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Immune Cell Engineering Market is Estimated to Witness High Growth by Size, Share, forecast 2024-2031|Thermo Fisher Scientific Inc., Merck KGaA, Danaher Corporation

02-05-2024 07:30 AM CET | Health & Medicine

Press release from: Coherent Market Insights

Immune Cell Engineering Market is Estimated to Witness High

Market Overview:

Immune cell engineering involves genetic modification of immune cells such as T cells, NK cells, and dendritic cells to enhance their ability to target and kill cancer cells. These engineered immune cells have applications in disease treatments such as cancer, infectious diseases, and autoimmune disorders.

Market Dynamics:

The immune cell engineering market is expected to witness significant growth over the forecast period owing to rising adoption of cell therapies for treatment of various chronic diseases and increasing research activities in the field of gene therapies and regenerative medicines. According to the report by Alliance for Regenerative Medicine, 165 cell therapy clinical trials were ongoing in 2020, demonstrating a growth of 25% from the previous year. Furthermore, increasing funding from both private and public organizations is also expected to fuel market growth between 2024 and 2031. For instance, the National Institutes of Health invested over US$ 1.5 billion in gene therapy research in 2020.

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Top Companies Covered In This Report: Thermo Fisher Scientific Inc., Merck KGaA, Danaher Corporation, Lonza, Miltenyi Biotec, Takara Bio Inc., Sartoroius CellGenix GmbH, FUJIFILM Irvine Scientific, Agilent Technologies, Inc., Bio-Techne, Bio-Rad Laboratories, Inc., Becton, Dickinson and Company, Charles River Laboratories, Creative Bioarray, Sartorius AG, Novogene Co, Ltd., AGC Biologics, Catalent, Inc., WuXi AppTec, Discovery Life Sciences

Market Segmentation:

By Cell Type
T Cells
NK Cells
Dendritic Cells
Tumor Cells
Stem Cells
Others

By Product
Consumables
Instruments
Software

By Disease Indication
Cardiovascular Diseases
Respiratory Diseases
Infectious Diseases
Cancer
Neurological Diseases
Others

By Application
Research Applications
Cell Therapy & Regenerative Medicine
Others

By End User
Pharmaceutical & Biotechnology Companies
Hospitals & Clinics
Academic & Research Institutes
Cell Banks
Others

Geographically, the detailed analysis of consumption, revenue, Immune Cell Engineering Market share, growth rate, etc. of the following regions:

» North America (United States, Canada, and Mexico)
» Europe (Germany, France, UK, Russia, Italy)
» Asia-Pacific (China, Japan, Korea, India, and Southeast Asia)
» Latin America (Brazil, Argentina, Colombia)
» Middle East and Africa (Saudi Arabia, UAE, Egypt, Nigeria, and South Africa)

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Increasing Investment in Cell-Based Research Driving Growth in the Immune Cell Engineering Market

The global immune cell engineering market has witnessed significant growth in recent years due to increasing investments made by both public and private investors into cell-based research. Large biotechnology and pharmaceutical companies have poured billions of dollars into developing novel cell therapies to treat cancer, infectious diseases, and autoimmune disorders. This sustained funding has allowed for advancements in T-cell engineering technologies such as chimeric antigen receptor T-cell (CAR-T) therapy. Several CAR-T therapies have gained regulatory approval and many more candidates are progressing through clinical trials. Additional cell types being engineered include NK cells, dendritic cells, and regulatory T cells with promising early data. As the potential for commercialization increases, venture capital firms have also allocated larger sums to support both early and late-stage immune cell engineering companies. This influx of capital has accelerated research activities and expanded the industrial manufacturing capacity needed to develop these complex living drug products.

Stringent Regulatory Requirements Pose a Challenge for Commercialization of Immune Cell Therapies

While the immune cell engineering field continues to see technological and clinical progress, commercialization of these novel treatments faces considerable regulatory hurdles. Cell therapies are classified as gene therapies by many regulatory bodies which require extensive preclinical testing and clinical trials to confirm safety and efficacy. Given the personalized nature and complex manufacturing processes involved in engineering immune cells, regulators scrutinize quality control, product characterization, and long-term safety profiles. Additional requirements relate to facilities, equipment, and personnel needed for good manufacturing practices of living drugs. Navigating this lengthy regulatory pathway has proven challenging for some companies and delayed time to market for promising candidates. High development costs and investment required also increase the commercial risks for both small biotechs and large pharmaceutical firms. However, health agencies are getting more experience in evaluating such therapies which may help streamline the review process over time.

