Late-stage Chronic Kidney Disease Market Outlook Report 2032 | ProKidney, Reata Pharmaceuticals, Inc., Novo Nordisk A/S, Boehringer Ingelheim, Eli Lilly and Company, KBP Biosciences, Kibow Pharma, Cincor Pharma, AstraZeneca, Allena Pharmaceuticals, DiaMed

DelveInsight's "Late-stage Chronic Kidney Disease Market Insights, Epidemiology, and Market Forecast-2032" report delivers an in-depth understanding of Late-stage Chronic Kidney Disease, historical and forecasted epidemiology as well as the Late-stage Chronic Kidney Disease market trends in the United States, EU5 (Germany, Spain, Italy, France, and United Kingdom), and Japan.


The Late-stage Chronic Kidney Disease market report provides current treatment practices, emerging drugs, the market share of the individual therapies, and the current and forecasted Late-stage Chronic Kidney Disease market size from 2019 to 2032, segmented by seven major markets. The Report also covers current Late-stage Chronic Kidney Disease treatment practice/algorithm, market drivers, market barriers, and unmet medical needs to curate the best opportunities and assesses the underlying potential of the Late-stage Chronic Kidney Disease market.

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Late-stage Chronic Kidney Disease Overview

Late-stage Chronic Kidney Disease, also known as stage 4 and stage 5 CKD, occurs when kidney function has significantly declined, and the kidneys are no longer able to effectively filter waste products from the blood. Stage 5 CKD is also known as end-stage renal disease (ESRD) or kidney failure.
Late-stage Chronic Kidney Disease Causes
Several factors can lead to the development and progression of CKD:
Diabetes Mellitus:
High blood sugar levels can damage the blood vessels in the kidneys.
Hypertension (High Blood Pressure):
Increased pressure on the kidney's filtering units (glomeruli) can cause damage.
Glomerulonephritis:
Inflammation of the kidney's filtering units.
Polycystic Kidney Disease:
A genetic disorder characterized by the growth of numerous cysts in the kidneys.
Chronic Obstruction:
Prolonged blockage of the urinary tract can lead to kidney damage.
Repeated Kidney Infections (Pyelonephritis):
Recurrent infections can cause scarring and damage to the kidneys.
Autoimmune Diseases:
Conditions such as lupus that cause the immune system to attack the kidneys.
Other Factors:
Long-term use of certain medications (e.g., NSAIDs), heavy metal poisoning, and severe dehydration.
Late-stage Chronic Kidney Disease Signs and Symptoms
As CKD progresses to late stages, symptoms become more pronounced due to the accumulation of waste products and fluid imbalance:
Fatigue and Weakness: Due to anemia and accumulation of waste products.
Edema: Swelling in the legs, ankles, feet, or hands due to fluid retention.
Shortness of Breath: Fluid buildup in the lungs (pulmonary edema) or anemia.
Nausea and Vomiting: Due to the buildup of toxins.
Loss of Appetite: Decreased desire to eat.
Changes in Urination: Decreased urine output, dark-colored urine, or foam in the urine.
Muscle Cramps and Twitches: Due to electrolyte imbalances.
Persistent Itching: Accumulation of waste products in the blood.
Sleep Problems: Insomnia or restless legs syndrome.
Chest Pain: If fluid builds up around the lining of the heart (pericarditis).
Hypertension: Worsening blood pressure control.
Late-stage Chronic Kidney Disease Diagnosis
Diagnosis of late-stage CKD involves a combination of medical history, physical examination, and various diagnostic tests:
Medical History and Physical Examination:
Detailed history of symptoms, underlying conditions, and medication use.
Physical examination to check for signs of edema, hypertension, and other related symptoms.
Laboratory Tests:
Blood Tests: To measure kidney function (e.g., serum creatinine, blood urea nitrogen [BUN]).
Glomerular Filtration Rate (GFR): To assess the level of kidney function. Stage 4 CKD is defined by a GFR of 15-29 mL/min, and stage 5 CKD (ESRD) is defined by a GFR of less than 15 mL/min.
Electrolytes and Acid-Base Balance: To check levels of potassium, sodium, bicarbonate, etc.
