Global CAR-T Cell Therapy Market: Trends, Growth Forecasts, and Key Players 2024-2031

Report Overview
Global CAR-T Cell Therapy Market is expected to grow at a CAGR of 9.1% during the forecast period 2024-2031.

Chimeric antigen receptor T-cell therapy, often referred to as CAR-T therapy, is a treatment method where a patient's T cells are genetically modified to produce chimeric antigen receptor (CAR) T-cells. These engineered cells are designed to recognize and more effectively eliminate cancer cells. CARs are proteins that enable T cells to identify an antigen present on specific tumor cells.

Even months after the infusion process, CAR-T cells may persist in the body and help prevent the recurrence of cancer cells. CAR-T cell therapy is an extremely promising emerging treatment for cancer patients and is increasingly favored over traditional methods such as chemotherapy, surgery, and radiation therapy.

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CAR-T Cell Therapy Market Trends

The CAR-T Cell Therapy Market is experiencing significant growth globally, primarily due to the rising prevalence of cancer and the urgent need for effective treatments. According to the World Health Organization, the global cancer burden reached 18.1 million new cases and 9.6 million deaths in 2018, with approximately one in five men and one in six women worldwide developing cancer during their lifetime.

Advancements in technology aimed at treating cancer, increased research and development investments by key industry players, government initiatives supporting treatment and research, and a growing population resistant to traditional chemotherapy and radiation therapies are driving market expansion.

For example, in May 2019, Ziopharm Oncology Inc., a leading immuno-oncology company focused on next-generation cell and gene therapies, secured an exclusive licensing agreement with the National Cancer Institute (NCI). This agreement allows for the development and commercialization of cell therapies for cancer using Ziopharm's Sleeping Beauty platform, demonstrating promising strides in the field.

Similarly, in April 2019, Allogene Therapeutics Inc., a pioneer in developing allogeneic CAR T (AlloCAR T) therapies for cancer, released preclinical study results of ALLO-715 in Molecular Therapy. ALLO-715, an AlloCAR T therapy targeting B-cell maturation antigen (BCMA), shows potential as a novel treatment for multiple myeloma and other BCMA-positive malignancies.

However, stringent regulations, potential neurological side effects, and the high cost of treatment pose challenges to market advancement. These factors need careful consideration to ensure continued progress in the field of CAR-T cell therapy.

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Market Segmentation

By Target Antigen
CD 19
CD 20
GD2
CD22
CD30
CD33
HER1
HER2
Meso
EGFRV III

By Therapeutic Application
Acute Lymphoblastic Leukemia (ALL)
Chronic lymphocytic leukemia (CLL)
Non-Hodgkin lymphoma
Acute myeloid leukemia (AML)
Neuroblastoma
Multiple myeloma (MM)

Market Key Players
Major players are Pfizer, Inc. Novartis AG, Juno Therapeutics, Inc. (Celgene Corporation), Kite Pharma, Inc. (Gilead Sciences Inc.), bluebird bio (Celgene Corporation), Bellicum Pharmaceuticals, Inc, Immune Therapeutics, Inc, Cellectis, Sorrento Therapeutics, Inc and CARsgen Therapeutics, Ltd.

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