Myelofibrosis Market to Expand at a Significant Growth Rate During the Forecast Period (2023-32) - Estimates DelveInsight | Incyte, Geron, Karyopharm, Celgene, Pharma Essentia, Novartis, SecuraBio, Pharmaxis, Novartis, AstraZeneca, Cellenkos, Menarini

As per DelveInsight, the Myelofibrosis Market is anticipated to evolve immensely in the coming years owing to the rise in the number of cases of Myelofibrosis and the launch of new therapies in the market.

DelveInsight's "Myelofibrosis Market Insights, Epidemiology, and Market Forecast 2032" report delivers an in-depth understanding of the disease, historical and forecasted epidemiology, as well as the Myelofibrosis Market Size and Share in the seven major markets (7MM) (i.e., the United States, EU4 (Germany, Spain, Italy, France), the United Kingdom and Japan).

The market report covers emerging drugs, treatment practices, market share of individual Myelofibrosis therapies, and current & forecasted market size from 2019 to 2032. It also evaluates the current Myelofibrosis treatment practice/algorithm, market drivers & barriers, and unmet medical needs to curate the best of opportunities and assess the underlying potential of the market.

Myelofibrosis: An Overview
Myelofibrosis (MF) is a disorder in which normal bone marrow tissue is gradually replaced with a fibrous scar-like material. It is classified as a type of chronic leukemia and belongs to a group of blood disorders called myeloproliferative diseases. Over time, this leads to progressive bone marrow failure. Under normal conditions, the bone marrow provides a fine network of fibers on which the stem cells can divide and grow. Specialized cells in the bone marrow known as fibroblasts make these fibers. Myelofibrosis can be of two types: primary myelofibrosis and secondary myelofibrosis.

Primary myelofibrosis (also called Chronic Idiopathic Myelofibrosis, agnogenic myeloid metaplasia) develops on its own, due to certain genetic mutations. It occurs most often between ages 50 and 70 years, mostly in men. Secondary myelofibrosis occurs as a result of other disorders, particularly other blood disorders such as chronic myeloid leukemia, polycythemia vera, thrombocythemia, multiple myeloma, and lymphoma.

Initially, most people with primary myelofibrosis have no signs or symptoms. Eventually, fibrosis can lead to a reduction in the number of red blood cells, white blood cells, and platelets. A shortage of red blood cells (anemia) often causes extreme tiredness (fatigue) or shortness of breath. A loss of white blood cells can lead to an increased number of infections, and a reduction of platelets can cause easy bleeding or bruising.

Myelofibrosis Market Key Facts
• The therapeutic market of Myelofibrosis in the seven major markets is expected to increase during the study period (2019-2032) with a CAGR of 7.3%.
• According to the estimates, the highest market size of Myelofibrosis is found in the United States, followed by Japan.
• The total prevalent population of myelofibrosis in the 7MM comprised 39,700+ cases in 2021.
• In the United States, the total number of prevalent cases of Myelofibrosis was 19,815 cases in the year 2021.
• Among the EU-5 countries, Germany accounted for the highest number of myelofibrosis diagnosed prevalent cases, followed by the UK, whereas Spain accounted for the lowest number of cases in 2021.
• The total number of diagnosed prevalent cases of myelofibrosis in Japan is 5,300+ in 2021.

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Myelofibrosis Market
The market outlook section of the report helps to build a detailed comprehension of the historical, current, and forecasted market size by analyzing the impact of current and emerging Myelofibrosis therapies in the market. It also provides a detailed assessment of the Myelofibrosis market drivers & barriers, unmet needs, and emerging technologies.

The report gives complete details of the market trend for each marketed Myelofibrosis drug and late-stage pipeline therapies by evaluating their impact based on the annual cost of therapy, inclusion and exclusion criteria, mechanism of action (MOA), competition with other therapies, brand value, their impact on the market and view of the key opinion leaders.

Myelofibrosis Epidemiology
The epidemiology section covers detailed insights into the historical, and current Myelofibrosis patient pool and forecasted epidemiology trends for every seven major countries (7MM) from 2019 to 2032.

