Corneal Endothelial Dystrophy Market is Expected to Showcase a Significant Growth During the Forecast Period (2023-2032), Predicts DelveInsight | Key Companies - Trefoil Therapeutics, Aerie Pharmaceuticals, Kowa Research Institute, Emmecell, Surrozen

The corneal endothelial dystrophy market is witnessing rapid evolution, driven by advancements in treatment options and diagnostic technologies. Novel therapeutics targeting specific molecular pathways are emerging, promising improved outcomes and potential disease modification. Additionally, innovative surgical techniques, like endothelial keratoplasty, offer precise and less invasive options for restoring corneal function, marking a shift towards more personalized and comprehensive care approaches.

DelveInsight's "Corneal Endothelial Dystrophy Market Insights, Epidemiology, and Market Forecast 2032" report delivers an in-depth understanding of the disease, historical and forecasted epidemiology, as well as the Corneal Endothelial Dystrophy Market Size and Share in the seven major markets (7MM) (i.e., the United States, EU4 (Germany, Spain, Italy, France), the United Kingdom and Japan).

The market report covers emerging drugs, treatment practices, market share of individual Corneal Endothelial Dystrophy therapies, and current & forecasted market size from 2019 to 2032. It also evaluates the current Corneal Endothelial Dystrophy treatment practice/algorithm, market drivers & barriers, and unmet medical needs to curate the best of opportunities and assess the underlying potential of the market.

Corneal Endothelial Dystrophy: An Overview
Corneal dystrophies are a group of rare genetic, often progressive, eye disorders in which abnormal material often accumulates in the clear (transparent) outer layer of the eye (cornea). There are more than 20 different types of corneal dystrophies.

Most cases of corneal dystrophy are inherited as an autosomal dominant trait with variable expressively. Posterior polymorphous forms of corneal dystrophy have autosomal dominance inheritance. Fuchs dystrophy may have autosomal dominant inheritance in some cases; in others, it may occur spontaneously for no apparent reason (sporadic). Congenital hereditary corneal dystrophy type II has autosomal recessive inheritance.

The symptoms of corneal dystrophy depend upon the type of corneal dystrophy. Some people experience no symptoms. In others, the build-up of material in the cornea causes it to become opaque (not clear). This leads to blurred vision or vision loss. Many people also experience corneal erosion which causes mild to severe pain in the eye, light sensitivity, and feeling like something is in the eye.

The presence of corneal endothelial dystrophy may be found incidentally during a routine eye examination. A diagnosis may be confirmed by a thorough clinical evaluation, a detailed patient history, and a variety of tests, such as a slit lamp examination, in which a special microscope (slit lamp) allows a physician to view the eye through high magnification. Some specific corneal dystrophies can be diagnosed with molecular genetic tests even before symptoms develop.

Corneal Endothelial Dystrophy Market Key Facts
• According to the study titled "Corneal Dystrophy" by Moshirfar et al., (2020) in the United States, less than 0.01% of Americans are affected by corneal dystrophy (CD). It also stated the findings of another study, which showed that around 530 persons out of a million in the United States have an endothelial-type CD. Both genders are equally affected by CD, although it has been shown that Fuchs CD is more common in females.
• As per the data published in the American Academy of Ophthalmology, in 2020, the exact prevalence of Posterior Polymorphous Corneal Endothelial Dystrophy (PPMD, PPCD) is not known, studies of the prevalence of corneal dystrophies in the US estimate that 60% of congenital corneal dystrophies have endothelial involvement. PPMD usually presents in early childhood or adolescence as clouding of the stroma that may cause blurred vision. Ocular diseases correlated with PPMD include secondary glaucoma and keratoconus.

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Corneal Endothelial Dystrophy Market
The market outlook section of the report helps to build a detailed comprehension of the historical, current, and forecasted market size by analyzing the impact of current and emerging Corneal Endothelial Dystrophy therapies in the market. It also provides a detailed assessment of the Corneal Endothelial Dystrophy market drivers & barriers, unmet needs, and emerging technologies.

The report gives complete details of the market trend for each marketed Corneal Endothelial Dystrophy drug and late-stage pipeline therapies by evaluating their impact based on the annual cost of therapy, inclusion and exclusion criteria, mechanism of action (MOA), competition with other therapies, brand value, their impact on the market and view of the key opinion leaders.

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Corneal Endothelial Dystrophy Epidemiology
The epidemiology section covers detailed insights into the historical, and current Corneal Endothelial Dystrophy patient pool and forecasted epidemiology trends for every seven major countries (7MM) from 2019 to 2032.

