Complicated Urinary Tract Infections (cUTIs) Market Poised for Extraordinary Growth During the Forecast Period (2023-32), Asserts DelveInsight | Allecra Therapeutics (EXBLIFEP (cefepime/enmetazobactam)), Iterum, Venatorx, Nabriva, Wockhardt, MerLion

The Complicated Urinary Tract Infections (cUTIs) market is dynamically evolving with the development of novel antimicrobial agents, increased focus on antibiotic stewardship, and advancements in diagnostic technologies, offering the potential for more targeted and effective treatment options. Growing awareness of antibiotic resistance and the demand for alternative therapies are driving innovation and shaping the landscape of cUTI management, fostering improved patient outcomes.

DelveInsight's "Complicated Urinary Tract Infections (cUTIs) Market Insights, Epidemiology, and Market Forecast 2032" report delivers an in-depth understanding of the disease, historical and forecasted epidemiology, as well as the Complicated Urinary Tract Infections Market Size and Share in the seven major markets (7MM) (i.e., the United States, EU4 (Germany, Spain, Italy, France), the United Kingdom and Japan).

The market report covers emerging drugs, treatment practices, market share of individual Complicated Urinary Tract Infections therapies, and current & forecasted market size from 2019 to 2032. It also evaluates the current Complicated Urinary Tract Infections treatment practice/algorithm, market drivers & barriers, and unmet medical needs to curate the best of opportunities and assess the underlying potential of the market.

Complicated Urinary Tract Infections (cUTIs): An Overview
Complicated Urinary Tract Infection (cUTI), a type of urinary tract infection (UTI) involving either the bladder or kidneys, is a symptomatic urinary infection that occurs in individuals with functional or structural abnormalities of the genitourinary tract, that predispose the patient to persistent infection, recurrent infection or treatment failure. UTIs are basically categorized as uncomplicated or complicated depending on the severity of infection. These are caused by a wide range of pathogens, including gram-negative and gram-positive bacteria as well as fungi.

Complicated UTIs occur when certain predisposing factors are present. These factors generally include obstructed urinary flow due to congenital causes, prostatic obstruction or urinary stones; incomplete bladder emptying due to anatomic (prostatic or urethral) or neurogenic (congenital or acquired spinal cord abnormalities) reasons; vesicoureteral reflux, foreign bodies in the urinary tract (instruments, catheters, drainage tubes); systemic illness such as diabetes; pregnancy and males participating in anal intercourse.

Complicated Urinary Tract Infections (cUTIs) Market Key Facts
• In 2021, the total Complicated Urinary Tract Infections (cUTIs) market size was USD 1,868.1 Million in the 7MM, which is expected to rise during the study period (2019-2032).
• The total Complicated Urinary Tract Infections (cUTIs) market size in the United States was USD 962.3 M in 2021.
• In EU-5, the total Complicated Urinary Tract Infections (cUTIs) market size was USD 642.0 M in 2021.
• In Japan, the Complicated Urinary Tract Infections (cUTIs) market size was USD 263.9 M in 2021.
• According to DelveInsight, in the year 2021, the total diagnosed incident cases of cUTI were 3.43 M in the United States.
• The highest number of total incident cases of cUTI was observed in Germany among the EU5 countries, with 0.87 M cases in 2021.
• In the year 2021, the total number of diagnosed incident cases of cUTI was 1.28 M in Japan.

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Complicated Urinary Tract Infections (cUTIs) Market
The market outlook section of the report helps to build a detailed comprehension of the historical, current, and forecasted market size by analyzing the impact of current and emerging Complicated Urinary Tract Infections therapies in the market. It also provides a detailed assessment of the Complicated Urinary Tract Infections market drivers & barriers, unmet needs, and emerging technologies.

The report gives complete details of the market trend for each marketed Complicated Urinary Tract Infections drug and late-stage pipeline therapies by evaluating their impact based on the annual cost of therapy, inclusion and exclusion criteria, mechanism of action (MOA), competition with other therapies, brand value, their impact on the market and view of the key opinion leaders.

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Complicated Urinary Tract Infections (cUTIs) Epidemiology
The epidemiology section covers detailed insights into the historical, and current Complicated Urinary Tract Infections patient pool and forecasted epidemiology trends for every seven major countries (7MM) from 2019 to 2032.

The Report Covers the Complicated Urinary Tract Infections Epidemiology Segmented as -
• Total Diagnosed-incident Cases of Complicated Urinary Tract Infection
• Total Age-specific Cases of Complicated Urinary Tract Infection
• Total Pathogen-specific Cases of Complicated Urinary Tract Infection
• Total Treated Cases (across lines) of Complicated Urinary Tract Infection

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Complicated Urinary Tract Infections (cUTIs) Drugs Uptake and Pipeline Development Activities
The drugs' uptake section focuses on the rate of uptake of the potential drugs recently launched in the Complicated Urinary Tract Infections market or expected to be launched during the study period. The analysis covers the market share by Complicated Urinary Tract Infections drugs, patient uptake by therapies, and sales of each drug.

