Congenital Hyperinsulinism Market to Witness Growth by 2032, Estimates DelveInsight | Zealand Pharma, Eli Lilly, Novo Nordisk, Novartis, Rezolute, Eiger BioPharma-ceuticals, Crinetics, AmideBio, Xeris Pharmaceuticals, Hanmi Pharmaceutical
The Congenital Hyperinsulinism market report provides current treatment practices, emerging drugs, the market share of the individual therapies, and the current and forecasted Congenital Hyperinsulinism market size from 2019 to 2032, segmented by seven major markets. The Report also covers current Congenital Hyperinsulinism treatment practice/algorithm, market drivers, market barriers, and unmet medical needs to curate the best opportunities and assesses the underlying potential of the Congenital Hyperinsulinism market.
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Some facts of the Congenital Hyperinsulinism Market Report are:
• According to DelveInsight, Congenital Hyperinsulinism market size is expected to grow at a decent CAGR by 2032.
• Leading Congenital Hyperinsulinism companies working in the market are Zealand Pharma, Eli Lilly, Novo Nordisk, Novartis, Rezolute, Eiger BioPharma-ceuticals, Crinetics, AmideBio, Xeris Pharmaceuticals, Hanmi Pharmaceutical, And many others.
• Key Congenital Hyperinsulinism Therapies expected to launch in the market are Dasiglucagon, RZ358, Avexitide, CRN04777, ABG-023, HM15136 , And many others.
• Delvelnsight has analyzed mutation-specific data of Congenital Hyperinsulinism, which suggests that mutations in the ABCC8 and KCNJ11 genes are the most common causes of Congenital Hyperinsulinism while mutations in several other genes (GLUD1, GCK, HADH, SLC16A1, HNF4A, and HNF1A) are also involved in the development of Congenital Hyperinsulinism . In the United States, in 2021, mutations in ABCC8 and KCNJ11 genes accounted for 4,917 cases, while other gene mutations accounted for 4,023 cases.
• In the EU5 countries, the diagnosed prevalence of Congenital Hyperinsulinism was maximum in the United Kingdom with 2,398 cases, followed by Germany with 2,066 cases in 2021. While, the least number of cases were in Spain, with 1,286 cases in 2021 respectively.
• In Japan, the diagnosed prevalence of Congenital Hyperinsulinism was 2,685 in 2021 growing at a CAGR of 1.0%.
Congenital Hyperinsulinism Overview
Congenital Hyperinsulinism is a rare genetic disorder characterized by excessive insulin production, leading to low blood sugar levels in infants and children. It is caused by mutations in genes responsible for regulating insulin secretion in the pancreas. Symptoms include seizures, lethargy, poor feeding, and developmental delays. Prompt diagnosis is crucial to prevent long-term complications such as brain damage. Treatment options include medications to manage blood sugar levels, frequent feedings, and in severe cases, surgical removal of part of the pancreas. Long-term monitoring is necessary to ensure proper growth and development. Supportive care and education are essential for families affected by this condition.
Learn more about Congenital Hyperinsulinism treatment algorithms in different geographies, and patient journeys. Contact to receive a sample @ https://www.delveinsight.com/sample-request/congenital-hyperinsulinism-market?utm_source=openpr&utm_medium=pressrelease&utm_campaign=apr
Congenital Hyperinsulinism Market
The Congenital Hyperinsulinism market outlook of the report helps to build a detailed comprehension of the historical, current, and forecasted Congenital Hyperinsulinism market trends by analyzing the impact of current Congenital Hyperinsulinism therapies on the market and unmet needs, and drivers, barriers, and demand for better technology.
This segment gives a thorough detail of the Congenital Hyperinsulinism market trend of each marketed drug and late-stage pipeline therapy by evaluating their impact based on the annual cost of therapy, inclusion and exclusion criteria, mechanism of action, compliance rate, growing need of the market, increasing patient pool, covered patient segment, expected launch year, competition with other therapies, brand value, their impact on the market and view of the key opinion leaders. The calculated Congenital Hyperinsulinism market data are presented with relevant tables and graphs to give a clear view of the market at first sight.
According to DelveInsight, the Congenital Hyperinsulinism market in 7MM is expected to witness a major change in the study period 2019-2032.
Congenital Hyperinsulinism Epidemiology
The Congenital Hyperinsulinism epidemiology section provides insights into the historical and current Congenital Hyperinsulinism patient pool and forecasted trends for seven individual major countries. It helps to recognize the causes of current and forecasted trends by exploring numerous studies and views of key opinion leaders. This part of the Congenital Hyperinsulinism market report also provides the diagnosed patient pool, trends, and assumptions.