The Report Covers the Corneal Endothelial Dystrophy Epidemiology Segmented as -
• Prevalent Population of Corneal Endothelial Dystrophy
• Prevalent Population of Corneal Endothelial Dystrophy
• Diagnosed and Treatable Cases of Corneal Endothelial Dystrophy
• Type-specific Prevalent Population of Corneal Endothelial Dystrophy

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Corneal Endothelial Dystrophy Drugs Uptake and Pipeline Development Activities
The drugs' uptake section focuses on the rate of uptake of the potential drugs recently launched in the Corneal Endothelial Dystrophy market or expected to be launched during the study period. The analysis covers the market share by Corneal Endothelial Dystrophy drugs, patient uptake by therapies, and sales of each drug.

The report's drugs uptake section helps in understanding the drugs with the most rapid uptake and the reasons behind the maximal use of new drugs. It allows the comparison of the drugs based on market share and size, which again will be helpful in investigating factors important in understanding the market dynamics and in making financial and regulatory decisions.

The report also covers the Corneal Endothelial Dystrophy Pipeline Development Activities and provides valuable insights about different therapeutic candidates in Phase II and Phase III stages and the key companies in the market involved in developing targeted therapeutics. It also analyzes recent developments such as collaborations, acquisitions, mergers, licensing patent details, and other information for emerging therapies.

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Corneal Endothelial Dystrophy Therapeutics Assessment
As mentioned earlier, Fuchs' dystrophy is the most common type of corneal endothelial dystrophy. The early stage of Fuchs' dystrophy is treated with prescription eye drops (Muro 128, Sodium chloride eye drops) or ointments to reduce pain and swelling. However, significant corneal scarring may warrant a transplant. There are two options: a full corneal transplant or an endothelial keratoplasty (EK).

To date, no treatment is available to stop the progression of Schnyder corneal dystrophy. Phototherapeutic keratectomy can remove subepithelial crystals if they are affecting visual acuity. Penetrating keratoplasty can be performed in eyes with advanced disease, but the disease can recur in the graft.

Additionally, most cases of Posterior Polymorphous Corneal Dystrophy are asymptomatic, and these cases generally do not require treatment while the treatment for Congenital Hereditary Endothelial Dystrophy is mainly surgical either by penetrating keratoplasty (PK) or endothelial keratoplasty (EK).

Leading Companies in the Corneal Endothelial Dystrophy Therapeutics Market Include
• Trefoil Therapeutics
• Aerie Pharmaceuticals
• Kowa ResearchInstitute,Inc.
• Emmecell
• Surrozen
And Many Others

Emerging and Marketed Corneal Endothelial Dystrophy Therapies Covered in the Report Include
• TTHX1114: Trefoil Therapeutics
• Netarsudil mesylate: Aerie Pharmaceuticals
• Rhopressa (Netarsudil ophthalmic solution 0.02%): Price Vision Group
• Glanatec (K-321 solution): Kowa Company
And Many More

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Table of Content (TOC)
1. Key Insights
2. Executive Summary
3. Corneal Endothelial Dystrophy Competitive Intelligence Analysis
4. Corneal Endothelial Dystrophy Market Overview at a Glance
5. Corneal Endothelial Dystrophy Background and Overview
6. Corneal Endothelial Dystrophy Patient Journey
7. Corneal Endothelial Dystrophy Epidemiology and Patient Population
8. Corneal Endothelial Dystrophy Treatment Algorithm, Current Treatment, and Medical Practices
9. Corneal Endothelial Dystrophy Unmet Needs
10. Key Endpoints of Corneal Endothelial Dystrophy Treatment
11. Corneal Endothelial Dystrophy Marketed Products
12. Corneal Endothelial Dystrophy Emerging Therapies
13. Corneal Endothelial Dystrophy Seven Major Market Analysis
14. Attribute Analysis
15. Corneal Endothelial Dystrophy Market Outlook (7 major markets)
16. Corneal Endothelial Dystrophy Access and Reimbursement Overview
17. KOL Views on the Corneal Endothelial Dystrophy Market.
18. Corneal Endothelial Dystrophy Market Drivers
19. Corneal Endothelial Dystrophy Market Barriers
20. Appendix
21. DelveInsight Capabilities
22. Disclaimer
*The table of contents is not exhaustive; the final content may vary.

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About DelveInsight
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