Oligonucleotide Synthesis, Modification, and Purification Services Market Future Scope and Latest Trends Analysis Report

Oligonucleotide Synthesis, Modification, and Purification Services Market worth $7.83 Billion by 2031 - Exclusive Report by InsightAce Analytic

InsightAce Analytic Pvt. Ltd. announces the release of a market assessment report on the " Global Oligonucleotide Synthesis, Modification and Purification Services Market Oligonucleotide Mfg. Type (Antisense Oligonucleotides, siRNA, miRNA, And Other Oligonucleotides), Applications (Research And Diagnostic, Therapeutic, And Contract Manufacturing (OEM)), Operation Scale (Large-Scale Oligonucleotide Synthesis, Intermediate-Scale Oligonucleotide Synthesis, And Small-Scale Oligonucleotide Synthesis), Therapeutic Areas (Oncological Disorders, Eye Disorders, Metabolic Disorders, Autoimmune Disorders, And Other Therapeutic Areas), End-users (Pharmaceutical & Biotechnology Companies, Hospitals & Diagnostic Laboratories, Contract Research Organizations (Cros) And Contract Manufacturing Organizations (Cmos), And Academic Research Institutes) - Trends, Industry Competition Analysis, Revenue, and Forecast till 2030."
According to the latest research by InsightAce Analytic, the global oligonucleotide synthesis, modification, and purification services market was valued at 1.77 Billion in 2022 and is predicted to reach 7.83 Billion by the year 2031 at an 18.08 % CAGR during the forecast period for 2023-2031.
Major market players operating in the oligonucleotide synthesis, modification, and purification services market include Ajinomoto Bio-Pharma Services, Integrated DNA Technologies, Kaneka Eurogentec, LGC Biosearch Technologies, Microsynth, MilliporeSigma, BioSpring, CordenPharma, Nitto Denko Avecia, TriLink Biotechnologies, Eurofins Scientific SE, Thermo Fisher Scientific Inc., Agilent Technologies, Inc., GE Healthcare, GeneDesign, Inc., Bio-synthesis Inc., ATDBio Ltd, Burkert UK Limited, Almac Group, and Other Prominent Players.

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In molecular biology, biochemistry, and medicine, there has been a recent surge in interest in using modified oligoribonucleotides. Oligonucleotides are short DNA or RNA molecules with a single strand. PCR, real-time PCR, sequencing, site-directed mutagenesis, single nucleotide polymorphism (SNP) assays, microarrays, and numerous therapeutic applications utilize oligonucleotides synthesized from DNA or RNA using solid-phase synthesis. For many years, chemically modified oligonucleotides have been the subject of extensive research for developing novel antisense and siRNA therapies. To manufacture innovative vaccines and pharmaceuticals on time, businesses need more robust and dependable tools for characterizing and monitoring oligonucleotide and mRNA products.
Factors such as the rising demand for custom, high-quality oligos for NGS applications, advancements in synthesis and purification technologies, rising product launches by market players, high prevalence of chronic and genetic disorders, increasing geriatric population, rising custom oligo synthesis services, rising R&D activities in biotechnology firms for improving oligo synthesis and purification processes, and growing demand for personalized medicines are driving the market. In addition, expanding manufacturing facilities and strategies such as partnerships, mergers, and agreements by market participants are anticipated to boost market growth in the coming days. For example, in February 2018, STA Pharmaceutical Co. (China), a WuXi AppTec group company, and Regulus Therapeutics (US) signed a collaboration agreement for research and mid-scale non-GMP/cGMP manufacturing involving oligonucleotide synthesis. In addition, CordenPharma International and GE Healthcare's Dharmacon division collaborated in June 2017 to develop an end-to-end solution for oligonucleotide-based drug discovery.
However, high costs associated with the purification process, complex manufacturing procedures, oligo-degradation in generic research, and in-house development of oligonucleotides may impede the growth of the global oligonucleotide synthesis, modification and purification services market.
Geographically, North America is anticipated to hold the largest share of this market throughout the forecast period, followed by Europe. Due to improved healthcare infrastructures and the increasing use of oligonucleotides to develop novel drug therapies, Europe is anticipated to grow significantly in this market.
Key Developments In The Market:
• In Oct 2021, TriLink BioTechnologies stated that it plans to provide EyeGene, Inc. with its CleanCap® mRNA capping process and the modified nucleoside, uridine triphosphate, for the manufacturing of EyeGene's mRNA COVID-19 vaccine. This cooperation with EyeGene is anticipated to be the first clinical-stage initiative to utilise TriLink's GMP-grade modified uridine triphosphate designed for further processing.
• In June 2021, Thermo Fisher Scientific teamed up to build end-to-end procedures for complicated oligonucleotide and mRNA products. This collaboration combines the University of Sheffield's research expertise with Thermo Fisher's sample preparation, liquid chromatography (LC), high-resolution accurate-mass (HRAM), mass spectrometry (MS), and data interpretation software technologies to develop streamlined analytical workflows and robust fit-for-purpose processes.
• In January 2021, MilliporeSigma (US) acquired AmpTec, a leading Germany-based mRNA contract development and manufacturing organization (CDMO). The deal strengthens MilliporeSigma's capabilities to develop and manufacture mRNA for its customers for use in vaccines, treatments, and diagnostics applicable in Covid-19 and many other diseases.
• In September 2019, GeneDesign (Japan) acquired Ajinomoto Bio-Pharma Services, becoming part of the contract development and manufacturing organization (CDMO). The integration of GeneDesign's services offerings with Aji Bio-Pharma's small and large molecule capabilities in the U.S., Belgium, and India strengthens the CDMO's capabilities.
• In 2019, Integrated DNA Technology (US) launched 'oPools- oligo pools', a pool of high-quality DNA oligonucleotides with 350 nucleotides in length.
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Market Segments
Global Oligonucleotide Synthesis, Modification, and Purification Services Market, by By Oligonucleotide mfg. Types, 2022-2030 (Value US$ Bn)
• Antisense Oligonucleotides
• siRNA
• shRNA
• miRNA
• Aptamers
• Primers
• Probes
• Others (Adapters for NSG)

