Endometriosis Market Outlook Report 2034 | AbbVie, Neurocrine Biosciences, ObsEva, Kissei Pharmaceuticals, SWK, Enteris BioPharma, Bayer, Hope Medicine, Tiumbio, Organon

DelveInsight's "Endometriosis Market Insights, Epidemiology, and Market Forecast-2032" report delivers an in-depth understanding of Endometriosis, historical and forecasted epidemiology as well as the Endometriosis market trends in the United States, EU5 (Germany, Spain, Italy, France, and United Kingdom), and Japan.

The Endometriosis market report provides current treatment practices, emerging drugs, the market share of the individual therapies, and the current and forecasted Endometriosis market size from 2019 to 2032, segmented by seven major markets. The Report also covers current Endometriosis treatment practice/algorithm, market drivers, market barriers, and unmet medical needs to curate the best opportunities and assesses the underlying potential of the Endometriosis market.

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Key highlights from the Endometriosis Market Report:

In 2023, the diagnosed prevalent cases of endometriosis in the 7MM were ~10,770,000 cases.
Based on severity, moderate cases accounted for the highest share, i.e. ~40% in the 7MM, followed by severe and mild cases, respectively in 2023.
The total market size of endometriosis in the 7MM was USD 2,300 million in 2023 and is expected to grow significantly over the forecast period owing to launch of new therapies.
Despite developing novel treatments, the present pharmacological landscape has several drawbacks. Hormone therapy can affect the ability to get pregnant, so it may not be right for everyone. NSAIDs are mostly used as off-label for pain management of endometriosis, but chronic uses may cause kidney damage. Moreover, opioids have high addiction potential.
Various new therapies are in development with a focus on mentioned limitations of the currently approved drugs. Some of the most prominent ones include OG-6219 (Organon), linzagolix (ObsEva SA), HMI-115 (Hope Medicine), VML-0501 (Viramal), and others.
Among emerging therapies, OG-6219 is expected to garner the largest market share by 2034.
Growth of the endometriosis market is expected to be mainly driven by the entry of novel therapies with better clinical profiles, an upsurge in research and development, and an enriched understanding of the disease.
The rise in market size during the study period (2020─2034) is mainly driven by current treatment options like NSAIDs/opioids and the introduction of pipeline candidates OG-6219, and elagolix + estradiol + norethindrone during the forecast period.
In 2023, the diagnosed prevalent cases of endometriosis in the 7MM were ~10,800,000. In the 7MM, the highest number of diagnosed prevalent cases of endometriosis was observed in the US.
In the 7MM, Moderate cases garner the highest share in diagnosed prevalent cases by pain severity in 2023.
Endometriosis is most common among 18-29 years female population which represented ~ 40% of all prevalent cases in the 7MM.
Total treated cases of endometriosis amounted to ~2,900,000 in the US, followed by the UK and France, respectively in 2023.

Endometriosis Overview

Endometriosis is a chronic medical condition where tissue similar to the lining inside the uterus, known as endometrial tissue, grows outside the uterus. This condition commonly involves the ovaries, fallopian tubes, and the tissue lining the pelvis. In rare cases, it can spread beyond the pelvic organs. Endometriosis can cause pain, sometimes severe, and may lead to fertility problems.

Endometriosis Causes

The exact cause of endometriosis is not well understood, but several theories exist, including:

2. Embryonic Cell Transformation: Hormones such as estrogen may transform embryonic cells (cells in the earliest stages of development) into endometrial-like cell implants during puberty.

3. Surgical Scars Implantation: After a surgery such as a hysterectomy or C-section, endometrial cells may attach to the surgical incision.

4. Immune System Disorders: Problems with the immune system might make the body unable to recognize endometrial-like tissue growing outside the uterus.

5. Genetics: There may be a hereditary component, as endometriosis can run in families.

Endometriosis Signs and Symptoms

The primary symptom of endometriosis is pelvic pain, often associated with menstrual periods. Common signs and symptoms include:

- Painful Periods (Dysmenorrhea): Pelvic pain and cramping may begin before and extend several days into a menstrual period. Pain may also radiate to the lower back and abdomen.
- Pain with Intercourse: Pain during or after sex is common with endometriosis.
- Pain with Bowel Movements or Urination: These symptoms are most likely to occur during a menstrual period.
- Excessive Bleeding: Occasional heavy periods (menorrhagia) or bleeding between periods (menometrorrhagia).
- Infertility: Endometriosis is first diagnosed in some women who are seeking treatment for infertility.
- Other Symptoms: Fatigue, diarrhea, constipation, bloating, and nausea, especially during menstrual periods.

Endometriosis Diagnosis

Diagnosing endometriosis can be challenging due to the similarity of symptoms to other conditions. Common diagnostic steps include:

1. Pelvic Exam: A doctor manually checks areas in the pelvis for abnormalities.
2. Imaging Tests: Ultrasound, MRI, or CT scans can provide detailed images of reproductive organs and identify cysts associated with endometriosis.
3. Laparoscopy: A surgical procedure where a doctor inserts a laparoscope through a small incision in the abdomen to directly visualize the internal organs and obtain tissue samples for biopsy.
4. Biopsy: Taking a tissue sample during laparoscopy to confirm endometriosis through microscopic examination.

Endometriosis Treatment

While there is no cure for endometriosis, treatments are available to manage symptoms and improve quality of life. Options include:

1. Medications:
- Pain Relievers: Over-the-counter NSAIDs like ibuprofen or prescription pain medication.
- Birth control pills, patches, and vaginal rings.
- Gonadotropin-releasing hormone (Gn-RH) agonists and antagonists.
- Progestin therapy (injections, intrauterine devices).
- Aromatase inhibitors.

