Comprehensive Analysis of Pre-Eclampsia Pipeline Drugs (2023 Update): FDA Approvals, Clinical Trials, Therapeutic Approaches, Mechanisms of Action, and Route of Administration by DelveInsight

(Albany, USA) DelveInsight's 'Pre-Eclampsia Pipeline Insight 2023' report provides comprehensive global coverage of available, marketed, and pipeline Pre-Eclampsia therapies in various stages of clinical development, major pharmaceutical companies are working to advance the pipeline space and future growth potential of the Pre-Eclampsia pipeline domain.

For Pre-Eclampsia emerging drugs, the Pre-Eclampsia pipeline analysis report provides a 360° view of the therapeutics landscape by development point, product type, route of administration, molecule type, and MOA. The pipeline research covers business opportunities, challenges, future partnerships, strong competitors, and growth strategies.

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Key Takeaways from the Pre-Eclampsia Pipeline Report
• Different Pre-Eclampsia pipeline therapies are in various stages of development, and their anticipated acceptance in the Pre-Eclampsia market would significantly increase market revenue.
• Leading Pre-Eclampsia companies developing novel drug candidates to improve the Pre-Eclampsia treatment landscape include Kyowa Kirin Co., Ltd, Pharming Group, Amag Pharmaceuticals, MirZyme, Evergreen Therapeutics, Dilafor, and others.
• Promising Pre-Eclampsia pipeline therapies in various stages of development include KW3357, rhC1INH protein replacement therapy, siRNA therapy, C103, GMA312, Tafoxiparin, EG-101, and others.
• In Aug 2023, Comanche Biopharma Receives US FDA Fast Track Designation for CBP-4888 for the Treatment of sFlt-1 mediated pre-term preeclampsia

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Pre-Eclampsia Overview
Pre-Eclampsia is a pregnancy complication marked by high blood pressure and signs of organ damage, most commonly the liver and kidneys. Pre-Eclampsia is a pregnancy condition characterized by hypertension (high blood pressure) and proteinuria (the presence of protein in your urine). It usually appears during the third trimester. The condition affects between 5% and 8% of pregnancies and has serious health consequences for mothers and babies. There is no single cause, but genetic factors and blood vessel problems are two possibilities. Pre-Eclampsia, if left untreated, can cause serious - even fatal - complications for both mother and baby.

Pre-Eclampsia Pipeline Analysis: Drug Profile
• Tafoxiparin: Dilafor
Tafoxiparin, a proprietary heparan sulfate mimetic, has been shown in preclinical and clinical data to supplement and fulfill the role of heparan sulfate, which is required for optimal oxytocin effectiveness. Tafoxiparin's mechanism of action has been supported by preclinical experiments and clinical studies when used in conjunction with oxytocin in current clinical practice. Tafoxiparin can improve uterine contractions and may promote cervical softening, potentially lowering the incidence of protracted labor and its associated complications. The drug is currently in Phase III development for the treatment of preeclampsia.

• KW3357: Kyowa Kirin Co., Ltd.
KW-3357 is an antithrombin (AT) drug developed using recombinant DNA and sugar-chain control technology. It is a recombinant AT preparation with the same amino acid sequence and sugar chain structure as human natural AT. AT inhibits blood coagulation by forming a complex with the proteolytic enzyme's coagulation factor. Since July 2015, KW-3357 has been approved in Japan for treating thrombophilia due to congenital AT deficiency (CAD) and disseminated intravascular coagulation (DIC) and is marketed under the brand name ACOALAN. Kyowan Kirin Co., Ltd is currently developing KW3357 in collaboration with Japan Blood Products Organization for Preeclampsia.

Pre-Eclampsia Pipeline Therapies and Key Companies
• KW3357: Kyowa Kirin Co., Ltd.
• rhC1INH protein replacement therapy: Pharming Group
• Tafoxiparin: Dilafor
• EG-101: Evergreen Therapeutics
• Preeclampsia Research Project: MirZyme
• siRNA therapy: Comanche Biopharma
• C 103: Vicore Pharma
• GMA 312: Gmax Biopharm

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Pre-Eclampsia Pipeline Therapeutics Assessment
By Product Type
• Monotherapy
• Combination Therapy

By Stage
• Discovery
• Pre-Clinical
• Phase I
• Phase II
• Phase III
• Pre-registration

By Route of Administration
• Subcutaneous
• Intravenous
• Oral

By Molecule Type
• Replacement Therapy
• Physiological Saline
• Antihypertensive

Scope of the Pre-Eclampsia Pipeline Report
• Coverage: Global
• Key Pre-Eclampsia Companies: Kyowa Kirin Co., Ltd, Pharming Group (AMS: PHARM), Amag Pharmaceuticals, MirZyme, Evergreen Therapeutics, Dilafor, and others.
• Key Pre-Eclampsia Pipeline Therapies: KW3357, rhC1INH protein replacement therapy, siRNA therapy, C103, GMA312, Tafoxiparin, EG-101, and others.

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Table of Contents
1.Introduction
2.Pre-Eclampsia Executive Summary
3.Pre-Eclampsia Overview
4.Pre-Eclampsia Pipeline Therapeutics
5.Pre-Eclampsia Pipeline: Late Stage Products (Phase III)
6.Pre-Eclampsia Pipeline: Mid Stage Products (Phase II)
7.Pre-Eclampsia Pipeline: Early Stage Products (Phase I/II)
8.Pre-Eclampsia Pipeline: Preclinical Stage Products
9.Pre-Eclampsia Pipeline: Discovery Stage Products
10.Pre-Eclampsia Pipeline Therapeutic Assessment
11.Pre-Eclampsia Pipeline: Inactive Products
12.Collaborations Assessment- Licensing / Partnering / Funding
13.Unmet Needs
14.Market Drivers and Barriers
15.Appendix
16.About DelveInsight

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