Global Oligonucleotide Synthesis, Modification, and Purification Services Market, by Applications, 2022-2030 (Value US$ Bn)
• Research and Diagnostic
o PCR
o qPCR/RTqPCR
o Sequencing
o Gene Synthesis
o Other Research Applications
• Therapeutic
o RNAi Oligonucleotide-based Therapies
o DNA/Antisense oligonucleotide-based Therapies
o Immunotherapy (CpG Oligonucleotide-based Therapies)
o Nucleic Acid Aptamer
• Contract Manufacturing

Global Oligonucleotide Synthesis, Modification, and Purification Services Market, by Operation Scale, 2022-2030 (Value US$ Bn)
• Large-Scale Oligonucleotide Synthesis
• Intermediate-Scale Oligonucleotide Synthesis
• Small-Scale Oligonucleotide Synthesis
Global Oligonucleotide Synthesis, Modification, and Purification Services Market, by Therapeutic Areas, 2022-2030 (Value US$ Bn)
• Oncological Disorders
• Eye Disorders
• Metabolic Disorders
• Autoimmune Disorders
• Other Therapeutic Areas
Global Oligonucleotide Synthesis, Modification, and Purification Services Market, by End-Users, 2022-2030 (Value US$ Bn)
• Pharmaceutical & Biotechnology Companies
• Hospitals & Diagnostic Laboratories
• Contract research organisations (CROs) and contract manufacturing organisations (CMOs)
• Academic Research Institutes
Global Oligonucleotide Synthesis, Modification, and Purification Services Market, by Region, 2022-2030 (Value US$ Bn)
• North America
• Europe
• Asia Pacific
• Latin America
• Middle East & Africa
North America Oligonucleotide Synthesis, Modification, and Purification Services Market, by Country, 2022-2030 (Value US$ Bn)
• U.S.
• Canada
Europe Oligonucleotide Synthesis, Modification, and Purification Services Market, by Country, 2022-2030 (Value US$ Bn)
• Germany
• France
• Italy
• Spain
• Russia
• Rest of Europe
Asia Pacific Oligonucleotide Synthesis, Modification, and Purification Services Market, by Country, 2022-2030 (Value US$ Bn)
• India
• China
• Japan
• South Korea
• Australia & New Zealand
Latin America Oligonucleotide Synthesis, Modification, and Purification Services Market, by Country, 2022-2030 (Value US$ Bn)
• Brazil
• Mexico
• Rest of Latin America
Middle East & Africa Oligonucleotide Synthesis, Modification, and Purification Services Market, by Country, 2022-2030 (Value US$ Bn)
• GCC Countries
• South Africa
• Rest of Middle East & Africa
Why should buy this report:
 To receive a comprehensive analysis of the prospects for the global oligonucleotide synthesis, modification, and purification services market
 To receive an industry overview and future trends of the oligonucleotide synthesis, modification, and purification services market
 To analyze the oligonucleotide synthesis, modification, and purification services market drivers and challenges
 To get information on the oligonucleotide synthesis, modification, and purification services market size value (US$ Mn) forecast to 2030
 Major Investments, Mergers & Acquisition in the oligonucleotide synthesis, modification, and purification services market industry

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Other Related Reports Published by InsightAce Analytic:
Global mRNA Extraction and Purification Market
Global Antibody Purification Services Market
Global Antisense Oligonucleotide Therapeutics Market
Global mRNA Synthesis and Manufacturing Services Market

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