Oligonucleotide Synthesis, Modification, and Purification Services Market: A $7.83 Billion Opportunity by 2031 (Highlights projected market size)

Oligonucleotide Synthesis, Modification, and Purification Services Market worth $7.83 Billion by 2031 - Exclusive Report by InsightAce Analytic

InsightAce Analytic Pvt. Ltd. announces the release of a market assessment report on the " Global Oligonucleotide Synthesis, Modification and Purification Services Market Oligonucleotide Mfg. Type (Antisense Oligonucleotides, siRNA, miRNA, And Other Oligonucleotides), Applications (Research And Diagnostic, Therapeutic, And Contract Manufacturing (OEM)), Operation Scale (Large-Scale Oligonucleotide Synthesis, Intermediate-Scale Oligonucleotide Synthesis, And Small-Scale Oligonucleotide Synthesis),

Therapeutic Areas (Oncological Disorders, Eye Disorders, Metabolic Disorders, Autoimmune Disorders, And Other Therapeutic Areas), End-users (Pharmaceutical & Biotechnology Companies, Hospitals & Diagnostic Laboratories, Contract Research Organizations (Cros) And Contract Manufacturing Organizations (Cmos), And Academic Research Institutes) - Trends, Industry Competition Analysis, Revenue, and Forecast till 2030."

According to the latest research by InsightAce Analytic, the global oligonucleotide synthesis, modification, and purification services market was valued at 1.77 Billion in 2022 and is predicted to reach 7.83 Billion by the year 2031 at an 18.08 % CAGR during the forecast period for 2023-2031.
Major market players operating in the oligonucleotide synthesis, modification, and purification services market include Ajinomoto Bio-Pharma Services, Integrated DNA Technologies, Kaneka Eurogentec, LGC Biosearch Technologies, Microsynth,

MilliporeSigma, BioSpring, CordenPharma, Nitto Denko Avecia, TriLink Biotechnologies, Eurofins Scientific SE, Thermo Fisher Scientific Inc., Agilent Technologies, Inc., GE Healthcare, GeneDesign, Inc., Bio-synthesis Inc., ATDBio Ltd, Burkert UK Limited, Almac Group, and Other Prominent Players.

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Modified oligoribonucleotides , also known as short, single-stranded DNA or RNA molecules, have recently gained significant attention in molecular biology, biochemistry, and medicine . These synthetic DNA or RNA oligonucleotides, produced through solid-phase synthesis, are instrumental in various molecular biology applications, including real-time PCR, sequencing, site-directed mutagenesis, PCR, microarrays, and single nucleotide polymorphism (SNP) tests. The extensive study on chemically modified oligonucleotides over the years has paved the way for the development of new antisense and siRNA treatments.

This progress holds promise for the prompt production of novel vaccines and pharmaceuticals, driving the need for more robust and dependable instruments for characterizing and tracking oligonucleotide and mRNA products. The demand for oligonucleotides is anticipated to rise during the forecast period due to several factors, including the growing need for specialized, high-quality oligos for NGS applications, advancements in synthesis and purification technologies, an increase in product launches by industry players, a high prevalence of genetic and chronic disorders, an ageing population, an increase in custom oligo synthesis services, an increase in R&D activity in biotechnology companies to improve oligo synthesis and purification processes, and a rise in the demand for personalized medicines.

Furthermore, it is anticipated that the market's growth will be bolstered shortly by the companies' expansion of their manufacturing facilities and their use of partnerships, mergers, and agreements. For example, an oligonucleotide synthesis collaboration agreement was signed in February 2018 between Regulus Therapeutics (US) and STA Pharmaceutical Co. (China), a company within the WuXi AppTec group, for research and mid-scale non-GMP/cGMP manufacture. Furthermore, CordenPharma International and GE Healthcare's Dharmacon business collaborated in June 2017 to create a comprehensive solution for oligonucleotide-based drug development. However,

it's important to note that despite the high costs associated with the purification process, intricate manufacturing techniques, oligo-degradation in generic research, and internal oligonucleotide creation , the worldwide market for oligonucleotide synthesis, modification, and purification services remains resilient. This resilience is a testament to the industry's ability to overcome challenges and maintain its growth trajectory. Geographically,

it is anticipated that North America will hold the largest share of this market throughout the forecast years, followed by Europe. Due to improved healthcare infrastructures and the rising use of oligonucleotides in developing innovative medicinal therapies, Europe is predicted to rise significantly in this market.

Key Developments In The Market:

• In Oct 2021, TriLink BioTechnologies stated that it plans to provide EyeGene, Inc. with its CleanCap® mRNA capping process and the modified nucleoside, uridine triphosphate, for the manufacturing of EyeGene's mRNA COVID-19 vaccine. This cooperation with EyeGene is anticipated to be the first clinical-stage initiative to utilise TriLink's GMP-grade modified uridine triphosphate designed for further processing.