2. Conservative Surgery: Laparoscopic surgery to remove as much endometriosis as possible while preserving the uterus and ovaries, which can help with pain relief and fertility.

3. Hysterectomy: In severe cases, removal of the uterus (hysterectomy) and possibly the ovaries (oophorectomy) might be considered. This is typically seen as a last resort.

4. Lifestyle and Home Remedies:
- Regular exercise and relaxation techniques.
- Heat application (heating pads or warm baths).
- Dietary changes to manage symptoms (e.g., anti-inflammatory diet).

5. Alternative Therapies: Acupuncture, chiropractic care, and herbal supplements may provide relief for some women, though their efficacy varies.

6. Fertility Treatment: For women facing infertility, assisted reproductive technologies (ART) like in vitro fertilization (IVF) might be recommended.

Endometriosis is a complex condition with a significant impact on quality of life. Early diagnosis and a multidisciplinary approach to treatment can help manage symptoms effectively and improve outcomes for those affected.

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Endometriosis Market

Endometriosis is a condition where endometrial tissue grows outside the uterine cavity, often causing recurrent bleeding due to its hormonal responsiveness. This leads to fibrosis, chronic pelvic pain, and infertility, primarily affecting adolescents and women of reproductive age. Common sites include the ovaries, pelvic peritoneum, uterosacral ligaments, and torus uterinus. Less common locations include the cervix, vagina, round ligaments, ureter, nerves, and even rare extrapelvic sites like the upper abdomen, subphrenic fold, or abdominal wall.

Treatment Approaches

Despite the absence of a cure, treatments for endometriosis aim to manage symptoms, particularly pain and infertility. These include:

1. Drug Therapies:
- Pain Relief: Nonsteroidal anti-inflammatory drugs (NSAIDs).
- Hormonal Treatments: Combined hormonal contraceptives, progestogens, antiprogestogens, gonadotropin-releasing hormone (GnRH) agonists and antagonists.

2. Surgical Interventions:
- Conservative Surgery: Fulguration or excision of endometrial lesions.
- Definitive Surgery: Hysterectomy with or without bilateral salpingo-oophorectomy. Surgery is currently the only treatment option shown to improve fertility rates.

Emerging Treatments

Many new molecules with novel mechanisms are under development, such as:
- LHRH receptor antagonists.
- Gonadotropin-releasing hormone stimulants.
- Prolactin receptor antagonists.

Key players in developing these new treatments include ObsEva SA, Myovant Sciences, Hope Medicine, and Organon. These novel therapies are expected to address the unmet needs in endometriosis treatment, leading to significant improvements in patient outcomes.

Future Outlook

The upcoming availability of new treatment options and increased healthcare spending across the major markets (7MM) suggest a promising future for endometriosis management. The treatment landscape is expected to experience significant growth during the forecast period (2024-2034).

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Endometriosis Epidemiology

The Endometriosis epidemiology section provides insights into the historical and current Endometriosis patient pool and forecasted trends for seven individual major countries. It helps to recognize the causes of current and forecasted trends by exploring numerous studies and views of key opinion leaders. This part of the Endometriosis market report also provides the diagnosed patient pool, trends, and assumptions.

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Endometriosis Drugs Uptake

This section focuses on the uptake rate of the potential Endometriosis drugs recently launched in the Endometriosis market or expected to be launched in 2019-2032. The analysis covers the Endometriosis market uptake by drugs, patient uptake by therapies, and sales of each drug.

Endometriosis Drugs Uptake helps in understanding the drugs with the most rapid uptake and the reasons behind the maximal use of new drugs and allows the comparison of the drugs based on Endometriosis market share and size, which again will be useful in investigating factors important in market uptake and in making financial and regulatory decisions.

Endometriosis Pipeline Development Activities

The Endometriosis report provides insights into different therapeutic candidates in Phase II, and Phase III stages. It also analyses Endometriosis key players involved in developing targeted therapeutics.

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Endometriosis Therapeutics Assessment

Prominent pharma players such as AbbVie, Neurocrine Biosciences, ObsEva, Kissei Pharmaceuticals, SWK, Enteris BioPharma, Bayer, Hope Medicine, Tiumbio, Organon, and others are working proactively in the Endometriosis Therapeutics market to develop novel therapies which will drive the Endometriosis treatment markets in the upcoming years.

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Endometriosis Report Key Insights

1. Endometriosis Patient Population
2. Endometriosis Market Size and Trends
3. Key Cross Competition in the Endometriosis Market
4. Endometriosis Market Dynamics (Key Drivers and Barriers)
5. Endometriosis Market Opportunities
6. Endometriosis Therapeutic Approaches
7. Endometriosis Pipeline Analysis
8. Endometriosis Current Treatment Practices/Algorithm
9. Impact of Emerging Therapies on the Endometriosis Market

Table of Contents

1. Key Insights
2. Executive Summary
3. Endometriosis Competitive Intelligence Analysis
4. Endometriosis Market Overview at a Glance
5. Endometriosis Disease Background and Overview
6. Endometriosis Patient Journey
7. Endometriosis Epidemiology and Patient Population
8. Endometriosis Treatment Algorithm, Current Treatment, and Medical Practices
9. Endometriosis Unmet Needs
10. Key Endpoints of Endometriosis Treatment
11. Endometriosis Marketed Products
12. Endometriosis Emerging Therapies
13. Endometriosis Seven Major Market Analysis
14. Attribute Analysis
15. Endometriosis Market Outlook (7 major markets)
16. Endometriosis Access and Reimbursement Overview
17. KOL Views on the Endometriosis Market
18. Endometriosis Market Drivers
19. Endometriosis Market Barriers
20. Appendix
21. DelveInsight Capabilities
22. Disclaimer

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