The report's drugs uptake section helps in understanding the drugs with the most rapid uptake and the reasons behind the maximal use of new drugs. It allows the comparison of the drugs based on market share and size, which again will be helpful in investigating factors important in understanding the market dynamics and in making financial and regulatory decisions.

The report also covers the Complicated Urinary Tract Infections Pipeline Development Activities and provides valuable insights about different therapeutic candidates in Phase II and Phase III stages and the key companies in the market involved in developing targeted therapeutics. It also analyzes recent developments such as collaborations, acquisitions, mergers, licensing patent details, and other information for emerging therapies.

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Complicated Urinary Tract Infections (cUTIs) Therapeutics Assessment
The choice of treatment options for complicated UTIs depends on the severity of cUTI and encompasses three goals: management of the urological abnormality, antimicrobial therapy and supportive care when needed. Oral agents can be considered in patients who are clinically stable (either as initial therapy or as step-down therapy after IV). Trimethoprim-sulfamethoxazole and fluoroquinolones have excellent penetration into genitourinary tissue and are preferred oral agents for complicated UTI. Principles for treating recurrent complicated UTIs include early use of broad-spectrum antibiotics.

Recommended antibiotics options include fluoroquinolones, amoxicillin-clavulanate, third-generation cephalosporins with antipseudomonal activities, such as ceftazidime (Fortaz) or cefoperazone (Cefobid), cefepime (Maxipime), aztreonam (Azactam), imipenemcilastatin (Primaxin) or the combination of an antipseudomonal penicillin (ticarcillin, mezlocillin, piperacillin) with an aminoglycoside. Some of the approved antibiotics for cUTIs include ZEMDRI, Vabomere, Avycaz, Zerbaxa etc.

Several major pharma and biotech companies are actively developing therapies for Complicated Urinary Tract Infections. Currently, Spero Therapeutics is leading the therapeutics market with its Complicated Urinary Tract Infections drug candidates in the most advanced stage of clinical development.

On February 27, 2024, Allecra Therapeutics ("Allecra") announced that the US FDA has approved EXBLIFEP® (cefepime/enmetazobactam), as a treatment for complicated urinary tract infections (cUTIs), including pyelonephritis, in patients 18 years and older. Allecra has also received a five-year marketing exclusivity extension from the FDA as part of the Generating Antibiotic Incentives Now Act (GAIN Act). The GAIN Act, enacted by the U.S. Congress, incentivizes the creation of new anti-infective therapeutics by providing benefits to manufacturers of Qualified Infectious Disease Products (QIDPs).

Leading Companies in the Complicated Urinary Tract Infections (cUTIs) Therapeutics Market Include
• Spero Therapeutics
• Iterum Therapeutics
• Venatorx Pharmaceuticals, Inc.
• Nabriva Therapeutics
• Allecra Therapeutics
• Wockhardt
• MerLion Pharmaceuticals
And Many Others

Emerging and Marketed Complicated Urinary Tract Infections (cUTIs) Therapies Covered in the Report Include
• Tebipenem Pivoxil Hydrobromide: Spero Therapeutics
• Sulopenem: Iterum Therapeutics
• FEP-TAZ: Wockhardt
• Cefepime/AAI101 combination: Allecra
• S-649266: Shionogi
And Many More

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Table of Content (TOC)
1. Key Insights
2. Executive Summary
3. Complicated Urinary Tract Infections Competitive Intelligence Analysis
4. Complicated Urinary Tract Infections Market Overview at a Glance
5. Complicated Urinary Tract Infections Background and Overview
6. Complicated Urinary Tract Infections Patient Journey
7. Complicated Urinary Tract Infections Epidemiology and Patient Population
8. Complicated Urinary Tract Infections Treatment Algorithm, Current Treatment, and Medical Practices
9. Complicated Urinary Tract Infections Unmet Needs
10. Key Endpoints of Complicated Urinary Tract Infections Treatment
11. Complicated Urinary Tract Infections Marketed Products
12. Complicated Urinary Tract Infections Emerging Therapies
13. Complicated Urinary Tract Infections Seven Major Market Analysis
14. Attribute Analysis
15. Complicated Urinary Tract Infections Market Outlook (7 major markets)
16. Complicated Urinary Tract Infections Access and Reimbursement Overview
17. KOL Views on the Complicated Urinary Tract Infections Market.
18. Complicated Urinary Tract Infections Market Drivers
19. Complicated Urinary Tract Infections Market Barriers
20. Appendix
21. DelveInsight Capabilities
22. Disclaimer
*The table of contents is not exhaustive; the final content may vary.

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