Metastatic Urothelial Carcinoma Market to Expand at a Significant Growth Rate During the Forecast Period (2023-32) - Estimates DelveInsight | PharmaMar, Ectin Research, Exelixis, Eli Lilly, Merck, Astellas Seagen, and Advaxis

The Metastatic Urothelial Carcinoma market is undergoing rapid evolution, spurred by advancements in immunotherapy and targeted therapies. Clinical trials exploring novel treatment combinations and biomarkers are reshaping the landscape of care, offering new hope for patients with advanced diseases. Moreover, collaborations between pharmaceutical companies and research institutions are driving innovation, leading to more personalized and effective treatment strategies for Metastatic Urothelial Carcinoma.

DelveInsight's "Metastatic Urothelial Carcinoma Market Insights, Epidemiology, and Market Forecast 2032" report delivers an in-depth understanding of the disease, historical and forecasted epidemiology, as well as the Metastatic Urothelial Carcinoma Market Size and Share in the seven major markets (7MM) (i.e., the United States, EU4 (Germany, Spain, Italy, France), the United Kingdom and Japan).

The market report covers emerging drugs, treatment practices, market share of individual Metastatic Urothelial Carcinoma therapies, and current & forecasted market size from 2019 to 2032. It also evaluates the current Metastatic Urothelial Carcinoma treatment practice/algorithm, market drivers & barriers, and unmet medical needs to curate the best of opportunities and assess the underlying potential of the market.

Metastatic Urothelial Carcinoma: An Overview
Urothelial Carcinoma starts when cells that make up the urinary bladder become cancerous. Bladder neoplasms can arise from any of the four bladder wall layers. They are broadly classified as either epithelial or non-epithelial (mesenchymal), with over 95% being epithelial. Epithelial tumors with differentiation toward normal urothelium are urothelial/ urinary carcinoma. Other types of bladder neoplasms, namely, squamous cell carcinoma, adenocarcinoma, small cell carcinoma, and sarcoma account for 2-5% of bladder neoplasms.

The majority of Urothelial Carcinoma occurs in males with approximately two to threefold greater incidence as compared to females. Urothelial Carcinoma is the invasion of the basement membrane or lamina propria by neoplastic cells of urothelial origin.

The main causative agents of upper tract Urothelial Carcinoma and urinary bladder cancer include cigarette smoking and work-related exposure, while other factors are more specific to the carcinogenesis of upper tract Urothelial Carcinoma (i.e., Balkan endemic nephropathy).

From a clinical point of view, urinary bladder cancers are classified as non-muscle-invasive bladder cancer (NMIBC) and muscle-invasive bladder cancer (MIBC), because the invasion of the muscle layer is the major determinant of carrying out a cystectomy. The 5-year relative survival rate for patients with UBC ranges from 97% (stage I) to 22% (stage IV).

The World Health Organization classifies bladder cancers based on type of tumor, from low-grade (grade I and II) to high-grade (grade III). The WHO has substituted the old term provisional cell carcinoma with urothelial carcinoma. Invasion is referred to as 'microinvasion' when the complexity of invasion is 2 mm or less.

Metastatic Urothelial Carcinoma Market Key Facts
• As per the National Cancer Institute, a high increase in the number of cases of Urothelial Carcinoma with an estimated number of 80,470 newly diagnosed cases and 17,670 deaths were expected in 2019 in the United States.
• A review paper published by Clinton et al. titled "Review of the Clinical Approaches to the Use of Urine-based Tumor Markers in Bladder Cancer", stated that approximately 75% of newly diagnosed bladder cancer cases present as non-muscle invasive bladder cancer (NMIBC) out of which 50-70% recur and 10-20% progress to muscle-invasive bladder cancer (MIBC).
• The total incident population of Urothelial Carcinoma in the seven major markets was found to be 243,151 cases in 2017, whereas the total cases of locally advanced/metastatic Urothelial Carcinoma in the 7MM were 96,711 cases in 2017. The diagnosed incident population of Urothelial Carcinoma in the 7MM is expected to increase at a CAGR for the study period, i.e., 2017-2030.
• Among EU5 countries, Germany had the maximum total cases of locally advanced/metastatic Urothelial Carcinoma with 15,192 cases in 2017.