Hemoglobin and Hematocrit: To assess for anemia.
Urine Tests:
Urinalysis: To check for abnormalities such as protein, blood, or glucose in the urine.
Urine Albumin-to-Creatinine Ratio: To assess for proteinuria (protein in the urine).
Imaging Studies:
Ultrasound: To visualize the kidneys and detect structural abnormalities.
CT Scan or MRI: In certain cases, to provide more detailed images of the kidneys.
Kidney Biopsy:
In selected cases, to diagnose the specific type of kidney disease and guide treatment.
Late-stage Chronic Kidney Disease Treatment Options
Treatment for late-stage CKD focuses on slowing the progression of the disease, managing symptoms and complications, and preparing for renal replacement therapy (RRT):
Medications:
Antihypertensives: To control blood pressure (e.g., ACE inhibitors, ARBs).
Diuretics: To reduce fluid retention.
Erythropoiesis-Stimulating Agents (ESAs): To treat anemia.
Phosphate Binders: To manage hyperphosphatemia.
Vitamin D Supplements: To correct vitamin D deficiency and manage secondary hyperparathyroidism.
Sodium Bicarbonate: To treat metabolic acidosis.
Dietary Modifications:
Low-Sodium Diet: To control blood pressure and reduce fluid retention.
Low-Protein Diet: To reduce the workload on the kidneys, with appropriate adjustments in ESRD.
Potassium and Phosphorus Restrictions: To manage electrolyte imbalances.
Fluid Restrictions: As necessary to prevent fluid overload.
Dialysis:
Hemodialysis: Blood is filtered through a machine outside the body.
Peritoneal Dialysis: The lining of the abdomen (peritoneum) acts as a filter to clear waste from the blood.
Dialysis is usually initiated when GFR falls below 15 mL/min or when symptoms become severe.
Kidney Transplant:
A kidney transplant involves surgically placing a healthy kidney from a donor into a person with ESRD.
Considered the best long-term solution for suitable candidates.
Supportive Care and Symptom Management:
Pain Management: For those with significant discomfort.
Nutritional Support: To ensure adequate calorie and nutrient intake.
Psychological Support: Counseling and support groups to help cope with the emotional aspects of CKD.
Late-stage Chronic Kidney Disease Follow-up and Monitoring
Regular follow-up is crucial for managing late-stage CKD:
Frequent Monitoring: Regular blood and urine tests to monitor kidney function and electrolyte levels.
Adjusting Treatment: Based on test results and changes in symptoms.
Managing Complications: Early identification and management of complications such as cardiovascular disease, bone disease, and infections.
Effective management of late-stage CKD involves a multidisciplinary approach, including nephrologists, dietitians, social workers, and other healthcare professionals to provide comprehensive care and support.

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Late-stage Chronic Kidney Disease Market

The Late-stage Chronic Kidney Disease market outlook of the report helps to build a detailed comprehension of the historical, current, and forecasted Late-stage Chronic Kidney Disease market trends by analyzing the impact of current Late-stage Chronic Kidney Disease therapies on the market and unmet needs, drivers, barriers, and demand for better technology.

This segment gives a thorough detail of the Late-stage Chronic Kidney Disease market trend of each marketed drug and late-stage pipeline therapy by evaluating their impact based on the annual cost of therapy, inclusion and exclusion criteria, mechanism of action, compliance rate, growing need of the market, increasing patient pool, covered patient segment, expected launch year, competition with other therapies, brand value, their impact on the market and view of the key opinion leaders. The calculated Late-stage Chronic Kidney Disease market data are presented with relevant tables and graphs to give a clear view of the market at first sight.

According to DelveInsight, the Late-stage Chronic Kidney Disease market in 7MM is expected to witness a major change in the study period 2019-2032.

