Press release
Liver Failure Market is Expected to Show a Healthy Growth Rate During the Study Period (2019-2032)| Key Companies - Novartis Pharmaceuticals, Merck, Tobira Therapeutics, Pfizer
Liver Failure Market
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Liver Failure Overview
Acute liver failure is the development of sudden, severe hepatic dysfunction from an acute insult to the liver, associated with the onset of hepatic encephalopathy and coagulation abnormalities. American Association for the Study of Liver Diseases (AASLD) defines it as the evidence of coagulation abnormality, usually an international normalized ratio above 1.5, and any degree of mental alteration (encephalopathy) in a patient without preexisting liver disease and with an illness of less than 26 weeks duration.
The condition is categorized into three categories based on the interval between the development of jaundice and the onset of encephalopathy. The first is hyperacute liver failure in which the onset of encephalopathy is within seven days after the development of jaundice. Second, acute liver failure in which the onset of encephalopathy is within eight to 28 days after the development of jaundice, and the third, sub-acute liver failure in which the onset of encephalopathy is more than 5 weeks but less than 12 weeks after the development of jaundice.
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Key Highlight from Liver Failure Market Report
In the study by Stravitz and Lee (2019), data were collected between Jan 1, 1998 and March 31, 2019. PubMed and MEDLINE using the terms "acute liver failure" or "fulminant hepatic failure" were searched, to identify studies and publications not already familiar to the authors, with no restrictions on date or location of publication. The total number of patients enrolled was 2614; paracetamol accounted for 46% of cases, 12% of cases had indeterminate causes, and drug-induced liver injury accounted for 11% of cases.
As per the above study by Stravitz and Lee (2019), the most commonly observed cause of ALF in developed countries is paracetamol toxicity, which causes 45·7% of cases recorded in North America, and 65·4% of cases in the UK. 80% of patients with ALF caused by autoimmune hepatitis are women. In the US and Europe, the hepatitis B virus causes around 8% of all cases of ALF, considerably fewer than paracetamol, drug-induced liver injury, or autoimmune hepatitis, but this virus is still an important and readily diagnosed cause. The remaining causes of ALF comprise fewer than 15% of the total and include heat stroke, pregnancy-associated injury (eg, acute fatty liver of pregnancy and HELLP [hemolysis, elevated liver enzyme, and low platelet] syndrome), Budd-Chiari syndrome, non hepatotropic viral infections such as herpes simplex, and diffusely infiltrating malignancies.
Liver Failure Treatment Market
Treatments (both preventive and therapeutic) available are pressure therapy, silicone gel sheeting, intra-lesional triamcinolone acetonide, cryosurgery (freezing), radiation, laser therapy (pulsed dye laser), interferon (IFN), fluorouracil (5-FU) and surgical excision as well as a multitude of extracts and topical agents. Appropriate treatment of a Liver Failure scar is age-dependent: radiotherapy, anti-metabolites, and corticosteroids would not be recommended to be used in children, in order to avoid harmful side effects, like growth abnormalities.
In adults, corticosteroids combined with 5-FU and PDL in triple therapy, enhance results and diminish side effects
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The Report Covers the Liver Failure Epidemiology Segmented by
Liver Failure prevalent cases
Liver Failure Incident Cases
Liver Failure treatment cases
Liver Failure diagnosed cases
Liver Failure Dug Profile and Companies Covered
Merck Pharmaceuticals-Dimebon
Tobira Therapeutics-ACP-196
Novartis Pharmaceuticals-Icenticaftor
Pfizer-LY3502970
Acereta Pharma BV-BI 1015550
And many others.
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Table of Contents
Key Insights
Liver Failure Introduction
Executive Summary of Liver Failure
Disease Background and Overview
Liver Failure Epidemiology and patient population
Liver Failure Emerging Therapies
Liver Failure Market Outlook
Liver Failure Market Access and Reimbursement of Therapies
Liver Failure Market Drivers
Liver Failure Market Barriers
Appendix
Liver Failure Report Methodology
DelveInsight Capabilities
Disclaimer
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DelveInsight Business Research LLP
Adya Kaul
info@delveinsight.com
https://www.delveinsight.com
DelveInsight is a leading Business Consultant and Market Research firm focused exclusively on life sciences. It supports Pharma companies by providing comprehensive end-to-end solutions to improve their performance. It also offers Healthcare Consulting Services, which benefits in market analysis to accelerate business growth and overcome challenges with a practical approach.
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