Chronic Lymphocytic Leukemia Pipeline Outlook Report 2024 (Updated)

DelveInsight's, "Chronic Lymphocytic Leukemia Pipeline Insight 2024" report provides comprehensive insights about 55+ companies and 60+ pipeline drugs in Chronic Lymphocytic Leukemia pipeline landscape. It covers the Chronic Lymphocytic Leukemia pipeline drug profiles, including clinical and nonclinical stage products. It also covers the Chronic Lymphocytic Leukemia pipeline therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

Key Takeaways from the Chronic Lymphocytic Leukemia Pipeline Report
• DelveInsight's Chronic Lymphocytic Leukemia pipeline report depicts a robust space with 55+ active players working to develop 60+ pipeline therapies for Chronic Lymphocytic Leukemia treatment.
• The leading companies working in the Chronic Lymphocytic Leukemia Market include Loxo Oncology, Oncternal Therapeutics, MingSight Pharmaceuticals, Nurix Therapeutics, Starton Therapeutics, TG therapeutics, Bristol Myers Squibb, Novartis, Aprea Therapeutics, AstraZeneca, Genor Biopharma, Incyte Corporation, MorphoSys, Astex Therapeutics, Lava Therapeutics, Celgene Corporation, and others.
• Promising Chronic Lymphocytic Leukemia Pipeline Therapies in the various stages of development include Acalabrutinib, ABT-263, Bendamustine, Venetoclax, Rituximab, FCR, and others.
• April 2024: Loxo Oncology Inc. announced a study of Phase 3 clinical trials for Pirtobrutinib, Bendamustine and Rituximab. The purpose of this study is to compare the efficacy and safety of pirtobrutinib (LOXO-305; Arm A) compared to BR (Arm B) in patients with CLL/SLL who have not been treated. Participation could last up to five years.
• April 2024: Pharmacyclics LLC announced a study of Phase 2 clinical trials for ibrutinib and venetoclax. This is a multicenter, 2-cohort Phase 2 study assessing both minimal residual disease (MRD)-guided discontinuation and fixed duration therapy with the combination of ibrutinib + venetoclax in subjects with treatment-naïve CLL or SLL.
• April 2024: Genmab announced a study of Phase 1 & 2 clinical trials for Venetoclax and Lenalidomide. The purpose of the dose-escalation phase of the trial is to determine the recommended phase 2 dose (RP2D) and the maximum tolerated dose (MTD; if reached) as well as establish the safety profile of epcoritamab monotherapy and epcoritamab + venetoclax in participants with R/R CLL.

Request a sample and discover the recent advances in Chronic Lymphocytic Leukemia Treatment Drugs @ Chronic Lymphocytic Leukemia Infection Pipeline Outlook Report- https://www.delveinsight.com/sample-request/chronic-lymphocytic-leukemia-cll-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=ypr

The Chronic Lymphocytic Leukemia pipeline report provides detailed profiles of pipeline assets, a comparative analysis of clinical and non-clinical stage Chronic Lymphocytic Leukemia drugs, inactive and dormant assets, a comprehensive assessment of driving and restraining factors, and an assessment of opportunities and risks in the Chronic Lymphocytic Leukemia clinical trial landscape.

Chronic Lymphocytic Leukemia Overview
Chronic lymphocytic leukemia (CLL) is a malignancy of CD5+ B cells that is characterized by the accumulation of small, mature-appearing neoplastic lymphocytes in the blood, bone marrow, and secondary lymphoid tissues, resulting in lymphocytosis, leukemia cell infiltration of the bone marrow, lymphadenopathy, and splenomegaly. The exact etiology of CLL is unknown.