Congenital Hyperinsulinism Epidemiology Segmentation
• Total Congenital Hyperinsulinism diagnosed prevalent cases
• Total Congenital Hyperinsulinism type specific diagnosed prevelant cases
• Total Congenital Hyperinsulinism mutation specific diagnosed prevalent cases
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Congenital Hyperinsulinism Drugs Uptake
This section focuses on the uptake rate of the potential Congenital Hyperinsulinism drugs recently launched in the Congenital Hyperinsulinism market or expected to be launched in 2019-2032. The analysis covers the Congenital Hyperinsulinism market uptake by drugs, patient uptake by therapies, and sales of each drug.
There is only one approved therapy for CHI in the market, namely, PROGLYCEM (diazoxide) - a non-diuretic benzothiadiazole derivative used for the management of symptomatic hypoglycemia. Proglycem capsules and suspension are manufactured by IVAX Pharmaceuticals and Teva Pharmaceuticals, respectively; the suspension was manufactured for Gate Pharmaceuticals, a division of Teva Pharmaceuticals. A number of children with CHI are partially or completely unresponsive to diazoxide. Second-line treatment with other agents such as octreotide/lanreotide are required in such children. Somatostatin receptor analogs (SSRIs), typically octreotide/lanreotide, which inhibit insulin release, are preferred as second-line treatment in diazoxide-unresponsive patients. The use of SSRAs is off-label as only diazoxide is approved for CHI.
Octreotide reduces insulin release by decreasing the insulin gene promoter activity, inhibiting voltage-dependent calcium channels and adenylyl cyclase activity. Long‐acting SSRAs are favored by families on account of the monthly injection regimen without recourse to daily injections as needed for octreotide therapy. One problem with using a long‐acting SSRA is the inability to reduce the dose, unlike with oral preparations such as diazoxide. Given that severity of CHI may naturally reduce over time, the use of fixed‐dose long‐acting SSRAs may be considered disproportionate.
Congenital Hyperinsulinism Pipeline Development Activities
The Congenital Hyperinsulinism report provides insights into different therapeutic candidates in Phase II, and Phase III stages. It also analyses Congenital Hyperinsulinism key players involved in developing targeted therapeutics.
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Congenital Hyperinsulinism Therapeutics Assessment
Major key companies are working proactively in the Congenital Hyperinsulinism Therapeutics market to develop novel therapies which will drive the Congenital Hyperinsulinism treatment markets in the upcoming years are
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Congenital Hyperinsulinism Report Key Insights
1. Congenital Hyperinsulinism Patient Population
2. Congenital Hyperinsulinism Market Size and Trends
3. Key Cross Competition in the Congenital Hyperinsulinism Market
4. Congenital Hyperinsulinism Market Dynamics (Key Drivers and Barriers)
5. Congenital Hyperinsulinism Market Opportunities
6. Congenital Hyperinsulinism Therapeutic Approaches
7. Congenital Hyperinsulinism Pipeline Analysis
8. Congenital Hyperinsulinism Current Treatment Practices/Algorithm
9. Impact of Emerging Therapies on the Congenital Hyperinsulinism Market
Table of Contents
1. Key Insights
2. Executive Summary
3. Congenital Hyperinsulinism Competitive Intelligence Analysis
4. Congenital Hyperinsulinism Market Overview at a Glance
5. Congenital Hyperinsulinism Disease Background and Overview
6. Congenital Hyperinsulinism Patient Journey
7. Congenital Hyperinsulinism Epidemiology and Patient Population
8. Congenital Hyperinsulinism Treatment Algorithm, Current Treatment, and Medical Practices
9. Congenital Hyperinsulinism Unmet Needs
10. Key Endpoints of Congenital Hyperinsulinism Treatment
11. Congenital Hyperinsulinism Marketed Products
12. Congenital Hyperinsulinism Emerging Therapies
13. Congenital Hyperinsulinism Seven Major Market Analysis
14. Attribute Analysis
15. Congenital Hyperinsulinism Market Outlook (7 major markets)
16. Congenital Hyperinsulinism Access and Reimbursement Overview
17. KOL Views on the Congenital Hyperinsulinism Market
18. Congenital Hyperinsulinism Market Drivers
19. Congenital Hyperinsulinism Market Barriers
21. DelveInsight Capabilities
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