Allogeneic Stem Cell Transplantation Market is Estimated to Witness High Growth Owing to Increasing Disease Burden of Cancer

Market Overview:

Allogeneic stem cell transplantation involves transplantation of hematopoietic stem cells from a healthy donor to a patient. It is a treatment option for various blood cancers and immune disorders. The stem cells used can come from bone marrow, peripheral blood, or umbilical cord blood.

Market Dynamics:

The allogeneic stem cell transplantation market is expected to witness significant growth over the forecast period owing to two main drivers-

Firstly, the increasing incidence of cancers globally is expected to drive the market growth. According to GLOBOCAN 2020, cancer burden has risen to 19.3 million new cases and 10 million cancer deaths in 2020. Several cancers including leukemia, lymphoma and multiple myeloma are treated using allogeneic stem cell transplantation.

Secondly, ongoing research to expand application scope and development of novel transplantation techniques is also fueling the market growth. Researchers are exploring the feasibility of using allogeneic transplantation in solid organ cancers and autoimmune disorders. Techniques like reduced-intensity conditioning improve eligibility criteria and reduce transplant-related toxicity risks.

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Increasing prevalence of cancer as a major market driver

Cancer is one of the leading causes of mortality worldwide. According to the World Health Organization (WHO), cancer was responsible for an estimated 9.6 million deaths in 2018. Some of the common types of cancer that have shown increasing incidence rates in recent years include breast cancer, lung cancer, colorectal cancer, prostate cancer, skin cancer, lymphoma, leukemia, kidney cancer, liver cancer, multiple myeloma and others. Allogeneic stem cell transplantation is an important treatment option for various types of blood cancers like leukemia. It is also used for treatment of other cancers like lymphomas. The increasing prevalence of cancer cases globally has resulted in rising demand for advanced treatment procedures like allogeneic stem cell transplantation. This has been a major factor fueling growth in the allogeneic stem cell transplantation market.

Advancements in stem cell transplantation procedures as another key market driver

Over the past few decades, there have been significant advancements in stem cell transplantation techniques and procedures. Researchers have developed novel protocols to improve engraftment and reduce risks of graft failure and graft-versus-host disease. Technological developments like use of peripheral blood as a stem cell source instead of bone marrow and use of reduced intensity conditioning regimens have enabled transplantation of elderly and medically unfit patients. Introduction of high-resolution HLA-typing techniques has further improved donor-recipient matching. Umbilical cord blood is now being increasingly used as an alternative stem cell source. Continuous improvements in post-transplant care have also enhanced survival outcomes. Such advancements have made allogeneic stem cell transplantation a more viable and preferred treatment option. This has positively impacted the growth dynamics of this market.

Stringent regulatory environment restraining market growth

Allogeneic stem cell transplantation being an advanced specialized procedure, it is strictly regulated by healthcare regulatory bodies across countries. Regulations pertaining to donor eligibility criteria, cell processing, storage and distribution significantly impact this market. Obtaining regulatory approvals for new stem cell sources, modified procedures and technologies is a complex and lengthy process. Manufacturers must meet stringent quality standards and current Good Tissue Practices (cGTP). This increases compliance costs. Product withdrawals or field actions due to regulatory non-compliances can disrupt market dynamics. The dynamic regulatory scenario with differing guidelines across regions poses challenges for companies seeking international operations. Stringent regulatory oversight has restrained market growth to a certain extent by delaying product approvals and introductions.

Increasing emphasis on development of off-the-shelf cellular therapies presents lucrative opportunities

Traditionally, allogeneic stem cell transplantation relied on human leukocyte antigen (HLA) matched siblings or unrelated donors. However, a suitable donor is not always readily available. This has generated significant interest in the development of universal or off-the-shelf allogenic stem cell graft products that do not require perfect donor matching. Such off-the-shelf "ready-to-use" graft products are perceived to have advantages over standard donor transplantation procedures in terms of timely availability, cost-effectiveness and standardization. Major players are engaged in research on various strategies like use of stem cells from cord blood or modified T-cells to come up with generalized graft products. Development of successful off-the-shelf therapies can potentially capture a larger patient pool and revolutionize the allogeneic stem cell transplantation market. It presents lucrative opportunities for existing as well as new market entrants in the coming years.

