"Cell-Free Protein Synthesis Market Booming Growth-focused Set to Reach $457.1 Million by 2031"

Cell Free Protein Synthesis Market Worth USD 457.1 Million by 2031

Global Cell Free Protein Synthesis Market is valued at US$ 265.9 Mn in 2023, and it is expected to reach US$ 457.1 Mn by 2031, with a CAGR of 7.2% during the forecast period of 2024-2031.

CFPS (Cell-free protein synthesis) is an innovative technology that enables fast and simultaneous protein expression, free from cell membrane limitations. Its adaptability and efficiency make it a promising avenue for future drug development. By tapping into cellular translation machinery, CFPS simplifies protein synthesis while maintaining high quality. Its benefits include time-saving processes, flexibility, and the ability to handle even challenging proteins.

In biotechnology, CFPS finds diverse applications, spanning from producing therapeutic and membrane proteins to aiding drug discovery. It simplifies structural and functional protein analysis, eliminating the need for complex cell manipulation steps. CFPS comes in various formats, such as the PURE system and different batch and continuous flow methods, offering options tailored to specific needs. This versatility promises a straightforward path towards more efficient and cost-effective protein production for pharmaceuticals and other biotech products.

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Recent Developments:

• In March 2024, Tierra Biosciences, a leader in using smart technology for making proteins, just got $11.4 million in funding. Big investors like Material Impact and Prosus Ventures are supporting them. This money will help Tierra make their protein-making technology even better, bringing new advances to biotech and protein science.

• In May 2024, Thermo Fisher Scientific finalized its acquisition of data intelligence firm CorEvitas for $912.5 million in cash. This acquisition, first announced on July 6th, will see CorEvitas become part of Thermo Fisher's Laboratory Products and Biopharma Services segment. CorEvitas, based in the US, offers real-world evidence solutions to pharmaceutical and biotech companies, collecting data from over 400 investigator sites and 100,000 patients. With 12 registries under its management, including nine autoimmune and inflammatory syndicated registries, CorEvitas is projected to generate $110 million in revenue by 2023.

List of Prominent Players in the Cell Free Protein Synthesis Market:
• BioCentury Inc.
• Biotechrabbit GmbH
• Cube Biotech GmbH
• GeneCopoeia, Inc.
• Sutro Biopharma, Inc.
• Promega Corporation
• Thermo Fisher Scientific
• Takara Bio Inc.
• CellFree Sciences Co., Ltd.
• Merck KGaA
• New England Biolabs
• Jena Biosciences GmbH
• Other Prominent Players

Market Dynamics:
Drivers:
Because chronic diseases like HIV, multiple sclerosis, cancer, and anaemia are becoming more and more common, there is a growing need for therapeutic proteins. The acceptance of protein biology has increased due to this boom, providing targeted therapies with fewer adverse effects. Concurrently, production techniques have revolutionized thanks to developments in protein expression studies, especially with Continuous-Exchange Cell-free (CECF) systems.

Comparing CECF to conventional batch reactions, the former increases protein yield while the latter prolongs the reaction lifetime. This invention satisfies the requirement for specific protein sequences and architectures by enabling structural alterations and facilitating faster expression rates.
Furthermore, cloning and cell culture are avoided using cell-free protein synthesis (CFPS), which increases output overall and improves adaptability for high-throughput applications.

The market for cell-free protein synthesis is further driven by rising R&D spending in proteomics and genomics and the rising incidence of infectious diseases and cancer. Pharmaceutical and biotech businesses increasingly use these technologies to spur innovation and satisfy the increasing demand for innovative biological goods.

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Challenges:
The widespread adoption of cell-free protein synthesis (CFPS) is hindered by several challenges. Foremost among these is the inability of CFPS to facilitate post-translational modifications, limiting its utility in synthesizing specific human therapeutics. Nonetheless, considerable strides have been made to overcome this limitation.

Another significant barrier is the high cost associated with CFPS technology, which restricts its accessibility to many companies and research institutions. Addressing this issue necessitates the reduction of reagent costs, particularly those related to energy sources and nucleotides. Additionally, protein folding complexities pose a formidable challenge for current CFPS systems, impeding the production of properly folded, functional proteins. Overcoming these challenges is crucial for unlocking the full potential of CFPS in biopharmaceutical production.

Regional Trends:
The cell-free protein synthesis market exhibits distinct regional trends, with North America emerging as the dominant player and the Asia Pacific region showing promising growth prospects. In North America, the market's supremacy is fueled by the presence of robust synthetic biology R&D facilities, advanced tools supporting synthesis processes, and a growing prevalence of chronic diseases like cancer, which boosts the frequency of cell-free protein synthesis applications.

Key drivers include escalating demand for therapeutic proteins, enzymes, and research reagents, alongside advancements in proteomics and genomics studies. Conversely, the Asia Pacific region is poised for significant expansion, driven by increasing research investments in countries such as Japan and China, the evolution of new drug therapeutic technologies, and a burgeoning focus on cell-based research in academia and the biotech sector.

Segmentation of Cell Free Protein Synthesis Market-
Cell Free Protein Synthesis Market- By Product
• Accessories and Consumables
• Lysate Systems
o Coli Lysate
o Wheat Germ Extract Lysate
o Insect Cell Lysate
o Human Cell Lysate
o Rabbit Reticulocyte Lysate
o Other Lysate Systems

Cell Free Protein Synthesis Market- By Application
o Enzyme Engineering
o Protein Labeling
o Protein-Protein Interaction
o High Throughput Production
o Other Application

Cell Free Protein Synthesis Market- By End-user
o Pharmaceutical & Biotechnology Companies
o Academics & Research Institutes
o Others

Cell Free Protein Synthesis Market- By Region
North America-
• The US
• Canada
• Mexico

Europe-
• Germany
• The UK
• France
• Italy
• Spain
• Rest of Europe

Asia-Pacific-
• China
• Japan
• India
• South Korea
• Southeast Asia
• Rest of Asia Pacific

Latin America-
• Brazil
• Argentina
• Rest of Latin America

Middle East & Africa-
• GCC Countries
• South Africa
• Rest of the Middle East and Africa

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This release was published on openPR.