Actinium Pharmaceuticals (ATNM) Reveals Promising Results from SIERRA Trial at EHA Congress

Median Overall Survival of 5.49 months observed in patients with a TP53 mutation receiving an Iomab-B led allogeneic bone marrow transplant compared to 1.66 months in patients that did not receive Iomab-B (hazard ratio=0.23, p=0.0002) in the Phase 3 SIERRA Trial - Long-term efficacy results in patients with active relapsed or refractory acute myeloid leukemia also observed in the SIERRA trial
DelveInsight's analysts estimate that relapsed/refractory acute myeloid leukemia market is poised to show significant growth, mainly attributed to recent drug approvals, increasing incidence, and anticipated launch of novel therapies during the forecast period (2023-2032).

Time to pull up Actinium Pharmaceuticals, Inc. (NYSE AMERICAN: ATNM), on your screens now. Actinium Pharmaceuticals is dedicated to advancing targeted radiotherapies to significantly enhance survival outcomes for patients who have exhausted conventional cancer treatments. Among its leading candidates, Iomab-B is set to revolutionize the bone marrow transplant process for blood cancer treatment, while Actimab-A continues to show potential in pivotal trials for r/r AML. With over 230 patents in its portfolio, Actinium is also at the forefront of developing next-generation conditioning agents like Iomab-ACT to augment outcomes in cell and gene therapies, marking it as a leader in the oncology space.

Actinium Pharmaceuticals, Inc. (NYSE AMERICAN: ATNM), a pioneer in the development of Antibody Radiation Conjugates (ARCs) and other targeted radiotherapies, recently shared significant findings from its Phase 3 SIERRA trial at the 2024 European Hematology Association (EHA) Hybrid Congress in Madrid, Spain. This key trial focused on Iomab-B, a promising therapeutic agent for patients with relapsed or refractory acute myeloid leukemia (r/r AML).

The SIERRA trial, which targeted an older patient demographic (55 years and older) suffering from active r/r AML, enrolled 153 participants and provided critical insights into the efficacy of Iomab-B led bone marrow transplants (BMT). Notably, the trial's primary endpoint of durable complete remission was achieved exclusively by patients receiving Iomab-B led BMT, showcasing impressive survival rates: 92% at one year and 69% at two years, with significantly higher event-free survival.

Key Outcomes for Patients with TP53 Mutation

During the congress, Dr. Hannah Choe from Ohio State University, who is also a SIERRA trial investigator, presented compelling data regarding patients with the TP53 mutation, a genetic alteration associated with poor prognosis and limited treatment options. The data highlighted:

- A stark contrast in median Overall Survival (OS) between patients with TP53 mutations receiving Iomab-B (5.49 months) and those who did not (1.66 months), emphasizing Iomab-B's efficacy (hazard ratio=0.23, p=0.0002).

- Iomab-B's ability to improve outcomes even in TP53 negative patients, showcasing its potential to overcome detrimental genetic profiles.

Long-Term Efficacy Results

Further data presented revealed that 75% of patients on the Iomab-B arm achieved complete remission, compared to just 6.3% in the control arm. The durability of these remissions was underscored by a 22% durable complete remission rate in the Iomab-B arm, a significant statistic given the zero percent in the control group. Patients achieving durable complete remission also demonstrated remarkable survival rates, not reaching median overall survival yet.

Iomab-B was noted for its favorable safety profile, significantly reducing the risks of sepsis and mucositis compared to traditional care, further advocating its role as a safer and more effective treatment modality.

ATNM has a 52 week high of $10.24. According to TipRanks.com, ATNM has average price target of $29.40 suggesting a significant upside potential from the current levels.

Other biotech stocks to keep on top of radar include Biomarin Pharmaceuticals Inc. (NASDAQ: BMRN), Halozyme Therapeutics, Inc. (NASDAQ: HALO), Incyte Corporation (NASDAQ: INCY), Exelixis, Inc. (NASDAQ: EXEL), Mimedx Group, Inc. (NASDAQ: MDXG), Genmab AS (NASDAQ: GMAB), Vertex Pharmaceuticals Inc. (NASDAQ: VRTX), Bio-Techne Corp (NASDAQ: TECH), Jazz Pharmaceuticals PLC (NASDAQ: JAZZ).

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Sources:

https://www.tipranks.com/stocks/atnm

https://finance.yahoo.com/news/actinium-highlights-oral-presentation-eha-123000963.html

https://www.prnewswire.com/news-releases/relapsedrefractory-acute-myeloid-leukemia-market-growing-rapidly-estimates-delveinsight--key-companies-active-in-the-domain---pfizer-merck-novartis-astellas-amgen-janssen-kartos-cullinan-oncology-meryx-301833050.html

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