Autosomal Dominant Polycystic Kidney Disease Pipeline, Clinical Trials Assessment, NDA Approvals 2023 (Updated) | Galapagos NV, Reata Pharmaceuticals, Kadmon Pharmaceuticals, Sanofi, Anakuria Therapeutics, and others

DelveInsight's, "Autosomal dominant polycystic kidney disease Pipeline Insight 2023" report provides comprehensive insights about 12+ companies and 12+ pipeline drugs in Autosomal dominant polycystic kidney disease pipeline landscape. It covers the Autosomal dominant polycystic kidney disease pipeline drug profiles, including Autosomal dominant polycystic kidney disease clinical trials and nonclinical stage products. It also covers the Autosomal dominant polycystic kidney disease therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

Key takeaways from the Autosomal Dominant Polycystic Kidney Disease Pipeline Report
• DelveInsight's Autosomal Dominant Polycystic Kidney Disease Pipeline report depicts a robust space with 12+ active players working to develop 12+ pipeline therapies for Autosomal Dominant Polycystic Kidney Disease treatment.
• The leading Autosomal Dominant Polycystic Kidney Disease Companies includes Galapagos NV, Reata Pharmaceuticals, Kadmon Pharmaceuticals, Sanofi, Anakuria Therapeutics, Regulus Therapeutics, AceLink Therapeutics, Healx, XORTX Therapeutics, Poxel, Alebund Pharmaceuticals, Chinook Therapeutics, and others.
• Promising Autosomal Dominant Polycystic Kidney Disease Pipeline Therapies includes GLPG2737, Bardoxolone methyl, Tesevatinib/KD019, RGLS8429, AT-20494, XRx-008, and others.
• The Autosomal Dominant Polycystic Kidney Disease companies and academics that are working to assess challenges and seek opportunities that could influence Autosomal dominant polycystic kidney disease R&D. The Autosomal Dominant Polycystic Kidney Disease pipeline therapies under development are focused on novel approaches to treat/improve the disease condition.

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Autosomal Dominant Polycystic Kidney Disease Overview
Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disorder characterized by the formation of cysts within the kidneys. Symptoms caused by cyst formation in the kidneys include high blood pressure (hypertension), pain on the sides of the body between the last rib and the hip (flank pain), blood in the urine (hematuria) and progressively poor function of the kidneys (kidney insufficiency).

Recent Developmental Activities in the Autosomal Dominant Polycystic Kidney Disease Treatment Landscape
• On January 2023, Otsuka Pharmaceutical Development & Commercialization Inc announced a study of phase 3 clinical trials for Tolvaptan. The primary objective of the study is to assess the long term safety of treatment with tolvaptan in children and adolescents with autosomal dominant polycystic kidney disease (ADPKD). The secondary objective is to assess the pharmacodynamics, pharmacokinetics, and efficacy of tolvaptan in the same participant population.
• On July 2023, Regulus Therapeutics Inc announced a study of phase 1 clinical trials for RGLS8429. In this randomized, double-blind, placebo-controlled Phase 1b study, multiple ascending doses of RGLS8429 or placebo will be administered via subcutaneous injection to subjects with ADPKD to evaluate the safety, tolerability, pharmacodynamics and pharmacokinetics of RGLS8429.

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Autosomal Dominant Polycystic Kidney Disease Emerging Drugs Profile

• GLPG2737: Galapagos NV
GLPG2737 is a Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) inhibitor which was observed to be well tolerated by patients in previous clinical trials. It is hypothesized that inhibition of the CFTR channel might reduce cyst growth and enlargement for patients with autosomal dominant polycystic kidney disease (ADPKD).

• Bardoxolone methyl: Reata Pharmaceuticals
Bardoxolone is an investigational, once-daily, orally administered activator of Nrf2, a transcription factor that induces molecular pathways that promote the resolution of inflammation by restoring mitochondrial function, reducing oxidative stress, and inhibiting pro-inflammatory signaling. The FDA and European Commission have granted Orphan Drug designation to bardoxolone for the treatment of Alport syndrome and autosomal dominant polycystic kidney disease ("ADPKD").

Autosomal Dominant Polycystic Kidney Disease Pipeline Therapeutics Assessment
There are approx. 12+ key companies which are developing the therapies for Autosomal dominant polycystic kidney disease. The companies which have their Autosomal dominant polycystic kidney disease drug candidates in the most advanced stage, i.e. phase III include, Reata Pharmaceuticals.

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Scope of the Autosomal Dominant Polycystic Kidney Disease Pipeline Report
• Coverage- Global
• Autosomal Dominant Polycystic Kidney Disease Companies- Galapagos NV, Reata Pharmaceuticals, Kadmon Pharmaceuticals, Sanofi, Anakuria Therapeutics, Regulus Therapeutics, AceLink Therapeutics, Healx, XORTX Therapeutics, Poxel, Alebund Pharmaceuticals, Chinook Therapeutics, and others.
• Autosomal Dominant Polycystic Kidney Disease Pipeline Therapies- GLPG2737, Bardoxolone methyl, Tesevatinib/KD019, RGLS8429, AT-20494, XRx-008, and others.
• Autosomal Dominant Polycystic Kidney Disease Pipeline Segmentation: Product Type, Molecule Type, Mechanism of Action, Route of Administration

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Table of Content
1. Introduction
2. Executive Summary
3. Autosomal dominant polycystic kidney disease: Overview
4. Pipeline Therapeutics
5. Therapeutic Assessment
6. Autosomal dominant polycystic kidney disease - DelveInsight's Analytical Perspective
7. Late Stage Products (Phase III)
8. Bardoxolone methyl: Reata Pharmaceuticals
9. Drug profiles in the detailed report…..
10. Mid Stage Products (Phase II)
11. GLPG2737: Galapagos NV
12. Drug profiles in the detailed report…..
13. Early Stage Products (Phase I)
14. AL 01211: AceLink Therapeutics
15. Drug profiles in the detailed report…..
16. Preclinical and Discovery Stage Products
17. AT 20494: Anakuria Therapeutics
18. Drug profiles in the detailed report…..
19. Inactive Products
20. Autosomal dominant polycystic kidney disease Key Companies
21. Autosomal dominant polycystic kidney disease Key Products
22. Autosomal dominant polycystic kidney disease- Unmet Needs
23. Autosomal dominant polycystic kidney disease- Market Drivers and Barriers
24. Autosomal dominant polycystic kidney disease- Future Perspectives and Conclusion
25. Autosomal dominant polycystic kidney disease Analyst Views
26. Autosomal dominant polycystic kidney disease Key Companies
27. Appendix

About Us

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