Find out more about Chronic Lymphocytic Leukemia Treatment Landscape @ Drugs for Chronic Lymphocytic Leukemia Treatment- https://www.delveinsight.com/sample-request/chronic-lymphocytic-leukemia-cll-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=ypr

Chronic Lymphocytic Leukemia Emerging Drugs Profile

Pirtobrutinib: Loxo Oncology
Pirtobrutinib is an investigational, oral, highly-selective, non-covalent Bruton's tyrosine kinase (BTK) inhibitor. BTK plays a key role in the B-cell antigen receptor, signaling pathway, which is required for the development, activation and survival of normal white blood cells, known as B-cells, and malignant B-cells. Pirtobrutinib was designed to reversibly bind BTK, deliver consistently high target coverage regardless of BTK turnover rate, preserve activity in the presence of the C481 acquired resistance mutations, and avoid off-target kinases that have complicated the development of both covalent and investigational non-covalent BTK inhibitors. The drug is currently being evaluated in Phase III stage of development for the treatment of chronic lymphocytic leukemia.

Cirmtuzumab: Oncternal Therapeutics
Cirmtuzumab is a first-in-class humanized monoclonal antibody that binds with high affinity to a biologically important epitope on ROR1 (Receptor-tyrosine kinase-like Orphan Receptor 1). ROR1 is a type 1 transmembrane protein, essential for fetal development that is expressed on the plasma membrane with an extracellular domain that is essential for ligand binding and signal transduction. Cirmtuzumab binds to many different types of cancer cells but does not recognize most normal adult tissues. Cirmtuzumab was developed at the University of California in San Diego based on the pioneering scientific research of Thomas Kipps, MD, Ph.D., and his colleagues at the Moores Cancer Center. Oncternal holds an exclusive worldwide license to develop and commercialize antibodies recognizing ROR1. The development of cirmtuzumab has been supported by the California Institute for Regenerative Medicine (CIRM), in recognition of the role of ROR1 in conferring stem cell-like properties to the cancer cells that express it. A Phase II clinical trial is evaluating Cirmtuzumab to treat CLL.

MS-553: MingSight Pharmaceuticals
MS-553 is a potent, highly selective, oral, non-covalent inhibitor of PKCβ, a signaling molecule immediately downstream of BTK and PLCγ2 in the B-cell receptor (BCR) pathway. As PKCβ is downstream of both BTK and PLCγ2, it has the potential to treat acquired BTK resistance mutations in either protein, a feature absent from many second-generation BTK inhibitors. In the preliminary results, MS-553 was generally well tolerated, with initial anti-tumor activity seen in the heavily pretreated population. Potent to full inhibition of PKCβ signaling over 24 hours of exposure has been demonstrated. Additional dosing of patients will be completed to further assess MS-553 efficacy in patients with acquired resistance mutations in BTK and PLCG2. Currently, the drug is being evaluated in the Phase I/II stage of its development for the treatment of CLL.

NX-2127: Nurix Therapeutics
NX-2127 is an oral small molecule that combines the activity of a targeted BTK degrader with the cereblon immunomodulatory activity of an IKZF degrader. Cereblon immunomodulatory drugs that induce degradation are IKZF1 and IKZF3. Preclinical data support the activity of NX-2127 in tumor models harboring either wild-type BTK or BTK with mutations conferring clinical resistance to FDA-approved agents. Studies in non-human primates confirm potent BTK degradation with once-daily oral dosing. NX-2127 is being tested in an ongoing Phase I trial for patients with chronic lymphocytic leukemia who have failed prior treatments.

NX-5948: Nurix Therapeutics
NX-5948 is an oral small molecule degrader of BTK. Preclinical data support the activity of NX-5948 in tumor models harboring either wild-type BTK or BTK with mutations conferring clinical resistance to leading FDA approved agents. NX-5948 lacks cereblon immunomodulatory activity and has demonstrated the ability to cross the blood-brain barrier in animal models. NX-5948 has also demonstrated activity in animal models of autoimmune disease. The drug is currently being evaluated in the Phase I stage of development for the treatment of chronic lymphocytic leukemia.

Chronic Lymphocytic Leukemia Pipeline Therapeutics Assessment
There are approx. 55+ key Chronic Lymphocytic Leukemia companies which are developing the Chronic Lymphocytic Leukemia therapies. The Chronic Lymphocytic Leukemia companies which have their chronic lymphocytic leukemia drug candidates in the most advanced stage, i.e. phase III include, Loxo Oncology.