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Metastatic Urothelial Carcinoma Market
The market outlook section of the report helps to build a detailed comprehension of the historical, current, and forecasted market size by analyzing the impact of current and emerging Metastatic Urothelial Carcinoma therapies in the market. It also provides a detailed assessment of the Metastatic Urothelial Carcinoma market drivers & barriers, unmet needs, and emerging technologies.

The report gives complete details of the market trend for each marketed Metastatic Urothelial Carcinoma drug and late-stage pipeline therapies by evaluating their impact based on the annual cost of therapy, inclusion and exclusion criteria, mechanism of action (MOA), competition with other therapies, brand value, their impact on the market and view of the key opinion leaders.

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Metastatic Urothelial Carcinoma Epidemiology
The epidemiology section covers detailed insights into the historical, and current Metastatic Urothelial Carcinoma patient pool and forecasted epidemiology trends for every seven major countries (7MM) from 2019 to 2032.

The Report Covers the Metastatic Urothelial Carcinoma Epidemiology Segmented as -
• Diagnosed Incident Population of Urothelial Carcinoma
• Total Cases of Locally Advanced/Metastatic Urothelial Carcinoma
• Severity-specific Diagnosed Incident Population of Urothelial Carcinoma
• Age-specific Diagnosed Incident Population of Urothelial Carcinoma
• Gender-specific Diagnosed Incident Population of Urothelial Carcinoma
• Tumor (T) stage-specific Diagnosed Incident Population of Urothelial Carcinoma
• Metastatic stage-specific Diagnosed Incident Population of Urothelial Carcinoma

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Metastatic Urothelial Carcinoma Drugs Uptake and Pipeline Development Activities
The drugs' uptake section focuses on the rate of uptake of the potential drugs recently launched in the Metastatic Urothelial Carcinoma market or expected to be launched during the study period. The analysis covers the market share by Metastatic Urothelial Carcinoma drugs, patient uptake by therapies, and sales of each drug.

The report's drugs uptake section helps in understanding the drugs with the most rapid uptake and the reasons behind the maximal use of new drugs. It allows the comparison of the drugs based on market share and size, which again will be helpful in investigating factors important in understanding the market dynamics and in making financial and regulatory decisions.

The report also covers the Metastatic Urothelial Carcinoma Pipeline Development Activities and provides valuable insights about different therapeutic candidates in Phase II and Phase III stages and the key companies in the market involved in developing targeted therapeutics. It also analyzes recent developments such as collaborations, acquisitions, mergers, licensing patent details, and other information for emerging therapies.

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Metastatic Urothelial Carcinoma Therapeutics Assessment
Urothelial Carcinoma, also known as transitional cell carcinoma (TCC), is characterized by cancer beginning in the urothelial cells lining the bladder, it is one of the most common forms of bladder cancer (BC). Treatment for metastatic form of Urothelial Carcinoma can be employed in different classes of chemotherapy, immunotherapy, radiation therapy, target-specific therapy, and surgical treatment. Metastatic Urothelial Carcinoma has shown poor survival when treated with chemotherapy; however, due to the advancements in the treatment of new immunotherapies, more alternatives are available.

Chemotherapy majorly forms the first line of treatment mainly comprising platinum-based products. Cisplatin-based chemotherapy is a chief product in the list of chemotherapeutics. The commonly used cisplatin regimens include MVAC (methotrexate, vinblastine, doxorubicin, cisplatin) or GC (gemcitabine and cisplatin). Cisplatin is followed by Carboplatin for therapeutic regimens, such as M-CAVI (methotrexate, carboplatin, and vinblastine). A few nonplatinum regimens include gemcitabine with a taxane (either paclitaxel or docetaxel) rather than platinum. Single-agent chemotherapy also holds importance in the treatment routine, including Gemcitabine, Vinflunine, and Ifosfamide.

