Rare Kidney Diseases Market | Size, Share and Scope Analysis to 2031

Global Rare Kidney Diseases Market By Target Indications (IgA Nephropathy, Membranous Nephropathy, Lupus Nephritis, C3 Glomerulopathy, Focal Segmental Glomerular Sclerosis, and Others), Type of Molecule (Small Molecules and Biologics (Hormone, Monoclonal Antibody, Recombinant Protein, and Others)), Route of Administration (Intravenous, Oral, Subcutaneous, and Others))- Market Outlook and Industry Analysis 2031"

According to company's newest research, the global rare kidney diseases market is predicted to exhibit a promising CAGR of 16% between 2022 and 2030.
Rare kidney diseases (RKD) encompass approximately 150 distinct conditions. In the United States (US) and Europe, the prevalence of rare kidney diseases is estimated to range between 60 and 80 per 100,000 cases/individuals.

Approximately one-third of adults with diabetes and one-fifth of adults with hypertension may have kidney disease. Kidney diseases kill more people than breast and prostate cancers combined (NVS 2021 report of 2018 data). Kidney disease patients are five to ten times more probable to die prematurely than to develop kidney failure with replacement therapy (KFRT). It's important to note that after the COVID-19 pandemic started, it became even harder to treat people with rare kidney diseases. This is mainly because most current treatments for these conditions require patients to go to the hospital or medical center often. As a result, the death rate for sick people during the pandemic went up by 30%. This rise in death rates has forced people in the pharmaceutical industry to do the research they need to find new drugs that can effectively treat rare kidney diseases.

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Multiple important factors are propelling the market expansion for rare kidney diseases. The collaborative interactions between clinicians, patients, industry representatives, regulatory agents, and government agencies contribute to the increase in the demand for complex illnesses due to diagnostic and therapeutic advances. In addition, the increased use of next-generation sequencing techniques is anticipated to improve diagnostic accuracy for rare renal diseases, contribute to the elucidation of molecular disease mechanisms, facilitate genetic counselling, and offer opportunities for carrier testing. Renal replacement therapy innovations and increased accessibility allow patients to live longer at the expense of their quality of life.

Therapeutic advances in rare kidney diseases have been hampered by unresolved genetic defects, a lack of biomarkers to track disease progression, heterogeneous clinical phenotypes, and obsolete diagnostic classifications that do not reflect underlying pathophysiological mechanisms. Slow drug approvals and detailed studies will also restrain market expansion.

As a result of its rapid clinical advancements and research into kidney disease treatments, North America will dominate and lead the global market for rare kidney diseases during the projected period.

The key market players are GlaxoSmithKline, Recordati Rare Diseases, Amicus Therapeutics, Calliditas Therapeutics, Alexion Pharmaceuticals (A subsidiary of AstraZeneca), Travere Therapeutics, Aurinia Pharmaceutical, Advicenne, Protalix Biotherapeutics, AstraZeneca, Chinook Therapeutics, Reata Pharmaceuticals, Roche, Novartis Pharmaceuticals, Merk & co., Apellis Pharmaceuticals, Omeros Corporation, Lonza, and Other Prominent Players.

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Key Developments in The Market:
• In Aug 2022, CSL Vifor and Travere Therapeutics announced that the European Medicines Agency (EMA) has accepted for review the Conditional Marketing Authorization (CMA) application for sparsentan for the treatment of a rare kidney disorder IgAN, and a leading cause of end-stage kidney disease (ESKD).
• In Dec 2021, The FDA approved the first drug to reduce urine protein levels in IgA nephropathy, a rare kidney disease. Tarpeyo (budesonide) delayed-release capsules have been granted accelerated approval by the FDA to minimise proteinuria (increased protein levels in the urine) in adults with primary immunoglobulin A (IgA) nephropathy who are at risk of rapid disease progression.
• In Sept 2021, Allarity Therapeutics and Lonza agreed to collaborate on developing and manufacturing dovitinib, Allarity's renal cell carcinoma candidate therapy. The agreement called for the start of dovitinib manufacturing in 2022 to meet Allarity's projected needs for bringing dovitinib to market after regulatory approvals.
• In June 2021, Novartis announced new Phase II interim data for iptacopan in the rare kidney disease C3 glomerulopathy (C3G). Iptacopan is being developed for a number of (CDRDs) complement-driven renal diseases, including C3Gand (IgAN) IgA nephropathy, the blood disorder paroxysmal nocturnal hemoglobinuria (PNH), with the goal of addressing a vital driver of these diseases.

Market Segmentation
Global Rare Kidney Diseases Market, by Target Indication, 2023-2031 (Value US$ Mn)
• IgA Nephropathy
• Lupus Nephritis
• Focal Segmental Glomerular Sclerosis
• Membranous Nephropathy
• C3 Glomerulopathy
• Cystinosis
• Dense Deposit Disease
• Distal Renal Tubular Acidosis
• Fabry Disease
• Refractory Gout
• Atypical Hemolytic Uremic Syndrome
• Others

Global Rare Kidney Diseases Market, by Type of Molecule, 2023-2031 (Value US$ Mn)
• Small Molecules
• Biologics
o Monoclonal Antibody
o Hormone
o Recombinant Protein
o Others

Global Rare Kidney Diseases Market, by Route of Administration, 2023-2031 (Value US$ Mn)
• Oral
• Intravenous
• Subcutaneous
• Others

Global Rare Kidney Diseases Market, by Region, 2023-2031 (Value US$ Mn)
• North America
• Europe
• Asia Pacific
• Latin America
• Middle East & Africa

North America Rare Kidney Diseases Market, by Country, 2023-2031 (Value US$ Mn)
• U.S.
• Canada

Europe Rare Kidney Diseases Market, by Country, 2023-2031 (Value US$ Mn)
• Germany
• France
• Italy
• Spain
• Russia
• Rest of Europe

Asia Pacific Rare Kidney Diseases Market, by Country, 2023-2031 (Value US$ Mn)
• India
• China
• Japan
• South Korea
• Australia & New Zealand

Latin America Rare Kidney Diseases Market, by Country, 2023-2031 (Value US$ Mn)
• Brazil
• Mexico
• Rest of Latin America

Middle East & Africa Rare Kidney Diseases Market, by Country, 2023-2031 (Value US$ Mn)
• GCC Countries
• South Africa
• Rest of Middle East & Africa

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