DelveInsight's Chronic Lymphocytic Leukemia pipeline report covers around 60+ products under different phases of clinical development like
• Late stage products (Phase III)
• Mid-stage products (Phase II)
• Early-stage product (Phase I) along with the details of
• Pre-clinical and Discovery stage candidates
• Discontinued & Inactive candidates

Chronic lymphocytic leukemia pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as
• Intravenous
• Subcutaneous
• Oral
• Intramuscular

Products have been categorized under various Molecule types such as
• Monoclonal antibody
• Small molecule
• Peptide

Learn more about the emerging Chronic Lymphocytic Leukemia Pipeline Therapies @ Chronic Lymphocytic Leukemia Clinical Trials Assessment- https://www.delveinsight.com/sample-request/chronic-lymphocytic-leukemia-cll-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=ypr

Scope of the Chronic Lymphocytic Leukemia Pipeline Report
• Coverage- Global
• Therapeutic Assessment by Product Type: Mono, Combination, Mono/Combination
• Therapeutic Assessment by Clinical Stages: Discovery, Pre-clinical, Phase I, Phase II, Phase III
• Chronic Lymphocytic Leukemia Companies- Loxo Oncology, Oncternal Therapeutics, MingSight Pharmaceuticals, Nurix Therapeutics, Starton Therapeutics, TG therapeutics, Bristol Myers Squibb, Novartis, Aprea Therapeutics, AstraZeneca, Genor Biopharma, Incyte Corporation, MorphoSys, Astex Therapeutics, Lava Therapeutics, Celgene Corporation, and others.
• Chronic Lymphocytic Leukemia Pipeline Therapies- Acalabrutinib, ABT-263, Bendamustine, Venetoclax, Rituximab, FCR, and others.

Dive deep into rich insights for new drugs for Chronic Lymphocytic Leukemia treatment, Visit @ Chronic Lymphocytic Leukemia Market Drivers and Barriers, and Future Perspective- https://www.delveinsight.com/sample-request/chronic-lymphocytic-leukemia-cll-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=ypr

Table of Content
1. Introduction
2. Executive Summary
3. Chronic lymphocytic leukemia: Overview
4. Pipeline Therapeutics
5. Therapeutic Assessment
6. Chronic lymphocytic leukemia- DelveInsight's Analytical Perspective
7. Late Stage Products (Phase III)
8. Pirtobrutinib: Loxo Oncology
9. Drug profiles in the detailed report…..
10. Mid Stage Products (Phase II)
11. Cirmtuzumab: Oncternal Therapeutics
12. Drug profiles in the detailed report…..
13. Early Stage Products (Phase I)
14. NX-2127: Nurix Therapeutics
15. Drug profiles in the detailed report…..
16. Preclinical and Discovery Stage Products
17. Drug name: Company name
18. Drug profiles in the detailed report…..
19. Inactive Products
20. Chronic lymphocytic leukemia Key Companies
21. Chronic lymphocytic leukemia Key Products
22. Chronic lymphocytic leukemia- Unmet Needs
23. Chronic lymphocytic leukemia- Market Drivers and Barriers
24. Chronic lymphocytic leukemia- Future Perspectives and Conclusion
25. Chronic lymphocytic leukemia Analyst Views
26. Chronic lymphocytic leukemia Key Companies
27. Appendix

For further information on the Chronic Lymphocytic Leukemia pipeline therapeutics, reach out to Chronic Lymphocytic Leukemia Unmet Needs and Analyst Views- https://www.delveinsight.com/sample-request/chronic-lymphocytic-leukemia-cll-pipeline-insight?utm_source=openpr&utm_medium=pressrelease&utm_campaign=ypr

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About Us

DelveInsight is a leading healthcare-focused market research and consulting firm that provides clients with high-quality market intelligence and analysis to support informed business decisions. With a team of experienced industry experts and a deep understanding of the life sciences and healthcare sectors, we offer customized research solutions and insights to clients across the globe. Connect with us to get high-quality, accurate, and real-time intelligence to stay ahead of the growth curve.

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This release was published on openPR.