The major class of treatment also comprises Immunotherapy, which helps the patient's own immune system to recognize and destroy cancer cells. Developments in this domain have led to the development of immune checkpoint inhibitors (ICIs) targeting the programmed death (PD-1/PDL-1) pathway. Immunotherapy is used in platinum-ineligible or refractory cases. The market holds Atezolizumab (Tecentriq), Pembrolizumab (Keytruda), Nivolumab (Opdivo), Durvalumab (Imfinzi), and Avelumab (Bavencio) as approved products targeting PD-1/PDL-1 pathway.

Several major pharma and biotech companies are actively involved in the development of therapies targeting Metastatic Urothelial Carcinoma. Among these, several companies have progressed their drug candidates for Metastatic Urothelial Carcinoma to the most advanced stages of clinical development, notably in Phase II trials. One such company is PharmaMar, recognized for its pioneering efforts in advancing innovative treatments for this aggressive form of cancer. These companies collectively represent a robust landscape of research and development endeavors aimed at addressing the urgent medical needs of patients grappling with Metastatic Urothelial Carcinoma.

Metastatic Urothelial Carcinoma pipeline possesses several potential drugs that are expected to be launched in the near future. Ramucirumab (Eli Lilly), Infigratinib (QED Therapeutics) are currently in phase III stage of development followed by Rogaratinib (Bayer) in the phase II/III developmental stage, and Pemigatinib (Incyte Corporation), Sacituzumab govitecan (Immunomedics), NKTR-214 (Nektar Therapeutics/Bristol-Myers Squibb), RX-3117 (Rexahn Pharmaceuticals) in phase II clinical stage.

Leading Companies in the Metastatic Urothelial Carcinoma Therapeutics Market Include
Some of the key companies in the Urothelial Carcinoma Market include PharmaMar, Ectin Research AG, Exelixis, Eli Lilly and Company, Merck Sharp & Dohme LLC, Astellas Pharma Inc, Seagen Inc., Shanghai Miracogen Inc., and Advaxis, Inc., and many others.

Emerging and Marketed Metastatic Urothelial Carcinoma Therapies Covered in the Report Include
• MFA 370: Ectin Research AG
• XL 092: Exelixis
• Lurbinectedin: PharmaMar
And Many More

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Table of Content (TOC)
1. Key Insights
2. Executive Summary
3. Metastatic Urothelial Carcinoma Competitive Intelligence Analysis
4. Metastatic Urothelial Carcinoma Market Overview at a Glance
5. Metastatic Urothelial Carcinoma Background and Overview
6. Metastatic Urothelial Carcinoma Patient Journey
7. Metastatic Urothelial Carcinoma Epidemiology and Patient Population
8. Metastatic Urothelial Carcinoma Treatment Algorithm, Current Treatment, and Medical Practices
9. Metastatic Urothelial Carcinoma Unmet Needs
10. Key Endpoints of Metastatic Urothelial Carcinoma Treatment
11. Metastatic Urothelial Carcinoma Marketed Products
12. Metastatic Urothelial Carcinoma Emerging Therapies
13. Metastatic Urothelial Carcinoma Seven Major Market Analysis
14. Attribute Analysis
15. Metastatic Urothelial Carcinoma Market Outlook (7 major markets)
16. Metastatic Urothelial Carcinoma Access and Reimbursement Overview
17. KOL Views on the Metastatic Urothelial Carcinoma Market.
18. Metastatic Urothelial Carcinoma Market Drivers
19. Metastatic Urothelial Carcinoma Market Barriers
20. Appendix
21. DelveInsight Capabilities
22. Disclaimer
*The table of contents is not exhaustive; the final content may vary.

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