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The emergence of hybrid transplantation techniques as a key market trend

A notable trend gaining prominence in the allogeneic stem cell transplantation market is the emergence of hybrid stem cell transplantation techniques that employ a combination of stem cell sources. Researchers are exploring novel approaches that use both bone marrow and peripheral blood-derived stem cells or a combination of stem cells from bone marrow, peripheral blood and umbilical cord blood. Some studies indicate that combined stem cell transplants from multiple sources could offer benefits like accelerated engraftment, reduced transplantation related risks, and improved clinical outcomes compared to conventional transplants using a single stem cell source. Industry players are actively investing in developing effective hybrid transplantation protocols and products. This evolving area holds promise and transition to hybrid techniques may shape the future dynamics of this specialty market.

Moreover, it will also include the opportunities available in micro markets for stakeholders to invest, a detailed analysis of the competitive landscape, and product services of key players. Analysis of Allogeneic Stem Cell Transplantation companies, key tactics followed by Leading Key Players:

◘ Celgene Corporation
◘ Mesoblast Ltd.
◘ Pluristem Therapeutics Inc.
◘ MEDIPOST Co., Ltd.,
◘ Takeda Pharmaceutical Company Limited
◘ Astellas Pharma Inc.
◘ Cellular Biomedicine Group Inc.
◘ Biosolution Co., Ltd.,
◘ StemCell Technologies Inc.
◘ Caladrius Biosciences Inc.
◘ TiGenix N.V.
◘ ViaCord
◘ Vericel Corporation
◘ Regen Biopharma Inc.
◘ Gamida Cell Ltd.
◘ Histogenics Corporation
◘ BrainStorm Cell Therapeutics Inc.
◘ Lineage Cell Therapeutics Inc.

Note: Major Players are sorted in no particular order.

By Source

◘ Bone Marrow
◘ Peripheral Blood
◘ Umbilical Cord Blood
◘ Adipose Tissue
◘ Dental Pulp
◘ Others

By Application

◘ Cancer
◘ Autoimmune Diseases
◘ Blood Disorders
◘ Cardiac Disorders
◘ Neurological Disorders
◘ Diabetes
◘ Others

By End User

◘ Hospitals
◘ Research Institutes
◘ Specialty Clinics
◘ Others

By Cell Type

◘ Allogeneic MSCs
◘ Allogeneic HSCs
◘ Others

The Study Objectives are:

A comprehensive insight into key players operating in the Allogeneic Stem Cell Transplantation Market and their corresponding data.
It includes product portfolio, annual revenue, expenditure on research and development, geographical presence, key developments in recent years, and growth strategies.
Regional analysis, which includes insight into the dominant market and corresponding market share.
It also includes various socio-economic factors affecting the evolution of the market in the region.
The report offers a comprehensive insight into different individuals from value chains such as raw materials suppliers, distributors, and stockholders.
Table of Contents:

Market scenario 2023

Chapter 1: Introduction, Market Driving Force Product Objective of Study and Research Scope the Allogeneic Stem Cell Transplantation market
Chapter 2: Exclusive Summary - the basic information of the Allogeneic Stem Cell Transplantation Market.
Chapter 3: Displaying the Market Dynamics- Drivers, Trends, and Challenges & Opportunities of the Allogeneic Stem Cell Transplantation
Chapter 4: Presenting the Allogeneic Stem Cell Transplantation Market Factor Analysis, Supply/Value Chain, PESTEL analysis, Market Entry, and Patent/Trademark Analysis.
Chapter 5: Displaying the by Type, End User, and Region/Country 2023 - 2030
Chapter 6: Evaluating the leading manufacturers of the Allogeneic Stem Cell Transplantation market which consists of its Competitive Landscape, Peer Group Analysis, Market positioning & Company Profile
Chapter 7: To evaluate the market by segments, by countries, and by Manufacturers/Companies with revenue share and sales by key countries in these various regions (2023-2030)
Chapters 8 & 9: Displaying the Appendix, Methodology, and Data Source

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Key Questions Answered:

What is the market size and CAGR of the Allogeneic Stem Cell Transplantation Market during the forecast period?
How is the growing demand impacting the growth of Allogeneic Stem Cell Transplantation Market shares?
What is the growing demand of the Market during the forecast period?
Who are the leading vendors in the market and what are their market shares?
What is the impact of the COVID-19 pandemic on the APAC Allogeneic Stem Cell Transplantation Market?

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