM CET | Health & Medicine

Press release from: Transparency Market Research

hERG Screening Market

hERG Screening Market

The hERG screening market plays a crucial role in pharmaceutical research and development, particularly in ensuring drug safety by assessing potential risks associated with cardiac ion channel interactions. As advancements in medical science propel the pharmaceutical industry forward, the demand for reliable screening methods like hERG continues to grow.

hERG, short for human Ether-à-go-go-Related Gene, refers to a gene encoding a protein responsible for the potassium ion channel in the heart. Screening this gene and its variants, such as mutant KCNH2, is vital in identifying potential risks of drugs causing cardiac arrhythmias. The market for hERG screening was valued at US$ 2.2 billion in 2023 and is projected to expand significantly, reaching US$ 8.2 billion by 2034, growing at a compound annual growth rate (CAGR) of 12.6%.

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Market Segmentation

By Type: Gene KCNH2 and Mutant KCNH2

Gene KCNH2 screening focuses on assessing the function of the normal hERG channel, crucial for understanding baseline cardiac safety. On the other hand, mutant KCNH2 screening examines how mutations in the gene may affect ion channel function, providing insights into potential drug-induced adverse effects.

By Ion Channel: Voltage-Gated and Ligand-Gated

Voltage-gated ion channels (VGICs) are critical for regulating the flow of ions across cellular membranes, including potassium ions crucial for cardiac function. Ligand-gated ion channels (LGICs), responsive to neurotransmitters or drugs, also influence cellular excitability and are important in drug safety assessments.

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Key Drivers of Market Growth

The hERG screening market's growth is driven by stringent regulatory standards mandating thorough cardiac safety assessments during drug development. Pharmaceutical companies increasingly rely on hERG screening to meet these regulatory requirements, ensuring new drugs do not pose undue risks to patients. Moreover, the rise in drug development activities globally, fueled by healthcare advancements and the need for novel therapies, further propels market expansion.

Challenges and Opportunities

Technological advancements in screening methodologies present significant opportunities in the hERG screening market. Innovations such as automated patch clamp systems and high-throughput screening techniques improve screening accuracy and efficiency, expediting drug development timelines. However, the complexity of accurately predicting drug-induced cardiac risks remains a challenge, requiring continuous innovation and collaboration across disciplines.

Regional Insights

In North America, the hERG screening market dominates due to advanced healthcare infrastructure, robust research capabilities, and stringent regulatory oversight. Europe and Asia-Pacific regions are also witnessing substantial growth, driven by increasing pharmaceutical investments and regulatory reforms aimed at enhancing drug safety standards.

Future Trends

The integration of artificial intelligence (AI) and machine learning (ML) into hERG screening processes is expected to revolutionize drug safety assessments. AI-driven algorithms can analyze vast datasets more efficiently, predicting potential cardiac risks with greater accuracy. Additionally, the shift towards personalized medicine approaches tailors drug therapies to individual patient profiles, influencing how hERG screening adapts to accommodate personalized treatment paradigms.

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About Us Transparency Market Research

Transparency Market Research, a global market research company registered at Wilmington, Delaware, United States, provides custom research and consulting services. The firm scrutinizes factors shaping the dynamics of demand in various markets. The insights and perspectives on the markets evaluate opportunities in various segments. The opportunities in the segments based on source, application, demographics, sales channel, and end-use are analysed, which will determine growth in the markets over the next decade.

Our exclusive blend of quantitative forecasting and trends analysis provides forward-looking insights for thousands of decision-makers, made possible by experienced teams of Analysts, Researchers, and Consultants. The proprietary data sources and various tools & techniques we use always reflect the latest trends and information. With a broad research and analysis capability, Transparency Market Research employs rigorous primary and secondary research techniques in all of its business reports.

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