Hemophilia A Market to Observe Impressive Growth During the Forecast Period (2023-2032), Evaluates DelveInsight | Alnylam, Novo Nordisk, ApcinteX, Bayer, BioMarin Pharmaceutical, Sinocelltech, Sanofi , Centessa, CSL Behring, Regeneron, Roche

The Hemophilia A Market is anticipated to evolve immensely in the coming years owing to the rise in the prevalent population of Hemophilia A, the rise in healthcare spending across the world, the expected entry of gene therapy, siRNA, and bispecific antibodies, and the expected readily uptake of recently approved therapies.

DelveInsight's "Hemophilia A Market Insights, Epidemiology, and Market Forecast 2032" report delivers an in-depth understanding of the disease, historical and forecasted epidemiology, as well as the Hemophilia A Market Size and Share in the seven major markets (7MM) (i.e., the United States, EU4 (Germany, Spain, Italy, France), the United Kingdom and Japan).

The market report covers emerging drugs, treatment practices, market share of individual Hemophilia A therapies, and current & forecasted market size from 2019 to 2032. It also evaluates the current Hemophilia A treatment practice/algorithm, market drivers & barriers, and unmet medical needs to curate the best of opportunities and assess the underlying potential of the market.

Hemophilia A: An Overview
Hemophilia A is a genetic bleeding disorder in which an individual lacks or has low levels of proteins named clotting factor VIII. Without enough factor VIII, the blood cannot clot properly to control bleeding. Although it is passed down from parents to children, about 1/3 of cases found have no previous family history.

It is caused by an inherited X-linked recessive trait, with the defective gene located on the X chromosome. Females have two copies of the X chromosome. So if the factor VIII gene on one chromosome does not work, the gene on the other chromosome can do the job of making enough factor VIII.

People with hemophilia A bleed longer than other people. Bleeds can occur internally, into joints and muscles, or externally, from minor cuts, dental procedures, or injuries. The frequency of the bleeds and the severity of those bleeds depends on how much FVIII a person produces naturally. Normal levels of FVIII range from 50% to 150%. Levels below 50% - or half of what is needed to form a clot - determine a person's symptoms.

Individuals with the severe form of hemophilia A can experience spontaneous bleeding into any organ system, including the kidneys, the gastrointestinal tract, and the brain (intracranial bleeding). Genitourinary and gastrointestinal bleeding may respectively cause blood in the urine (hematuria) and black or bloody stools (melena, hematochezia).

Hemophilia A Market Key Facts
• As per DelveInsight, the Hemophilia A Market size in the 7MM was USD 8,510 million in 2021, and it is projected to grow in the upcoming years at an immense CAGR.
• According to the estimates, the highest market size of Hemophilia A is from the United States in 2021.
• Among the EU5 countries, France has the maximum revenue share followed by the United Kingdom in 2021 while Spain has the lowest market share.
• The market size of Hemophilia A in Japan is USD 956 million in 2021.
• The total prevalent population of Hemophilia A in the 7MM comprised 45,149 cases in 2021.
• The total prevalent population of Hemophilia A in the United States is 14,146 in 2021.
• The United States contributed to the largest prevalent population of Hemophilia A, accounting for ~ 31% of the 7MM in 2021.
• In the EU5 countries, the diagnosed prevalence of Hemophilia A was found to be maximum in France, followed by the UK. While, the least number of cases were found in Spain, in 2021.

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Hemophilia A Market
The market outlook section of the report helps to build a detailed comprehension of the historical, current, and forecasted market size by analyzing the impact of current and emerging Hemophilia A therapies in the market. It also provides a detailed assessment of the Hemophilia A market drivers & barriers, unmet needs, and emerging technologies.

The report gives complete details of the market trend for each marketed Hemophilia A drug and late-stage pipeline therapies by evaluating their impact based on the annual cost of therapy, inclusion and exclusion criteria, mechanism of action (MOA), competition with other therapies, brand value, their impact on the market and view of the key opinion leaders.

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Hemophilia A Epidemiology
The epidemiology section covers detailed insights into the historical, and current Hemophilia A patient pool and forecasted epidemiology trends for every seven major countries (7MM) from 2019 to 2032.

The Report Covers the Hemophilia A Epidemiology Segmented as -
• Total Diagnosed Prevalent Pool of Hemophilia A in the 7MM [2019-2032]
• Treated Prevalent Pool of Hemophilia A in the 7MM [2019-2032]
• Severity-specific Prevalent Pool of Hemophilia A in the 7MM [2019-2032]
• Inhibitor-specific Prevalent Pool of Hemophilia A in the 7MM [2019-2032]

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Hemophilia A Drugs Uptake and Pipeline Development Activities
The drugs' uptake section focuses on the rate of uptake of the potential drugs recently launched in the Hemophilia A market or expected to be launched during the study period. The analysis covers the market share by Hemophilia A drugs, patient uptake by therapies, and sales of each drug.