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Late-stage Chronic Kidney Disease Epidemiology

The Late-stage Chronic Kidney Disease epidemiology section provides insights into the historical and current Late-stage Chronic Kidney Disease patient pool and forecasted trends for seven individual major countries. It helps to recognize the causes of current and forecasted trends by exploring numerous studies and views of key opinion leaders. This part of the Late-stage Chronic Kidney Disease market report also provides the diagnosed patient pool, trends, and assumptions.

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Late-stage Chronic Kidney Disease Drugs Uptake

This section focuses on the uptake rate of the potential Late-stage Chronic Kidney Disease drugs recently launched in the Late-stage Chronic Kidney Disease market or expected to be launched in 2019-2032. The analysis covers the Late-stage Chronic Kidney Disease market uptake by drugs, patient uptake by therapies, and sales of each drug.

Late-stage Chronic Kidney Disease Drugs Uptake helps in understanding the drugs with the most rapid uptake and the reasons behind the maximal use of new drugs and allows the comparison of the drugs based on Late-stage Chronic Kidney Disease market share and size, which again will be useful in investigating factors important in market uptake and in making financial and regulatory decisions.

Late-stage Chronic Kidney Disease Pipeline Development Activities

The Late-stage Chronic Kidney Disease report provides insights into different therapeutic candidates in Phase II and Phase III stages. It also analyses Late-stage Chronic Kidney Disease key players involved in developing targeted therapeutics.

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Late-stage Chronic Kidney Disease Therapeutics Assessment

Prominent players such as ProKidney, Reata Pharmaceuticals, Inc., Novo Nordisk A/S, Boehringer Ingelheim, Eli Lilly and Company, KBP Biosciences, Kibow Pharma, Cincor Pharma, AstraZeneca, Allena Pharmaceuticals, DiaMedica Therapeutics Inc, Lexicon Pharmaceuticals, Sanofi, and others are working proactively in the Late-stage Chronic Kidney Disease Therapeutics market to develop novel therapies which will drive the Late-stage Chronic Kidney Disease treatment markets in the upcoming years.

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Late-stage Chronic Kidney Disease Report Key Insights

1. Late-stage Chronic Kidney Disease Patient Population
2. Late-stage Chronic Kidney Disease Market Size and Trends
3. Key Cross Competition in the Late-stage Chronic Kidney Disease Market
4. Late-stage Chronic Kidney Disease Market Dynamics (Key Drivers and Barriers)
5. Late-stage Chronic Kidney Disease Market Opportunities
6. Late-stage Chronic Kidney Disease Therapeutic Approaches
7. Late-stage Chronic Kidney Disease Pipeline Analysis
8. Late-stage Chronic Kidney Disease Current Treatment Practices/Algorithm
9. Impact of Emerging Therapies on the Late-stage Chronic Kidney Disease Market

Table of Contents

1. Key Insights
2. Executive Summary
3. Late-stage Chronic Kidney Disease Competitive Intelligence Analysis
4. Late-stage Chronic Kidney Disease Market Overview at a Glance
5. Late-stage Chronic Kidney Disease Disease Background and Overview
6. Late-stage Chronic Kidney Disease Patient Journey
7. Late-stage Chronic Kidney Disease Epidemiology and Patient Population
8. Late-stage Chronic Kidney Disease Treatment Algorithm, Current Treatment, and Medical Practices
9. Late-stage Chronic Kidney Disease Unmet Needs
10. Key Endpoints of Late-stage Chronic Kidney Disease Treatment
11. Late-stage Chronic Kidney Disease Marketed Products
12. Late-stage Chronic Kidney Disease Emerging Therapies
13. Late-stage Chronic Kidney Disease Seven Major Market Analysis
14. Attribute Analysis
15. Late-stage Chronic Kidney Disease Market Outlook (7 major markets)
16. Late-stage Chronic Kidney Disease Access and Reimbursement Overview
17. KOL Views on the Late-stage Chronic Kidney Disease Market
18. Late-stage Chronic Kidney Disease Market Drivers
19. Late-stage Chronic Kidney Disease Market Barriers
20. Appendix
21. DelveInsight Capabilities
22. Disclaimer

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