Opportunities in Engineering Immune Cells for Targeting Solid Tumors

While CAR-T therapies have achieved impressive results against blood cancers, engineering immune cells like T cells and NK cells to effectively target solid tumors remains an important opportunity area. The immunosuppressive tumor microenvironment poses unique challenges for cell therapy approaches as opposed to liquid tumors. Advancing technologies focused on increasing T cell persistence, overcoming inhibitory checkpoints, and improving trafficking capability could play a key role. Emerging strategies under investigation include targeting novel solid tumor-associated antigens, combining CAR-T cells with immune checkpoint inhibitors or oncolytic viruses, selectively depleting suppressive immune subsets in tumors, and engineered TIL (tumor infiltrating lymphocyte) therapies. Progress in these areas could unlock the potential of engineered immune cells to treat many epithelial cancers with high unmet need like those of the pancreas, lung, and breast. Companies developing these next-generation CAR technologies and combination regimens represent promising investment opportunities.

Increasing Focus on Allogeneic "Off-the-Shelf" Cell Therapy Models

A major trend impacting the immune cell engineering industry is the rising interest in developing allogeneic "off-the-shelf" cell therapy treatment models. These therapies involve screening and banking engineered donor immune cells that could treat multiple recipients without the need for personalized manufacturing. This represents an attractive alternative to autologous cell therapies requiring individual patient harvest, engineering, and reinfusion. Key benefits include significantly reduced production costs per patient and faster accessibility without lengthy preparation times. Several companies are engineering T cells, NK cells, and dendritic cells to be universal donors by gene editing out endogenous TCRs or introducing safety switches. Clinical evaluation of these "universal" cell types for both hematologic and solid tumors is ongoing. As technology advances to reliably produce allogeneic cell therapies, this model is anticipated to eventually displace autologous approaches and enable adoption of cell therapies into broader community oncology settings.

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𝐅𝐀𝐐'𝐬

Q.1 What are the main factors influencing the Immune Cell Engineering market?
Q.2 Which companies are the major sources in this industry?
Q.3 What are the market's opportunities, risks, and general structure?
Q.4 Which of the top Immune Cell Engineering Market companies compare in terms of sales, revenue, and prices?
Q.5 Which businesses serve as the Immune Cell Engineering market's distributors, traders, and dealers?
Q.6 How are market types and applications and deals, revenue, and value explored?
Q.7 What does a business area's assessment of agreements, income, and value implicate?

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𝐀𝐛𝐨𝐮𝐭 𝐔𝐬:

Coherent Market Insights is a global market intelligence and consulting organization focused on assisting our plethora of clients achieve transformational growth by helping them make critical business decisions. We are headquartered in India, having sales office at global financial capital in the U.S. and sales consultants in United Kingdom and Japan. Our client base includes players from across various business verticals in over 57 countries worldwide. We create value for clients through our highly reliable and accurate reports. We are also committed in playing a leading role in offering insights in various sectors post-COVID-19 and continue to deliver measurable, sustainable results for our clients.

Contact Us:

Mr. Shah
Coherent Market Insights Pvt. Ltd,
📞Phone: U.S.: +1-206-701-6702
📞U.K.: +44-020-8133-4027
📞JAPAN: +81-50-5539-1737
📞INDIA: +91-848-285-0837
✉ Email: sales@coherentmarketinsights.com

𝐀𝐛𝐨𝐮𝐭 𝐔𝐬:

Coherent Market Insights is a global market intelligence and consulting organization focused on assisting our plethora of clients achieve transformational growth by helping them make critical business decisions. We are headquartered in India, having sales office at global financial capital in the U.S. and sales consultants in United Kingdom and Japan. Our client base includes players from across various business verticals in over 57 countries worldwide. We create value for clients through our highly reliable and accurate reports. We are also committed in playing a leading role in offering insights in various sectors post-COVID-19 and continue to deliver measurable, sustainable results for our clients.

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