The report's drugs uptake section helps in understanding the drugs with the most rapid uptake and the reasons behind the maximal use of new drugs. It allows the comparison of the drugs based on market share and size, which again will be helpful in investigating factors important in understanding the market dynamics and in making financial and regulatory decisions.

The report also covers the Hemophilia A Pipeline Development Activities and provides valuable insights about different therapeutic candidates in Phase II and Phase III stages and the key companies in the market involved in developing targeted therapeutics. It also analyzes recent developments such as collaborations, acquisitions, mergers, licensing patent details, and other information for emerging therapies.

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Hemophilia A Therapeutics Assessment
Mostly the available treatments for hemophilia A focus on replacing the missing protein, FVIII (8), so the patient can form a clot, and reduce or eliminate the bleeds associated with the disorder. Treatments that work to prevent bleeding through new mechanisms have recently come to the market or are under development. People with hemophilia A have several different medication options for treatment.

Generally, Hemophilia A patients are provided with "On Demand" and "Prophylaxis" treatment. But Prophylaxis treatment option has gained importance in comparison to the on-demand treatment options.

The mainstay treatment option has long been FVIII replacement therapy. Initially, FVIII replacement was accomplished by donated whole blood, subsequently by plasma, and currently by recombinant human FVIII (rFVIII) replacement therapies, which revolutionized the treatment of Hemophilia A.

Some of the leading pharma giants in the Hemophilia A Market such as BioMarin Pharmaceutical, Roche (Spark Therapeutics), ApcinteX, Novo Nordisk, Sanofi (Genzyme), Alnylam Pharmaceuticals, Pfizer, Sangamo Therapeutics, Bayer, Ultragenyx Pharmaceutical, and others are actively involved the development of new therapies. Currently, Novo Nordisk is leading the therapeutics market with its Hemophilia A drug candidates in the most advanced stage of clinical development.

Leading Companies in the Hemophilia A Therapeutics Market Include
Alnylam Pharmaceuticals, ApcinteX, Bayer, BioMarin, BioMarin Pharmaceutical, Catalyst Biosciences, Centessa Pharmaceuticals, Chia Tai Tianqing Pharmaceutical Group, Chugai Pharmaceutical, CSL Behring, Dimension Therapeutics, Expression Therapeutics, LLC, Hoffmann-La Roche, Intellia Therapeutics, Kymab, Novo Nordisk, Octapharma, Pfizer, Poseida Therapeutics, Regeneron Pharmaceuticals, Roche (Spark Therapeutics), Sangamo Therapeutics, Sanofi Genzyme, Shire, Sinocelltech Ltd., Spark Therapeutics, Staidson Beijing BioPharmaceuticals, Ultragenyx Pharmaceutical, and many others.

Emerging and Marketed Hemophilia A Therapies Covered in the Report Include
• AGN-193408: Allergan
• BIVV001: Sanofi in collaboration with Sobi
• Concizumab: Novo Nordisk
• Fitusiran: Alnylam Pharmaceuticals/Sanofi Genzyme
• Marstacimab: Pfizer
• OCTA101: Octapharma
• Valoctocogene roxaparvovec: BioMarin Pharmaceuticals
And Many More

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Table of Content (TOC)
1. Key Insights
2. Executive Summary
3. Hemophilia A Competitive Intelligence Analysis
4. Hemophilia A Market Overview at a Glance
5. Hemophilia A Background and Overview
6. Hemophilia A Patient Journey
7. Hemophilia A Epidemiology and Patient Population
8. Hemophilia A Treatment Algorithm, Current Treatment, and Medical Practices
9. Hemophilia A Unmet Needs
10. Key Endpoints of Hemophilia A Treatment
11. Hemophilia A Marketed Products
12. Hemophilia A Emerging Therapies
13. Hemophilia A Seven Major Market Analysis
14. Attribute Analysis
15. Hemophilia A Market Outlook (7 major markets)
16. Hemophilia A Access and Reimbursement Overview
17. KOL Views on the Hemophilia A Market.
18. Hemophilia A Market Drivers
19. Hemophilia A Market Barriers
20. Appendix
21. DelveInsight Capabilities
22. Disclaimer
*The table of contents is not exhaustive; the final content may vary.

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About DelveInsight
DelveInsight is a leading Business Consultant and Market Research firm focused exclusively on life sciences. It supports Pharma companies by providing comprehensive end-to-end solutions to improve their performance.

This release was published on openPR.