The Report Covers the Myelofibrosis Epidemiology Segmented as -
• Total Prevalent Cases of Myelofibrosis in the 7MM (2019-2032)
• Total Diagnosed Prevalent cases of Myelofibrosis in the 7MM (2019-2032)
• Type-specific Prevalent Cases of Myelofibrosis in the 7MM (2019-2032)
• Transplant Eligible/Ineligible Cases of Myelofibrosis in the 7MM (2019-2032)
• Myelofibrosis Cases Based on Molecular Alterations in the 7MM (2019-2032)
• Age-specific Prevalent Cases of Myelofibrosis in the 7MM (2019-2032)
• Myelofibrosis cases Based on Risk Stratification in the 7MM (2019-2032)

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Myelofibrosis Drugs Uptake and Pipeline Development Activities
The drugs' uptake section focuses on the rate of uptake of the potential drugs recently launched in the Myelofibrosis market or expected to be launched during the study period. The analysis covers the market share by Myelofibrosis drugs, patient uptake by therapies, and sales of each drug.

The report's drugs uptake section helps in understanding the drugs with the most rapid uptake and the reasons behind the maximal use of new drugs. It allows the comparison of the drugs based on market share and size, which again will be helpful in investigating factors important in understanding the market dynamics and in making financial and regulatory decisions.

The report also covers the Myelofibrosis Pipeline Development Activities and provides valuable insights about different therapeutic candidates in Phase II and Phase III stages and the key companies in the market involved in developing targeted therapeutics. It also analyzes recent developments such as collaborations, acquisitions, mergers, licensing patent details, and other information for emerging therapies.

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Myelofibrosis Therapeutics Assessment
The treatment goal for most patients with myelofibrosis is to relieve symptoms, reduce an enlarged spleen, improve blood cell counts (i.e., anemia), and reduce the risk of complications. No drug therapy can cure myelofibrosis. The only potential cure for myelofibrosis is allogeneic stem cell transplantation, but this procedure is risky for older patients and those with other health problems. As myelofibrosis primarily affects older adults, stem cell transplantation is not a treatment option for most myelofibrosis patients. For most people with myelofibrosis, treatment remains aimed at controlling disease symptoms and complications, enhancing the quality of life, and extending survival.

Several major pharma and biotech companies are actively engaged in the development of therapies for Myelofibrosis, a serious bone marrow disorder. Among these companies, Incyte Corporation takes a prominent position, with its Myelofibrosis drug candidates progressing to the most advanced stage of clinical development, specifically in Phase III trials.

Leading Companies in the Myelofibrosis Therapeutics Market Include
Notable players in the Myelofibrosis Therapeutics Market Include Incyte Corporation, Keros Therapeutics, Karyopharm Therapeutics, Celgene Corporation, PharmaEssentia, Novartis, SecuraBio, Pharmaxis, Novartis Oncology, AstraZeneca, Cellenkos, Jacobio Pharmaceuticals, Ohmoncology, Geron Corporation, AbbVie, Sierra Oncology, Galecto Biotech, Actuate Therapeutics, Kartos Therapeutics, Menarini Group, Telios Pharma, Novartis Pharmaceuticals, NS Pharma, Celgene/Bristol-Myers Squibb, MorphoSys, Imago BioSciences, and Roche.

Emerging and Marketed Myelofibrosis Therapies Covered in the Report Include
• Parsaclisib: Incyte Corporation
• KER-050: Keros Therapeutics
• Momelotinib: Sierra Oncology
• Navitoclax (ABT-263): AbbVie
• Parsaclisib (INCB050465): Incyte
• REBLOZYL (Luspatercept/ACE-536): Celgene/Bristol Myers Squibb
• Pelabresib: MorphoSys
And Many Others

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Table of Content (TOC)
1. Key Insights
2. Executive Summary
3. Myelofibrosis Competitive Intelligence Analysis
4. Myelofibrosis Market Overview at a Glance
5. Myelofibrosis Background and Overview
6. Myelofibrosis Patient Journey
7. Myelofibrosis Epidemiology and Patient Population
8. Myelofibrosis Treatment Algorithm, Current Treatment, and Medical Practices
9. Myelofibrosis Unmet Needs
10. Key Endpoints of Myelofibrosis Treatment
11. Myelofibrosis Marketed Products
12. Myelofibrosis Emerging Therapies
13. Myelofibrosis Seven Major Market Analysis
14. Attribute Analysis
15. Myelofibrosis Market Outlook (7 major markets)
16. Myelofibrosis Access and Reimbursement Overview
17. KOL Views on the Myelofibrosis Market.
18. Myelofibrosis Market Drivers
19. Myelofibrosis Market Barriers
20. Appendix
21. DelveInsight Capabilities
22. Disclaimer
*The table of contents is not exhaustive; the final content may vary.

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