• In June 2021, Thermo Fisher Scientific teamed up to build end-to-end procedures for complicated oligonucleotide and mRNA products. This collaboration combines the University of Sheffield's research expertise with Thermo Fisher's sample preparation, liquid chromatography (LC), high-resolution accurate-mass (HRAM), mass spectrometry (MS), and data interpretation software technologies to develop streamlined analytical workflows and robust fit-for-purpose processes.

• In January 2021, MilliporeSigma (US) acquired AmpTec, a leading Germany-based mRNA contract development and manufacturing organization (CDMO). The deal strengthens MilliporeSigma's capabilities to develop and manufacture mRNA for its customers for use in vaccines, treatments, and diagnostics applicable in Covid-19 and many other diseases.

• In September 2019, GeneDesign (Japan) acquired Ajinomoto Bio-Pharma Services, becoming part of the contract development and manufacturing organization (CDMO). The integration of GeneDesign's services offerings with Aji Bio-Pharma's small and large molecule capabilities in the U.S., Belgium, and India strengthens the CDMO's capabilities.

• In 2019, Integrated DNA Technology (US) launched 'oPools- oligo pools', a pool of high-quality DNA oligonucleotides with 350 nucleotides in length.

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Market Segments
Global Oligonucleotide Synthesis, Modification, and Purification Services Market, by By Oligonucleotide mfg. Types, 2022-2030 (Value US$ Bn)

• Antisense Oligonucleotides
• siRNA
• shRNA
• miRNA
• Aptamers
• Primers
• Probes
• Others (Adapters for NSG)

Global Oligonucleotide Synthesis, Modification, and Purification Services Market, by Applications, 2022-2030 (Value US$ Bn)

• Research and Diagnostic
o PCR
o qPCR/RTqPCR
o Sequencing
o Gene Synthesis
o Other Research Applications
• Therapeutic
o RNAi Oligonucleotide-based Therapies
o DNA/Antisense oligonucleotide-based Therapies
o Immunotherapy (CpG Oligonucleotide-based Therapies)
o Nucleic Acid Aptamer
• Contract Manufacturing

Global Oligonucleotide Synthesis, Modification, and Purification Services Market, by Operation Scale, 2022-2030 (Value US$ Bn)

• Large-Scale Oligonucleotide Synthesis
• Intermediate-Scale Oligonucleotide Synthesis
• Small-Scale Oligonucleotide Synthesis

Global Oligonucleotide Synthesis, Modification, and Purification Services Market, by Therapeutic Areas, 2022-2030 (Value US$ Bn)

• Oncological Disorders
• Eye Disorders
• Metabolic Disorders
• Autoimmune Disorders
• Other Therapeutic Areas

Global Oligonucleotide Synthesis, Modification, and Purification Services Market, by End-Users, 2022-2030 (Value US$ Bn)

• Pharmaceutical & Biotechnology Companies
• Hospitals & Diagnostic Laboratories
• Contract research organisations (CROs) and contract manufacturing organisations (CMOs)

• Academic Research Institutes

Global Oligonucleotide Synthesis, Modification, and Purification Services Market, by Region, 2022-2030 (Value US$ Bn)

• North America
• Europe
• Asia Pacific
• Latin America
• Middle East & Africa

North America Oligonucleotide Synthesis, Modification, and Purification Services Market, by Country, 2022-2030 (Value US$ Bn)

• U.S.
• Canada

Europe Oligonucleotide Synthesis, Modification, and Purification Services Market, by Country, 2022-2030 (Value US$ Bn)

• Germany
• France
• Italy
• Spain
• Russia
• Rest of Europe

Asia Pacific Oligonucleotide Synthesis, Modification, and Purification Services Market, by Country, 2022-2030 (Value US$ Bn)

• India
• China
• Japan
• South Korea
• Australia & New Zealand

Latin America Oligonucleotide Synthesis, Modification, and Purification Services Market, by Country, 2022-2030 (Value US$ Bn)

• Brazil
• Mexico
• Rest of Latin America

Middle East & Africa Oligonucleotide Synthesis, Modification, and Purification Services Market, by Country, 2022-2030 (Value US$ Bn)

• GCC Countries
• South Africa
• Rest of Middle East & Africa

Why should buy this report:

 To receive a comprehensive analysis of the prospects for the global oligonucleotide synthesis, modification, and purification services market
 To receive an industry overview and future trends of the oligonucleotide synthesis, modification, and purification services market
 To analyze the oligonucleotide synthesis, modification, and purification services market drivers and challenges
 To get information on the oligonucleotide synthesis, modification, and purification services market size value (US$ Mn) forecast to 2030
 Major Investments, Mergers & Acquisition in the oligonucleotide synthesis, modification, and purification services market industry

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Other Related Reports Published by InsightAce Analytic:

Global mRNA Extraction and Purification Market

Global Antibody Purification Services Market

Global Antisense Oligonucleotide Therapeutics Market

Global mRNA Synthesis and Manufacturing Services Market

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